With the continuous application of single-cell data, effectively correcting batch effects and accurately identifying cell types has emerged as a critical challenge in biomedical research. However, existing methods often struggle to disentangle technical effects from genuine biological variation, limiting their performance on heterogeneous datasets. Here, we introduce single-cell Batch Correction Network (scBCN), an integration framework that combines robust inter-batch similar cluster identification with a deep residual neural network to correct batch effects while preserving biological variability. To evaluate the performance of scBCN, we conduct benchmarking experiments on various simulated and real datasets, demonstrating its superiority in both batch correction and biological variation conservation. Furthermore, scBCN shows its applicability in cross-species and cross-omics data integration, underscoring its potential for uncovering and characterizing cell type-specific gene expression patterns.

This study presents anchor-regularized generative adversarial network (GAN) priors to delicately explore the inherent knowledge of a pretrained generative model. Previous research leveraged the latent space of a pretrained GAN model to provide a variety of image-editing operations. However, the semantically meaningful regions within latent space are distinctly bounded; therefore, the manipulation of the latent code can easily land out of the domain. To address this problem, we introduce an anchoring mechanism that enables novel and robust image editing. The key insights driving the method are that latent space is structurally organized, and that natural coherence allows semantically correlated latent code to be located in the areas surrounding a meaningful anchor. By using different input anchors, the proposed method forms the basis for a variety of robust and flexible editing operations, including misaligned domain translation, interactive editing, and few-shot interpretable direction exploration. Extensive experiments demonstrated the superior performance of the proposed method compared with state-of-the-art editing methods.

This paper aims to resolve the challenging problem of wide-angle novel view synthesis from a single image, a.k.a. wide-angle 3D photography. Existing approaches rely on local context and treat them equally to inpaint occluded RGB and depth regions, which fail to deal with large-region occlusion (i.e., observing from an extreme angle) and foreground layers might blend into background inpainting. To address the above issues, we propose Diffuse3D which employs a pre-trained diffusion model for global synthesis, while amending the model to activate depth-aware inference. Our key insight is to alter the convolution mechanism in the denoising process. We inject depth information into the denoising convolution operation with bilateral kernels, i.e., a depth kernel and a spatial kernel, to consider layered correlations among pixels. In this way, foreground regions are overlooked in background inpainting and only pixels close in depth are leveraged. On the other hand, we propose a global-local balancing approach to maximize both contextual understandings. Extensive experiments demonstrate that our approach outperforms state-of-the-art methods in novel view synthesis, especially in wide-angle scenarios. More importantly, our method does not require any training and is a plug-and-play module that can be integrated with any diffusion model. Our code can be found at https://github.com/yutaojiang1/Diffuse3D.

This paper presents a Generative prior ReciprocAted Invertible rescaling Network (GRAIN) for generating faithful high-resolution (HR) images from low-resolution (LR) invertible images with an extreme upscaling factor (64×). Previous researches have leveraged the prior knowledge of a pretrained GAN model to generate high-quality upscaling results. However, they fail to produce pixel-accurate results due to the highly ambiguous extreme mapping process. We remedy this problem by introducing a reciprocated invertible image rescaling process, in which high-resolution information can be delicately embedded into an invertible low-resolution image and generative prior for a faithful HR reconstruction. In particular, the invertible LR features not only carry significant HR semantics, but also are trained to predict scale-specific latent codes, yielding a preferable utilization of generative features. On the other hand, the enhanced generative prior is re-injected to the rescaling process, compensating the lost details of the invertible rescaling. Our reciprocal mechanism perfectly integrates the advantages of invertible encoding and generative prior, leading to the first feasible extreme rescaling solution. Extensive experiments demonstrate superior performance against state-of-the-art upscaling methods. Code is available at https://github.com/cszzx/GRAIN.

The state-of-the-art photo upsampling method, PULSE, demonstrates that a sharp, high-resolution (HR) version of a given low-resolution (LR) input can be obtained by exploring the latent space of generative models. However, mapping an extreme LR input (162) directly to an HR image (10242) is too ambiguous to preserve faithful local facial semantics. In this paper, we propose an enhanced upsampling approach, Pro-PULSE, that addresses the issues of semantic inconsistency and optimization complexity. Our idea is to learn an encoder that progressively constructs the HR latent codes in the extended$\mathcal {W}+$latent space of StyleGAN. This design divides the complex$64\times $upsampling problem into several steps, and therefore small-scale facial semantics can be inherited from one end to the other. In particular, we train two encoders, the base encoder maps latent vectors in$\mathcal {W}$space and serves as a foundation of the HR latent vector, while the second scale-specific encoder performed in$\mathcal {W}+$space gradually replaces the previous vector produced by the base encoder at each scale. This process produces intermediate side-outputs, which injects deep supervision into the training of encoder. Extensive experiments demonstrate superiorities over the latest latent space exploration methods, in terms of efficiency, quantitative quality metrics, and qualitative visual results.