Medical image segmentation remains challenging due to the vast diversity of anatomical structures, imaging modalities, and segmentation tasks. While deep learning has made significant advances, current approaches struggle to generalize as they require task-specific training or fine-tuning on unseen classes. We present Iris, a novel In-context Reference Image guided Segmentation framework that enables flexible adaptation to novel tasks through the use of reference examples without fine-tuning. At its core, Iris features a lightweight context task encoding module that distills task-specific information from reference context image-label pairs. This rich context embedding information is used to guide the segmentation of target objects. By decoupling task encoding from inference, Iris supports diverse strategies from one-shot inference and context example ensemble to object-level context example retrieval and in-context tuning. Through comprehensive evaluation across twelve datasets, we demonstrate that Iris performs strongly compared to task-specific models on in-distribution tasks. On seven held-out datasets, Iris shows superior generalization to out-of-distribution data and unseen classes. Further, Iris’s task encoding module can automatically discover anatomical relationships across datasets and modalities, offering insights into medical objects without explicit anatomical supervision.

We introduce Olympus, a new approach that transforms Multimodal Large Language Models (MLLMs) into a unified framework capable of handling a wide array of computer vision tasks. Utilizing a controller MLLM, Olympus delegates over 20 specialized tasks across images, videos, and 3D objects to dedicated modules. This instruction-based routing enables complex workflows through chained actions without the need for training heavy generative models. Olympus easily integrates with existing MLLMs, expanding their capabilities with comparable performance. Experimental results demonstrate that Olympus achieves an average routing accuracy of 94.75% across 20 tasks and precision of 91.82% in chained action scenarios, showcasing its effectiveness as a universal task router that can solve a diverse range of computer vision tasks.

Chemical reactions constitute a cornerstone of fundamental scientific inquiry, yet traditional methodologies and platforms are encumbered by excessive reagent and consumable demands. Emerging alternatives, such as microfluidic systems, while innovative, suffer from intricate fabrication processes and elevated costs associated with operator training. Other contemporary approaches face limitations including reagent compatibility constraints and prohibitively expensive instrumentation. To address these challenges, this study introduces a contactless chemical reaction platform leveraging an ultrasonic vortex field to achieve stable capture, microscale droplet transport, and sequential multi-droplet mixing without direct contact. This platform substantially reduces contamination risks, minimizes reagent and consumable usage, accommodates a broad spectrum of reagent types, and imposes minimal demands on operator expertise. Demonstrating robust performance in microdose reaction control, the system offers significant potential for advancing chemical research and its applications.

Microassembly plays an important role in fabricating complex structures with small basic components in industrial and biomedical fields. Inverted optical microscope could provide high-quality image feedback for microassembly with its continuously improving resolution. However, a compact stage capable of positioning and reorienting micro-objects while fitting within the limited space under an inverted optical microscope remains unavailable. This paper proposes a compact R-X-Y stage that can transport micro-objects over long distances in the X and Y directions, and reorient the objects by the 360-degree continuous rotation. Additionally, different from commonly putting the rotational stage on the X-Y stage, we mount the thin X-Y stage on a rotational stage. Thus, after aligning the centers of the visual field and rotational stage at the beginning, all the visiable micro-objects will not move out of the visual field during the rotation. We further integrate the R-X-Y stage and the dual-finger micromanipulator, and then use them to assemble 2-D patterns and complex 3-D micromachine. The obtained results and preliminary demonstration indicate that the proposed compact R-X-Y has great potential in assembling complex micromachines.

Abstract Large multimodal language models (MLLMs) such as GPT-4V and GPT-4o have achieved remarkable advancements in understanding and generating multimodal content, showcasing superior quality and capabilities across diverse tasks. However, their deployment faces significant challenges, including slow inference, high computational cost, and impracticality for on-device applications. In contrast, the emergence of small MLLMs, exemplified by the LLava-series models and Phi-3-Vision, offers promising alternatives with faster inference, reduced deployment costs, and the ability to handle domain-specific scenarios. Despite their growing presence, the capability boundaries between large and small MLLMs remain underexplored. In this work, we conduct a systematic and comprehensive evaluation to benchmark both small and large MLLMs, spanning general capabilities such as object recognition, temporal reasoning, and multimodal comprehension, as well as real-world applications in domains like industry and automotive. Our evaluation reveals that small MLLMs can achieve comparable performance to large models in specific scenarios but lag significantly in complex tasks requiring deeper reasoning or nuanced understanding. Furthermore, we identify common failure cases in both small and large MLLMs, highlighting domains where even state-of-the-art models struggle. We hope our findings will guide the research community in pushing the quality boundaries of MLLMs, advancing their usability and effectiveness across diverse applications.

