In today's fast-changing industrial landscape, organizations need resilience at both individual and organizational levels to stay competitive. The XPERTISE 5.0 research agenda proposes a deep-tech approach to enhancing workforce adaptability through artificial intelligence (AI), extended reality (XR), brain-computer interfaces (BCI), and adaptive learning systems. It examines how digital learning environments can foster resilience by offering personalized and tech-driven trainings. The research aims to develop a modular learning framework for organizations to customize training programs based on their needs, technology, and workforce capabilities. Using AI-driven personalization, real-time physiological feedback, and immersive simulations, this approach enhances knowledge retention, decision-making, and problem-solving skills. It also emphasizes human-centric digital transformation to help employees navigate technological disruptions. XPERTISE 5.0 supports the Industry 5.0 paradigm, highlighting resilience, sustainability, and human-technology collaboration. This research lays the foundation for scalable and adaptive training models across industries, promoting a future-ready workforce that embraces technological change and enhances organizational agility and innovation.