Optical aberrations significantly degrade image quality in microscopy, particularly when imaging deeper into samples. These aberrations arise from distortions in the optical wavefront and can be mathematically represented using Zernike polynomials. Existing methods often address only mild aberrations on limited sample types and modalities, typically treating the problem as a black-box mapping without leveraging the underlying optical physics of wavefront distortions. We propose ZRNet, a physics-informed framework that jointly performs Zernike coefficient prediction and optical image Restoration. We contribute a Zernike Graph module that explicitly models physical relationships between Zernike polynomials based on their azimuthal degrees—ensuring that learned corrections align with fundamental optical principles. To further enforce physical consistency between image restoration and Zernike prediction, we introduce a Frequency-Aware Alignment (FAA) loss, which better aligns Zernike coefficient prediction and image features in the Fourier domain. Extensive experiments on CytoImageNet demonstrates that our approach achieves state-of-the-art performance in both image restoration and Zernike coefficient prediction across diverse microscopy modalities and biological samples with complex, large-amplitude aberrations. We further validate on experimental PSF data from a physical microscope and demonstrate robustness to realistic sensor noise, confirming generalisation beyond simulated conditions. Code is available at https://github.com/janetkok/ZRNet .

Zero-Shot object counting aims to count instances of arbitrary object categories specified by text descriptions. Existing methods typically rely on vision-language models like CLIP, but often exhibit limited sensitivity to text prompts. We present T21 Count, a diffusion-based framework that lever-ages rich prior knowledge and fine-grained visual understanding from pretrained diffusion models. While one-step demising ensures efficiency, it leads to weakened text sensitivity. To address this challenge, we propose a Hierarchical Semantic Correction Module that progressively refines text-image feature alignment, and a Representational Regional Coherence Loss that provides reliable supervision signals by leveraging the cross-attention maps extracted from the demising U-Net. Furthermore, we observe that current benchmarks mainly focus on majority objects in images, potentially masking models' text sensitivity. To address this, we contribute a challenging re-annotated subset of FSC147 for better evaluation of text-guided counting ability. Extensive experiments demonstrate that our method achieves superior performance across different benchmarks. Code is available at https://github.com/chal5yq/T2lCount.

Saliency ranking detection (SRD) has emerged as a challenging task in computer vision, aiming not only to identify salient objects within images but also to rank them based on their degree of saliency. Existing SRD datasets have been created primarily using mouse-trajectory data, which inadequately captures the intricacies of human visual perception. Addressing this gap, this paper introduces the first large-scale SRD dataset, SIFR, constructed using genuine human fixation data, thereby aligning more closely with real visual perceptual processes. To establish a baseline for this dataset, we propose QAGNet, a novel model that leverages salient instance query features from a transformer detector within a tri-tiered nested graph. Through extensive experiments, we demonstrate that our approach outperforms existing state-of-the-art methods across two widely used SRD datasets and our newly proposed dataset. Code and dataset are available at https://github.com/EricDengbowen/QAGNet.

Salient object detection plays an important role in many downstream tasks. However, complex real-world scenes with varying scales and numbers of salient objects still pose a challenge. In this paper, we directly address the problem of detecting multiple salient objects across complex scenes. We propose a network architecture incorporating non-local feature information in both the spatial and channel spaces, capturing the long-range dependencies between separate objects. Traditional bottom-up and non-local features are combined with edge features within a feature fusion gate that progressively refines the salient object prediction in the decoder. We show that our approach accurately locates multiple salient regions even in complex scenarios. To demonstrate the efficacy of our approach to the multiple salient objects problem, we curate a new dataset containing only multiple salient objects. Our experiments demonstrate the proposed method presents state-of-the-art results on five widely used datasets without any pre-processing and post-processing. We obtain a further performance improvement against competing techniques on our multi-objects dataset. The dataset and source code are available at: https://github.com/EricDengbowen/DSLRDNet.