We introduce pluralistic salient object detection (PSOD), a novel task aimed at generating multiple plausible salient segmentation results for a given input image. Unlike conventional SOD methods that produce a single segmentation mask for salient objects, this new setting recognizes the inherent complexity of real-world images, comprising multiple objects, and the ambiguity in defining salient objects due to different user intentions. To study this task, we present two new SOD datasets "DUTS-MM" and "DUTS-MQ", along with newly designed evaluation metrics. DUTS-MM builds upon the DUTS dataset but enriches the ground-truth mask annotations from three aspects which 1) improves the mask quality especially for boundary and fine-grained structures; 2) alleviates the annotation inconsistency issue; and 3) provides multiple ground-truth masks for images with saliency ambiguity. DUTS-MQ consists of approximately 100K image-mask pairs with human-annotated preference scores, enabling the learning of real human preferences in measuring mask quality. Building upon these two datasets, we propose a simple yet effective pluralistic SOD baseline based on a Mixture-of-Experts (MOE) design. Equipped with two prediction heads, it simultaneously predicts multiple masks using different query prompts and predicts human preference scores for each mask candidate. Extensive experiments and analyses underscore the significance of our proposed datasets and affirm the effectiveness of our PSOD framework.

The problem of class incremental learning (CIL) is considered. State-of-the-art approaches use a dynamic architecture based on network expansion (NE), in which a task expert is added per task. While effective from a computational standpoint, these methods lead to models that grow quickly with the number of tasks. A new NE method, dense network expansion (DNE), is proposed to achieve a better trade-off between accuracy and model complexity. This is accomplished by the introduction of dense connections between the intermediate layers of the task expert networks, that enable the transfer of knowledge from old to new tasks via feature sharing and reusing. This sharing is implemented with a cross-task attention mechanism, based on a new task attention block (TAB), that fuses information across tasks. Unlike traditional attention mechanisms, TAB operates at the level of the feature mixing and is decoupled with spatial attentions. This is shown more effective than a joint spatial-and-task attention for CIL. The proposed DNE approach can strictly maintain the feature space of old classes while growing the network and feature scale at a much slower rate than previous methods. In result, it outperforms the previous SOTA methods by a margin of 4% in terms of accuracy, with similar or even smaller model scale.

Recent works of multi-source domain adaptation focus on learning a domain-agnostic model, of which the parameters are static. However, such a static model is difficult to handle conflicts across multiple domains, and suffers from a performance degradation in both source domains and target domain. In this paper, we present dynamic transfer to address domain conflicts, where the model parameters are adapted to samples. The key insight is that adapting model across domains is achieved via adapting model across samples. Thus, it breaks down source domain barriers and turns multi-source domains into a single-source domain. This also simplifies the alignment between source and target domains, as it only requires the target domain to be aligned with any part of the union of source domains. Furthermore, we find dynamic transfer can be simply modeled by aggregating residual matrices and a static convolution matrix. Experimental results show that, without using domain labels, our dynamic transfer outperforms the state-of-the-art method by more than 3% on the large multi-source domain adaptation datasets – DomainNet. Source code is at https://github.com/liyunsheng13/DRT.

This paper aims at addressing the problem of substantial performance degradation at extremely low computational cost (e.g. 5M FLOPs on ImageNet classification). We found that two factors, sparse connectivity and dynamic activation function, are effective to improve the accuracy. The former avoids the significant reduction of network width, while the latter mitigates the detriment of reduction in network depth. Technically, we propose micro-factorized convolution, which factorizes a convolution matrix into low rank matrices, to integrate sparse connectivity into convolution. We also present a new dynamic activation function, named Dynamic Shift Max, to improve the non-linearity via maxing out multiple dynamic fusions between an input feature map and its circular channel shift. Building upon these two new operators, we arrive at a family of networks, named MicroNet, that achieves significant performance gains over the state of the art in the low FLOP regime. For instance, under the constraint of 12M FLOPs, MicroNet achieves 59.4% top-1 accuracy on ImageNet classification, outperforming MobileNetV3 by 9.6%. Source code is at https://github.com/liyunsheng13/micronet.

