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Yuan Jiang 0004

dblp:02/393-4 · DBLP profile ↗
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1ranked-venue papers
0as first author
0since 2021 · last 2018
0000-0001-9927-1289ORCID · verified

Domains — the database's venue-derived domains; a paper can count in several

Applied, interdisciplinary, general and emerging computing · 1

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
1 paper
Bioinformatics and computational biology · 100%

Topics — the 3 heaviest of 3, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Bioinformatics and computational biology › metagenomics › metagenomic binning
contig binning
0.312018
BMC3C: binning metagenomic contigs using codon usage, sequence composition and read coverage · Bioinform. 2018
Bioinformatics and computational biology
ensemble clustering
0.312018
BMC3C: binning metagenomic contigs using codon usage, sequence composition and read coverage · Bioinform. 2018
Bioinformatics and computational biology
metagenomics
0.312018
BMC3C: binning metagenomic contigs using codon usage, sequence composition and read coverage · Bioinform. 2018

Methods — techniques the papers use, named apart from their topics

k-means clustering · 0.3graph partitioning · 0.3codon usage features · 0.3
YearPublicationVenuePosition
2018 BMC3C: binning metagenomic contigs using codon usage, sequence composition and read coverage
abstract
Motivation: Metagenomics investigates the DNA sequences directly recovered from environmental samples. It often starts with reads assembly, which leads to contigs rather than more complete genomes. Therefore, contig binning methods are subsequently used to bin contigs into genome bins. While some clustering-based binning methods have been developed, they generally suffer from problems related to stability and robustness. Results: We introduce BMC3C, an ensemble clustering-based method, to accurately and robustly bin contigs by making use of DNA sequence Composition, Coverage across multiple samples and Codon usage. BMC3C begins by searching the proper number of clusters and repeatedly applying the k-means clustering with different initializations to cluster contigs. Next, a weight graph with each node representing a contig is derived from these clusters. If two contigs are frequently grouped into the same cluster, the weight between them is high, and otherwise low. BMC3C finally employs a graph partitioning technique to partition the weight graph into subgraphs, each corresponding to a genome bin. We conduct experiments on both simulated and real-world datasets to evaluate BMC3C, and compare it with the state-of-the-art binning tools. We show that BMC3C has an improved performance compared to these tools. To our knowledge, this is the first time that the codon usage features and ensemble clustering are used in metagenomic contig binning. Availability and implementation: The codes of BMC3C are available at http://mlda.swu.edu.cn/codes.php?name=BMC3C. Supplementary information: Supplementary data are available at Bioinformatics online.
Guoxian Yu, Yuan Jiang 0004, Jun Wang 0035, Hao Zhang 0213, Haiwei Luo
Bioinform.2