Scanpath similarity metrics are central to eye-movement research, yet existing methods predominantly evaluate spatial and temporal alignment while neglecting semantic equivalence between attended image regions. We present a semantic scanpath similarity framework that integrates vision-language models (VLMs) into eye-tracking analysis. Each fixation is encoded under controlled visual context (patch-based and marker-based strategies) and transformed into concise textual descriptions, which are aggregated into scanpath-level representations. Semantic similarity is then computed using embedding-based and lexical NLP metrics and compared against established spatial measures, including MultiMatch and DTW. Experiments on free-viewing eye-tracking data demonstrate that semantic similarity captures partially independent variance from geometric alignment, revealing cases of high content agreement despite spatial divergence. We further analyze the impact of contextual encoding on description fidelity and metric stability. Our findings suggest that multimodal foundation models enable interpretable, content-aware extensions of classical scanpath analysis, providing a complementary dimension for gaze research within the ETRA community.

We introduce GazeVaLM, a public eye-tracking dataset for studying clinical perception during chest radiograph authenticity assessment. The dataset comprises 960 gaze recordings from 16 expert radiologists interpreting 30 real and 30 synthetic chest X-rays (generated by diffusion based generative AI) under two conditions: diagnostic assessment and real-fake classification (Visual Turing test). For each image–observer pair, we provide raw gaze samples, fixation maps, scanpaths, saliency density maps, structured diagnostic labels, and authenticity judgments. We extend the protocol to 6 state-of-the-art multimodal LLMs, releasing their predicted diagnoses, authenticity labels, and confidence scores under matched conditions — enabling direct human–AI comparison at both decision and uncertainty levels. We further provide analyses of gaze agreement, inter-observer consistency, and benchmarking of radiologists versus LLMs in diagnostic accuracy and authenticity detection. GazeVaLM supports research in gaze modeling, clinical decision-making, human–AI comparison, generative image realism assessment, and uncertainty quantification. By jointly releasing visual attention data, clinical labels, and model predictions, we aim to facilitate reproducible research on how experts and AI systems perceive, interpret, and evaluate medical images. The dataset is available at https://huggingface.co/datasets/davidcwong/GazeVaLM.

Temporal awareness is essential for video large language models (LLMs) to understand and reason about events within long videos, enabling applications like dense video captioning and temporal video grounding in a unified system. However, the scarcity of long videos with detailed captions and precise temporal annotations limits their temporal awareness. In this paper, we propose Seq2Time, a data-oriented training paradigm that leverages sequences of images and short video clips to enhance temporal awareness in long videos. By converting sequence positions into temporal annotations, we transform large-scale image and clip captioning datasets into sequences that mimic the temporal structure of long videos, enabling self-supervised training with abundant time-sensitive data. To enable sequence-to-time knowledge transfer, we introduce a novel time representation that unifies positional information across image sequences, clip sequences, and long videos. Experiments demonstrate the effectiveness of our method, achieving a 27.6% improvement in F1 score and 44.8% in CIDEr on the YouCook2 benchmark and a 14.7% increase in recall on the Charades-STA benchmark compared to the baseline. Project available at: https://seq2time.github.io/

Accurate segmentation of organs from abdominal CT scans is essential for clinical applications such as diagnosis, treatment planning, and patient monitoring. To handle challenges of heterogeneity in organ shapes, sizes, and complex anatomical relationships, we propose a Multi decoder network (MDNet), an encoder-decoder network that uses the pre-trained MiT-B2 as the encoder and multiple different decoder networks. Each decoder network is connected to a different part of the encoder via a multi-scale feature enhancement dilated block. With each decoder, we increase the depth of the network iteratively and refine segmentation masks, enriching feature maps by integrating previous decoders’ feature maps. To refine the feature map further, we also utilize the predicted masks from the previous decoder to the current decoder to provide spatial attention across foreground and background regions. MDNet effectively refines the segmentation mask with a high dice similarity coefficient (DSC) of 0.9013 and 0.9169 on the Liver Tumor segmentation (LiTS) and MSD Spleen datasets. Additionally, it reduces Hausdorff distance (HD) to 3.79 for the LiTS dataset and 2.26 for the spleen segmentation dataset, underscoring the precision of MDNet in capturing the complex contours. Moreover, MDNet is more interpretable and robust compared to the other baseline models. The code for our architecture is available at https://github.com/DebeshJha/MDNet.

