Label noise in training data can significantly degrade a model’s generalization performance for supervised learning tasks. Here we focus on the problem that noisy labels are primarily caused by mislabeled confusing samples, which tend to be concentrated near decision boundaries rather than uniformly distributed, and whose features should be equivocal. To address the problem, we propose an ensemble learning method to correct noisy labels by exploiting the local structures of feature manifolds. Different from typical ensemble strategies that increase the prediction diversity among sub-models via certain loss terms, our method trains sub-models on disjoint subsets, each being a union of randomly selected seed samples’ nearest-neighbors of the same class on the data manifold. As a result, only a limited number of sub-models will be affected by locally-concentrated noisy labels, and each sub-model can learn a coarse representation of the data manifold along with a corresponding graph. The constructed graphs are used to suggest a set of label correction candidates, and accordingly, our method determines label correction results by majority decisions. Our experiments on real-world noisy label datasets demonstrate the superiority of the proposed method over existing state-of-the-arts.

MOTIVATION: Ovarian cancer is the fifth leading cause of cancer deaths in women in the western world for 2013. In ovarian cancer, benign tumors turn malignant, but the point of transition is difficult to predict and diagnose. The 5-year survival rate of all types of ovarian cancer is 44%, but this can be improved to 92% if the cancer is found and treated before it spreads beyond the ovary. However, only 15% of all ovarian cancers are found at this early stage. Therefore, the ability to automatically identify and diagnose ovarian cancer precisely and efficiently as the tissue changes from benign to invasive is important for clinical treatment and for increasing the cure rate. This study proposes a new ovarian carcinoma classification model using two algorithms: a novel discretization of food sources for an artificial bee colony (DfABC), and a support vector machine (SVM). For the first time in the literature, oncogene detection using this method is also investigated. RESULTS: A novel bio-inspired computing model and hybrid algorithms combining DfABC and SVM was applied to ovarian carcinoma and oncogene classification. This study used the human ovarian cDNA expression database to collect 41 patient samples and 9600 genes in each pathological stage. Feature selection methods were used to detect and extract 15 notable oncogenes. We then used the DfABC-SVM model to examine these 15 oncogenes, dividing them into eight different classifications according to their gene expressions of various pathological stages. The average accuracyof the eight classification experiments was 94.76%. This research also found some oncogenes that had not been discovered or indicated in previous scientific studies. The main contribution of this research is the proof that these newly discovered oncogenes are highly related to ovarian or other cancers. AVAILABILITY AND IMPLEMENTATION: http://mht.mis.nchu.edu.tw/moodle/course/view.php?id=7.