Corner cases are crucial for training and validating autonomous driving systems, yet collecting them from the real world is often costly and hazardous. Editing objects within captured sensor data offers an effective alternative for generating diverse scenarios, commonly achieved through 3D Gaussian Splatting or image generative models. However, these approaches often suffer from limited visual fidelity or imprecise pose control. To address these issues, we propose G^2Editor, a framework designed for photorealistic and precise object editing in driving videos. Our method leverages a 3D Gaussian representation of the edited object as a dense prior, injected into the denoising process to ensure accurate pose control and spatial consistency. A scene-level 3D bounding box layout is employed to reconstruct occluded areas of non-target objects. Furthermore, to guide the appearance details of the edited object, we incorporate hierarchical fine-grained features as additional conditions during generation. Experiments on the Waymo Open Dataset demonstrate that G^2Editor effectively supports object repositioning, insertion, and deletion within a unified framework, outperforming existing methods in both pose controllability and visual quality, while also benefiting downstream data-driven tasks.

Convolutional neural networks (CNNs) have shown excellent performance for vision-based lane detection. However, maintaining the performance of the trained models under new test scenarios still remains challenging due to the dataset bias between the training and test datasets; In lane detection processes, the dataset bias can be categorized into lane position bias and lane pattern bias, with the former one particularly influences the lane detection performance. To tackle this dataset bias, this article proposes aunified viewpoint transformation (UVT)method that transforms the camera viewpoints of different datasets into a common virtual world coordinate system, such that the mismatched lane position distributions can be effectively aligned. Experiments are conducted on multiple datasets including the Caltech[1], Tusimple[2], and KITTI[3]dataset. The results demonstrate the effectiveness of the UVT algorithm in improving the lane detection performance on the test datasets. Moreover, by incorporating the UVT into other techniques that tackling the dataset bias, the lane position and pattern differences are disentangled and separately minimized. As a result, the performance gap between the training data and the test scenarios can be bridged. Specifically, the model trained on the KITTI dataset have achieved high performance in the Tusimple and the Caltech dataset (F1-score: 84.8 and 87.1%). With the proposed algorithm, a lane detection model trained on one dataset can be effectively applied to datasets with different camera settings in vastly different localities, and achieve better generalization ability compared to the state of the art methods.

Optimal velocity (OV)-based car-following model can be easily applied to the transportation system composed of intelligent connected vehicle (ICV) via vehicle-to-vehicle (V2V) communication, since this model only requires space headway and velocity differences of preceding vehicles. However, the sudden velocity changes of the leading vehicle will decrease the control performance of following vehicles. Particularly, the farther the distance between the following vehicle and the leading vehicle is, the worse the control performance of the following vehicle is. Besides this problem, the nonlinear information of OV-based car-following models is often not fully utilized due to the linearization for the convenience of stability analysis and controller design. To address these problems, the factors related to velocity sudden changes are taken into account for each ICV simultaneously and compensated by the proposed feedforward compensator. Based on the compensator, a finite-time traffic flow controller is designed for each ICV to smooth the space headway in traffic flow subject to sudden velocity changes and make full use of the nonlinear information of OV-based model. Finally, the theoretical analysis via Lyapunov approach and the numerical simulations are carried out to verify the effectiveness of the proposed method.

