We describe ISIS, a high-performance-computing-based application to support computational epidemiology of infectious diseases. ISIS has been developed over the last seven years in close coordination with public health and policy experts. It has been used in a number of important federal planning and response exercises. ISIS grew out of years of experience in developing and using HPC-oriented models of complex socially coupled systems. This identified the guiding principle that complex models will be used by domain experts only if they can do realistic analysis without becoming computing experts.

We describe a first principles based integrated modeling environment to study urban socio-communication networks which represent not just the physical cellular communication network, but also urban populations carrying digital devices interacting with the cellular network. The modeling environment is designed specifically to understand spectrum demand and dynamic cellular network traffic. One of its key features is its ability to support individual-based models at highly resolved spatial and temporal scales. We have instantiated the modeling environment by developing detailed models of population mobility, device ownership, calling patterns and call network. By composing these models using an appropriate in-built workflow, we obtain an integrated model that represents a dynamic socio-communication network for an entire urban region. In contrast with earlier papers that typically use proprietary data, these models use open source and commercial data sets. The dynamic model represents for a normative day, every individual in an entire region, with detailed demographics, a minute-by-minute schedule of each person's activities, the locations where these activities take place, and calling behavior of every individual. As an illustration of the applicability of the modeling environment, we have developed such a dynamic model for Portland, Oregon comprising of approximately 1.6 million individuals. We highlight the unique features of the models and the modeling environment by describing three realistic case studies.