The manual assessment of brain Magnetic Resonance Imaging (MRI) scans can be labor-intensive and time-consuming for radiologists. Deep Learning methods have demonstrated the potential to aid this process. However, their effectiveness relies on the availability of large, annotated data sets. Unsupervised Anomaly Detection (UAD) presents a promising alternative, offering the potential to identify and localize anomalies without per-pixel annotations. Instead, a normative distribution is learned using healthy data, enabling the identification of abnormalities as deviations. This allows UAD methods to detect abnormalities that were unseen during training. This appealing feature has led to numerous studies proposing innovations and novel approaches. In this work, we provide a review of the literature and systematically collect and compare the proposed approaches. We observe that UAD has made significant advancements in brain MRI analysis. However, individual approaches are often evaluated in different contexts, i.e., changes in acquisition parameters, pre- and post-processing, and anomaly scoring. This variability makes it challenging to assess which models perform best, underscoring the need for comprehensive comparative studies concerning the specific context of MRI scans. Our collection, featuring public data sets, research studies, and open implementations, is available at our GitHub repository https://github.com/FinnBehrendt/Unsupervised-Anomaly-Detection-in-Brain-MRI.

Statistical shape and appearance models are often based on the accurate identification of one-to-one correspondences in a training data set. At the same time, the determination of these corresponding landmarks is the most challenging part of such methods. Hufnagel etal developed an alternative method using correspondence probabilities for a statistical shape model. We propose the use of probabilistic correspondences for statistical appearance models by incorporating appearance information into the framework. A point-based representation is employed representing the image by a set of vectors assembling position and appearances. Using probabilistic correspondences between these multi-dimensional feature vectors eliminates the need for extensive preprocessing to find corresponding landmarks and reduces the dependence of the generated model on the landmark positions. Then, a maximum a-posteriori approach is used to derive a single global optimization criterion with respect to model parameters and observation dependent parameters, that directly affects shape and appearance information of the considered structures. Model generation and fitting can be expressed by optimizing the same criterion. The developed framework describes the modeling process in a concise and flexible mathematical way and allows for additional constraints as topological regularity in the modeling process. Furthermore, it eliminates the demand for costly correspondence determination. We apply the model for segmentation and landmark identification in hand X-ray images, where segmentation information is modeled as further features in the vectorial image representation. The results demonstrate the feasibility of the model to reconstruct contours and landmarks for unseen test images. Furthermore, we apply the model for tissue classification, where a model is generated for healthy brain tissue using 2D MRI slices. Applying the model to images of stroke patients the probabilistic correspondences are used to classify between healthy and pathological structures. The results demonstrate the ability of the probabilistic model to recognize healthy and pathological tissue automatically.

We report on the investigation on acted and non-acted emotional speech and the resulting Non-/acted LAST MINUTE corpus (NaLMC) database. The database consists of newly recorded acted emotional speech samples which were designed to allow the direct comparison of acted and non-acted emotional speech. The non-acted samples are taken from the LAST MINUTE corpus (LMC) [1]. Furthermore, emotional labels were added to selected passages of the LMC and a self-rating of the LMC recordings was performed. Although the main objective of the NaLMC database is to allow the comparative analysis of acted and non-acted emotional speech, both audio and video signals were recorded to allow multimodal investigations.