MOTIVATION: The significance of long non-coding RNAs (lncRNAs) in many biological processes and diseases has gained intense interests over the past several years. However, computational identification of lncRNAs in a wide range of species remains challenging; it requires prior knowledge of well-established sequences and annotations or species-specific training data, but the reality is that only a limited number of species have high-quality sequences and annotations. RESULTS: Here we first characterize lncRNAs in contrast to protein-coding RNAs based on feature relationship and find that the feature relationship between open reading frame length and guanine-cytosine (GC) content presents universally substantial divergence in lncRNAs and protein-coding RNAs, as observed in a broad variety of species. Based on the feature relationship, accordingly, we further present LGC, a novel algorithm for identifying lncRNAs that is able to accurately distinguish lncRNAs from protein-coding RNAs in a cross-species manner without any prior knowledge. As validated on large-scale empirical datasets, comparative results show that LGC outperforms existing algorithms by achieving higher accuracy, well-balanced sensitivity and specificity, and is robustly effective (>90% accuracy) in discriminating lncRNAs from protein-coding RNAs across diverse species that range from plants to mammals. To our knowledge, this study, for the first time, differentially characterizes lncRNAs and protein-coding RNAs based on feature relationship, which is further applied in computational identification of lncRNAs. Taken together, our study represents a significant advance in characterization and identification of lncRNAs and LGC thus bears broad potential utility for computational analysis of lncRNAs in a wide range of species. AVAILABILITY AND IMPLEMENTATION: LGC web server is publicly available at http://bigd.big.ac.cn/lgc/calculator. The scripts and data can be downloaded at http://bigd.big.ac.cn/biocode/tools/BT000004. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Occupancy grids have shown interesting properties to model the environment for intelligent vehicles perception. In this paper, we present a novel approach to build 2D occupancy grid maps with stereo-vision. Our approach proposes a fitted sensor model based on the disparity space to interpret the stereo-vision information onto an occupancy grid map. The evidential model deals with sensor uncertainties by using Dempster-Shafer theory. Our approach exploits the U-disparity space to model the obstacle information and the V-disparity space to model the road space information. The fusion of these two sources of complementary information results to an enhanced environmental model. In a first experimental data set, results based on real road data and comparisons with Lidar grids show that the proposed evidential sensor model can model efficiently the environment. In a second one, the mapping of a road environment is reported to show the performance of the proposed model with another stereo-vision system.

For the development of driving assistance systems and autonomous vehicles, a reference perception equipment including navigable space determination and obstacles detection is a key issue. The Velodyne sensor which provides high definition and omnidirectional information can be used for this purpose. Nevertheless, when scanning around the vehicle, uncertainty necessarily arises due to unperceived areas and noisy measurements. This paper proposes an inverse evidential model for the Velodyne in order to exploit its measurements in a 2D occupancy grid mapping framework. The evidential sensor model interprets the data acquired from the Velodyne and successively maps it to a Carthesian evidential grid using a fusion process based on the least commitment principle to guarantee information integrity. Experimental results prove that this approach can handle efficiently the uncertainties of the sensor and thus a highly reliable local reference map near the vehicle can be built for every timestamped perception system that needs evaluation or calibration.

BACKGROUND: Interferon-gamma (IFN-gamma) and interleukin-6 (IL-6) are multifunctional cytokines that regulate immune responses, cell proliferation, and tumour development and progression, which frequently have functionally opposing roles. The cellular responses to both cytokines are activated via the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. During the past 10 years, the crosstalk mechanism between the IFN-gamma and IL-6 pathways has been studied widely and several biological hypotheses have been proposed, but the kinetics and detailed crosstalk mechanism remain unclear. RESULTS: Using established mathematical models and new experimental observations of the crosstalk between the IFN-gamma and IL-6 pathways, we constructed a new crosstalk model that considers three possible crosstalk levels: (1) the competition between STAT1 and STAT3 for common receptor docking sites; (2) the mutual negative regulation between SOCS1 and SOCS3; and (3) the negative regulatory effects of the formation of STAT1/3 heterodimers. A number of simulations were tested to explore the consequences of cross-regulation between the two pathways. The simulation results agreed well with the experimental data, thereby demonstrating the effectiveness and correctness of the model. CONCLUSION: In this study, we developed a crosstalk model of the IFN-gamma and IL-6 pathways to theoretically investigate their cross-regulation mechanism. The simulation experiments showed the importance of the three crosstalk levels between the two pathways. In particular, the unbalanced competition between STAT1 and STAT3 for IFNR and gp130 led to preferential activation of IFN-gamma and IL-6, while at the same time the formation of STAT1/3 heterodimers enhanced preferential signal transduction by sequestering a fraction of the activated STATs. The model provided a good explanation of the experimental observations and provided insights that may inform further research to facilitate a better understanding of the cross-regulation mechanism between the two pathways.