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John McClure

dblp:11/2993 · DBLP profile ↗
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2ranked-venue papers
0as first author
0since 2021 · last 2003
—ORCID · unresolved

Domains — the database's venue-derived domains; a paper can count in several

Applied, interdisciplinary, general and emerging computing · 2Graphics, computer vision, multimedia, augmented reality and games · 1

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
1 paper
Bioinformatics and computational biology · 100%

Topics — the 2 heaviest of 2, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Bioinformatics and computational biology
gene expression analysis
0.012003
Statistical Adjustment of Signal Censoring in Gene Expression Experiments · Bioinform. 2003
Bioinformatics and computational biology › gene expression analysis
microarray data preprocessing
0.012003
Statistical Adjustment of Signal Censoring in Gene Expression Experiments · Bioinform. 2003

Methods — techniques the papers use, named apart from their topics

maximum likelihood estimation · 0.0log-normal distribution · 0.0gamma distribution · 0.0
YearPublicationVenuePosition
2003 Determination of the Mechanical Properties of Soft Human Tissues through Aspiration Experiments
Alessandro Nava, Edoardo Mazza, Frederic Kleinermann, Nick J. Avis, John McClure
MICCAI (1)5
2003 Statistical Adjustment of Signal Censoring in Gene Expression Experiments
abstract
MOTIVATION: Numerical output of spotted microarrays displays censoring of pixel intensities at some software dependent threshold. This reduces the quality of gene expression data, because it seriously violates the linearity of expression with respect to signal intensity. Statistical methods based on typically available spot summaries together with some parametric assumptions can suggest ways to correct for this defect. RESULTS: A maximum likelihood approach is suggested together with a sensible approximation to the joint density of the mean, median and variance-which are typically available to the biological end-user. The method 'corrects' the gene expression values for pixel censoring. A by-product of our approach is a comparison between several two-parameter models for pixel intensity values. It suggests that pixels separated by one or two other pixels can be considered independent draws from a Lognormal or a Gamma distribution. AVAILABILITY: The R/S-Plus code is available at http://www.stats.gla.ac.uk/~microarray/software.
Ernst Wit, John McClure
Bioinform.2