Driven by clinical needs and progress in neurotechnology, targeted interaction with neuronal networks is of increasing importance. Yet, the dynamics of interaction between intrinsic ongoing activity in neuronal networks and their response to stimulation is unknown. Nonetheless, electrical stimulation of the brain is increasingly explored as a therapeutic strategy and as a means to artificially inject information into neural circuits. Strategies using regular or event-triggered fixed stimuli discount the influence of ongoing neuronal activity on the stimulation outcome and are therefore not optimal to induce specific responses reliably. Yet, without suitable mechanistic models, it is hardly possible to optimize such interactions, in particular when desired response features are network-dependent and are initially unknown. In this proof-of-principle study, we present an experimental paradigm using reinforcement-learning (RL) to optimize stimulus settings autonomously and evaluate the learned control strategy using phenomenological models. We asked how to (1) capture the interaction of ongoing network activity, electrical stimulation and evoked responses in a quantifiable 'state' to formulate a well-posed control problem, (2) find the optimal state for stimulation, and (3) evaluate the quality of the solution found. Electrical stimulation of generic neuronal networks grown from rat cortical tissue in vitro evoked bursts of action potentials (responses). We show that the dynamic interplay of their magnitudes and the probability to be intercepted by spontaneous events defines a trade-off scenario with a network-specific unique optimal latency maximizing stimulus efficacy. An RL controller was set to find this optimum autonomously. Across networks, stimulation efficacy increased in 90% of the sessions after learning and learned latencies strongly agreed with those predicted from open-loop experiments. Our results show that autonomous techniques can exploit quantitative relationships underlying activity-response interaction in biological neuronal networks to choose optimal actions. Simple phenomenological models can be useful to validate the quality of the resulting controllers.

In this paper we present a fully automated approach to (approximate) optimal control of non-linear systems. Our algorithm jointly learns a non-parametric model of the system dynamics - based on Gaussian Process Regression (GPR) - and performs receding horizon control using an adapted iterative LQR formulation. This results in an extremely data-efficient learning algorithm that can operate under real-time constraints. When combined with an exploration strategy based on GPR variance, our algorithm successfully learns to control two benchmark problems in simulation (two-link manipulator, cart-pole) as well as to swing-up and balance a real cart-pole system. For all considered problems learning from scratch, that is without prior knowledge provided by an expert, succeeds in less than 10 episodes of interaction with the system.

In this work we address the problem of feature extraction for object recognition in the context of cameras providing RGB and depth information (RGB-D data). We consider this problem in a bag of features like setting and propose a new, learned, local feature descriptor for RGB-D images, the convolutional k-means descriptor. The descriptor is based on recent results from the machine learning community. It automatically learns feature responses in the neighborhood of detected interest points and is able to combine all available information, such as color and depth into one, concise representation. To demonstrate the strength of this approach we show its applicability to different recognition problems. We evaluate the quality of the descriptor on the RGB-D Object Dataset where it is competitive with previously published results and propose an embedding into an image processing pipeline for object recognition and pose estimation.