Feature extraction is a critical component of many applied data science workflows. In recent years, rapid advances in artificial intelligence and machine learning have led to an explosion of feature extraction tools and services that allow data scientists to cheaply and effectively annotate their data along a vast array of dimensions--ranging from detecting faces in images to analyzing the sentiment expressed in coherent text. Unfortunately, the proliferation of powerful feature extraction services has been mirrored by a corresponding expansion in the number of distinct interfaces to feature extraction services. In a world where nearly every new service has its own API, documentation, and/or client library, data scientists who need to combine diverse features obtained from multiple sources are often forced to write and maintain ever more elaborate feature extraction pipelines. To address this challenge, we introduce a new open-source framework for comprehensive multimodal feature extraction. Pliers is an open-source Python package that supports standardized annotation of diverse data types (videos, images, audio, and text), and is expressly implemented with both ease-of-use and extensibility in mind. Users can apply a wide range of pre-existing feature extraction tools to their data in just a few lines of Python code, and can also easily add their own custom extractors by writing modular classes. A graph-based API enables rapid development of feature extraction pipelines that output results in a single, standardized format. We describe the package's architecture, detail its advantages over previous feature extraction toolboxes, and use a sample application to a large functional MRI dataset to illustrate how pliers can significantly reduce the time and effort required to construct simple feature extraction workflows while increasing code clarity and maintainability.

The rate of progress in human neurosciences is limited by the inability to easily apply a wide range of analysis methods to the plethora of different datasets acquired in labs around the world. In this work, we introduce a framework for creating, testing, versioning and archiving portable applications for analyzing neuroimaging data organized and described in compliance with the Brain Imaging Data Structure (BIDS). The portability of these applications (BIDS Apps) is achieved by using container technologies that encapsulate all binary and other dependencies in one convenient package. BIDS Apps run on all three major operating systems with no need for complex setup and configuration and thanks to the comprehensiveness of the BIDS standard they require little manual user input. Previous containerized data processing solutions were limited to single user environments and not compatible with most multi-tenant High Performance Computing systems. BIDS Apps overcome this limitation by taking advantage of the Singularity container technology. As a proof of concept, this work is accompanied by 22 ready to use BIDS Apps, packaging a diverse set of commonly used neuroimaging algorithms.

A central goal of cognitive neuroscience is to decode human brain activity-that is, to infer mental processes from observed patterns of whole-brain activation. Previous decoding efforts have focused on classifying brain activity into a small set of discrete cognitive states. To attain maximal utility, a decoding framework must be open-ended, systematic, and context-sensitive-that is, capable of interpreting numerous brain states, presented in arbitrary combinations, in light of prior information. Here we take steps towards this objective by introducing a probabilistic decoding framework based on a novel topic model-Generalized Correspondence Latent Dirichlet Allocation-that learns latent topics from a database of over 11,000 published fMRI studies. The model produces highly interpretable, spatially-circumscribed topics that enable flexible decoding of whole-brain images. Importantly, the Bayesian nature of the model allows one to "seed" decoder priors with arbitrary images and text-enabling researchers, for the first time, to generate quantitative, context-sensitive interpretations of whole-brain patterns of brain activity.

This paper presents Generalized Correspondence-LDA (GC-LDA), a generalization of the Correspondence-LDA model that allows for variable spatial representations to be associated with topics, and increased flexibility in terms of the strength of the correspondence between data types induced by the model. We present three variants of GC-LDA, each of which associates topics with a different spatial representation, and apply them to a corpus of neuroimaging data. In the context of this dataset, each topic corresponds to a functional brain region, where the region's spatial extent is captured by a probability distribution over neural activity, and the region's cognitive function is captured by a probability distribution over linguistic terms. We illustrate the qualitative improvements offered by GC-LDA in terms of the types of topics extracted with alternative spatial representations, as well as the model's ability to incorporate a-priori knowledge from the neuroimaging literature. We furthermore demonstrate that the novel features of GC-LDA improve predictions for missing data.

Neuroimaging research has largely focused on the identification of associations between brain activation and specific mental functions. Here we show that data mining techniques applied to a large database of neuroimaging results can be used to identify the conceptual structure of mental functions and their mapping to brain systems. This analysis confirms many current ideas regarding the neural organization of cognition, but also provides some new insights into the roles of particular brain systems in mental function. We further show that the same methods can be used to identify the relations between mental disorders. Finally, we show that these two approaches can be combined to empirically identify novel relations between mental disorders and mental functions via their common involvement of particular brain networks. This approach has the potential to discover novel endophenotypes for neuropsychiatric disorders and to better characterize the structure of these disorders and the relations between them.