Interactive segmentation aims to accurately segment target objects with minimal user interactions. However, current methods often fail to accurately separate target objects from the background, due to a limited understanding of order, the relative depth between objects in a scene. To address this issue, we propose OIS: order-aware interactive segmentation, where we explicitly encode the relative depth between objects into order maps. We introduce a novel order-aware attention, where the order maps seamlessly guide the user interactions (in the form of clicks) to attend to the image features. We further present an object-aware attention module to incorporate a strong object-level understanding to better differentiate objects with similar order. Our approach allows both dense and sparse integration of user clicks, enhancing both accuracy and efficiency as compared to prior works. Experimental results demonstrate that OIS achieves state-of-the-art performance, improving mIoU after one click by 7.61 on the HQSeg44K dataset and 1.32 on the DAVIS dataset as compared to the previous state-of-the-art SegNext, while also doubling inference speed compared to current leading methods.

Automated volumetric segmentation of the pancreas on cross-sectional imaging is needed for diagnosis and follow-up of pancreatic diseases. While CT-based pancreatic segmentation is more established, MRI-based segmentation methods are understudied, largely due to a lack of publicly available datasets, benchmarking research efforts, and domain-specific deep learning methods. In this retrospective study, we collected a large dataset (767 scans from 499 participants) of T1-weighted (T1 W) and T2-weighted (T2 W) abdominal MRI series from five centers between March 2004 and November 2022. We also collected CT scans of 1,350 patients from publicly available sources for benchmarking purposes. We introduced a new pancreas segmentation method, called PanSegNet , combining the strengths of nnUNet and a Transformer network with a new linear attention module enabling volumetric computation. We tested PanSegNet ’s accuracy in cross-modality (a total of 2,117 scans) and cross-center settings with Dice and Hausdorff distance (HD95) evaluation metrics. We used Cohen’s kappa statistics for intra and inter-rater agreement evaluation and paired t-tests for volume and Dice comparisons, respectively. For segmentation accuracy, we achieved Dice coefficients of 88.3% (±7.2%, at case level) with CT, 85.0% (±7.9%) with T1 W MRI, and 86.3% (±6.4%) with T2 W MRI. There was a high correlation for pancreas volume prediction with R 2 of 0.91, 0.84, and 0.85 for CT, T1 W, and T2 W, respectively. We found moderate inter-observer (0.624 and 0.638 for T1 W and T2 W MRI, respectively) and high intra-observer agreement scores. All MRI data is made available at https://osf.io/kysnj/ . Our source code is available at https://github.com/NUBagciLab/PaNSegNet . • We develop a first-ever cross-platform compatible (T1 W, T2 W, and CT) pancreas segmentation tool, named PanSegNet . • PaNSegNet has innovative “linear self-attention” blocks to reduce computational cost significantly while operating on 3D. • We shared our both source code and multi-center multi-contrast MRI datasets with ground truths. • PaNSegNet underwent rigorous validation, including cross-domain and multi-center comparisons between CT and MRI scans.

Alignment between human knowledge and machine learning models is crucial for achieving efficient and interpretable AI systems. However, conventional self-supervised pre-training methods often suffer from low efficiency, as they do not incorporate human knowledge during the pre-training process and instead rely mainly on post-hoc alignment techniques. We propose Gaze Pre-Training (GzPT), a novel approach that introduces early alignment with human eye gaze information during the pre-training process to enhance both the learning efficiency and performance of self-supervised models. By leveraging contrastive learning to pull together images with similar gaze patterns, GzPT can effectively align the model with human attention during the pre-training. We demonstrate the effectiveness of our approach on three diverse medical image datasets, showing that GzPT can consistently outperform baseline methods and learn more meaningful and interpretable representations. Our findings also highlight the potential of incorporating human eye gaze as a form of passive knowledge to bridge the gap between human and machine learning in the self-supervised pre-training. Our code is available at Github.

