The problems of a 7-degree of freedom (DOF) manipulator with rapid and continuous response to uncertain fast-flying objects are addressed: 1) how to effectively solve trajectory planning of the 7-DOF manipulator with multiple criteria; and 2) how to make the 7-DOF manipulator realize the rapid and continuous response to uncertain fast-flying objects. In the proposed approach, based on the trajectory parameterization of the 7-DOF manipulator, a multiobjective teaching-learning-based optimization (MOTLBO) algorithm is adopted to find a close representation of the Pareto optimal set rather than a single solution. As such, an optimal solution can be chosen as digital knowledge information. A new methodology based on a knowledge base representing and learning the operation environment, that is, skill digitization, is presented, which enables the 7-DOF manipulator to realize the rapid and continuous response skill. Simulation and practical testing results of a ping-pong robot validate the feasibility and effectiveness of the proposed approach, in which the online trajectory generation spends only around 1 ms.