A new paradigm is proposed for autonomous driving. The new paradigm lies between the end-to-end and pipelined approaches, and is inspired by how humans solve the problem. While it relies on scene understanding, the latter only considers objects that could originate hazard. These are denoted as action inducing, since changes in their state should trigger vehicle actions. They also define a set of explanations for these actions, which should be produced jointly with the latter. An extension of the BDD100K dataset, annotated for a set of 4 actions and 21 explanations, is proposed. A new multi-task formulation of the problem, which optimizes the accuracy of both action commands and explanations, is then introduced. A CNN architecture is finally proposed to solve this problem, by combining reasoning about action inducing objects and global scene context. Experimental results show that the requirement of explanations improves the recognition of action-inducing objects, which in turn leads to better action predictions.

The transfer of a neural network (CNN) trained to recognize objects to the task of scene classification is considered. A Bag-of-Semantics (BoS) representation is first induced, by feeding scene image patches to the object CNN, and representing the scene image by the ensuing bag of posterior class probability vectors (semantic posteriors). The encoding of the BoS with a Fisher vector (FV) is then studied. A link is established between the FV of any probabilistic model and the Q-function of the expectation-maximization (EM) algorithm used to estimate its parameters by maximum likelihood. This enables 1) immediate derivation of FVs for any model for which an EM algorithm exists, and 2) leveraging efficient implementations from the EM literature for the computation of FVs. It is then shown that standard FVs, such as those derived from Gaussian or even Dirichlet mixtures, are unsuccessful for the transfer of semantic posteriors, due to the highly non-linear nature of the probability simplex. The analysis of these FVs shows that significant benefits can ensue by 1) designing FVs in the natural parameter space of the multinomial distribution, and 2) adopting sophisticated probabilistic models of semantic feature covariance. The combination of these two insights leads to the encoding of the BoS in the natural parameter space of the multinomial, using a vector of Fisher scores derived from a mixture of factor analyzers (MFA). A network implementation of the MFA Fisher Score (MFA-FS), denoted as the MFAFSNet, is finally proposed to enable end-to-end training. Experiments with various object CNNs and datasets show that the approach has state-of-the-art transfer performance. Somewhat surprisingly, the scene classification results are superior to those of a CNN explicitly trained for scene classification, using a large scene dataset (Places). This suggests that holistic analysis is insufficient for scene classification. The modeling of local object semantics appears to be at least equally important. The two approaches are also shown to be strongly complementary, leading to very large scene classification gains when combined, and outperforming all previous scene classification approaches by a sizable margin.

The problem of multi-domain learning of deep networks is considered. An adaptive layer is induced per target domain and a novel procedure, denoted covariance normalization (CovNorm), proposed to reduce its parameters. CovNorm is a data driven method of fairly simple implementation, requiring two principal component analyzes (PCA) and fine-tuning of a mini-adaptation layer. Nevertheless, it is shown, both theoretically and experimentally, to have several advantages over previous approaches, such as batch normalization or geometric matrix approximations. Furthermore, CovNorm can be deployed both when target datasets are available sequentially or simultaneously. Experiments show that, in both cases, it has performance comparable to a fully fine-tuned network, using as few as 0.13% of the corresponding parameters per target domain.

Domain adaptation for semantic image segmentation is very necessary since manually labeling large datasets with pixel-level labels is expensive and time consuming. Existing domain adaptation techniques either work on limited datasets, or yield not so good performance compared with supervised learning. In this paper, we propose a novel bidirectional learning framework for domain adaptation of segmentation. Using the bidirectional learning, the image translation model and the segmentation adaptation model can be learned alternatively and promote to each other.Furthermore, we propose a self-supervised learning algorithm to learn a better segmentation adaptation model and in return improve the image translation model. Experiments show that our method superior to the state-of-the-art methods in domain adaptation of segmentation with a big margin. The source code is available at https://github.com/liyunsheng13/BDL.

The problem of transferring a deep convolutional network trained for object recognition to the task of scene image classification is considered. An embedded implementation of the recently proposed mixture of factor analyzers Fisher vector (MFA-FV) is proposed. This enables the design of a network architecture, the MFAFVNet, that can be trained in an end to end manner. The new architecture involves the design of a MFA-FV layer that implements a statistically correct version of the MFA-FV, through a combination of network computations and regularization. When compared to previous neural implementations of Fisher vectors, the MFAFVNet relies on a more powerful statistical model and a more accurate implementation. When compared to previous non-embedded models, the MFAFVNet relies on a state of the art model, which is now embedded into a CNN. This enables end to end training. Experiments show that the MFAFVNet has state of the art performance on scene classification.