Large-scale, big-variant, high-quality data are crucial for developing robust and successful deep-learning models for medical applications since they potentially enable better generalization performance and avoid overfitting. However, the scarcity of high-quality labeled data always presents significant challenges. This paper proposes a novel approach to address this challenge by developing controllable diffusion models for medical image synthesis, called DiffBoost. We leverage recent diffusion probabilistic models to generate realistic and diverse synthetic medical image data that preserve the essential characteristics of the original medical images by incorporating edge information of objects to guide the synthesis process. In our approach, we ensure that the synthesized samples adhere to medically relevant constraints and preserve the underlying structure of imaging data. Due to the random sampling process by the diffusion model, we can generate an arbitrary number of synthetic images with diverse appearances. To validate the effectiveness of our proposed method, we conduct an extensive set of medical image segmentation experiments on multiple datasets, including Ultrasound breast (+13.87%), CT spleen (+0.38%), and MRI prostate (+7.78%), achieving significant improvements over the baseline segmentation methods. The promising results demonstrate the effectiveness of our DiffBoost for medical image segmentation tasks and show the feasibility of introducing a first-ever text-guided diffusion model for general medical image segmentation tasks. With carefully designed ablation experiments, we investigate the influence of various data augmentations, hyper-parameter settings, patch size for generating random merging mask settings, and combined influence with different network architectures. Source code with checkpoints are available at https://github.com/NUBagciLab/DiffBoost.

Domain generalization aims to train models on multiple source domains so that they can generalize well to unseen target domains. Among many domain generalization methods, Fourier-transformbased domain generalization methods have gained popularity primarily because they exploit the power of Fourier transformation to capture essential patterns and regularities in the data, making the model more robust to domain shifts. The mainstream Fouriertransform-based domain generalization swaps the Fourier amplitude spectrum while preserving the phase spectrum between the source and the target images. However, it neglects background interference in the amplitude spectrum. To overcome this limitation, we introduce a soft-thresholding function in the Fourier domain. We apply this newly designed algorithm to retinal fundus image segmentation, which is important for diagnosing ocular diseases but the neural network’s performance can degrade across different sources due to domain shifts. The proposed technique basically enhances fundus image augmentation by eliminating small values in the Fourier domain and providing better generalization. The innovative nature of the soft thresholding fused with Fourier-transform-based domain generalization improves neural network models’ performance by reducing the target images’ background interference significantly. Experiments on public data validate our approach’s effectiveness over conventional and state-of-the-art methods with superior segmentation metrics.

Eye tracking research is important in computer vision because it can help us understand how humans interact with the visual world. Specifically for high-risk applications, such as in medical imaging, eye tracking can help us to comprehend how radiologists and other medical professionals search, analyze, and interpret images for diagnostic and clinical purposes. Hence, the application of eye tracking techniques in disease classification has become increasingly popular in recent years. Contemporary works usually transform gaze information collected by eye tracking devices into visual attention maps (VAMs) to supervise the learning process. However, this is a time-consuming preprocessing step, which stops us from applying eye tracking to radiologists’ daily work. To solve this problem, we propose a novel gaze-guided graph neural network (GNN), GazeGNN, to leverage raw eye-gaze data without being converted into VAMs. In GazeGNN, to directly integrate eye gaze into image classification, we create a unified representation graph that models both images and gaze pattern information. With this benefit, we develop a real-time, real-world, end-to-end disease classification algorithm for the first time in the literature. This achievement demonstrates the practicality and feasibility of integrating real-time eye tracking techniques into the daily work of radiologists. To our best knowledge, GazeGNN is the first work that adopts GNN to integrate image and eye-gaze data. Our experiments on the public chest X-ray dataset show that our proposed method exhibits the best classification performance compared to existing methods. The code is available at https://github.com/ukaukaaaa/GazeGNN.

Domain generalization (DG) approaches intend to extract domain invariant features that can lead to a more robust deep learning model. In this regard, style augmentation is a strong DG method taking advantage of instance-specific feature statistics containing informative style characteristics to synthetic novel domains. While it is one of the state-of-the-art methods, prior works on style augmentation have either disregarded the interdependence amongst distinct feature channels or have solely constrained style augmentation to linear interpolation. To address these research gaps, in this work, we introduce a novel augmentation approach, named Correlated Style Uncertainty (CSU), surpassing the limitations of linear interpolation in style statistic space and simultaneously preserving vital correlation information. Our method's efficacy is established through extensive experimentation on diverse cross-domain computer vision and medical imaging classification tasks: PACS, Office-Home, and Camelyon17 datasets, and the Duke-Market1501 instance retrieval task. The results showcase a remarkable improvement margin over existing state-of-the-art techniques. The source code is available https://github.com/freshman97/CSU.