Classifying entities in domain ontologies under upper ontology classes is a recommended task in ontology engineering to facilitate semantic interoperability and modelling consistency. Integrating upper ontologies this way is difficult and, despite emerging automated methods, remains a largely manual task. Little is known about how well experts perform at upper ontology integration. To develop methodological and tool support, we first need to understand how well experts do this task. We designed a study to measure the performance of human experts at manually classifying classes in a general knowledge domain ontology with entities in the Basic Formal Ontology (BFO), an upper ontology used widely in the biomedical domain. We recruited 8 BFO experts and asked them to classify 46 commonly known entities from the domain of travel with BFO entities. The tasks were delivered as part of a web survey. We find that, even for a well understood general knowledge domain such as travel, the results of the manual classification tasks are highly inconsistent: the mean agreement of the participants with the classification decisions of an expert panel was only 51%, and the inter-rater agreement using Fleiss’ Kappa was merely moderate (0.52). We further follow up on the conjecture that the degree of classification consistency is correlated with the frequency the respective BFO classes are used in practice and find that this is only true to a moderate degree (0.52, Pearson). We conclude that manually classifying domain entities under upper ontology classes is indeed very difficult to do correctly. Given the importance of the task and the high degree of inconsistent classifications we encountered, we further conclude that it is necessary to improve the methodological framework surrounding the manual integration of domain and upper ontologies.

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MOTIVATION: Resource description framework (RDF) is an emerging technology for describing, publishing and linking life science data. As a major provider of bioinformatics data and services, the European Bioinformatics Institute (EBI) is committed to making data readily accessible to the community in ways that meet existing demand. The EBI RDF platform has been developed to meet an increasing demand to coordinate RDF activities across the institute and provides a new entry point to querying and exploring integrated resources available at the EBI.

MOTIVATION: Advancing the search, publication and integration of bioinformatics tools and resources demands consistent machine-understandable descriptions. A comprehensive ontology allowing such descriptions is therefore required. RESULTS: EDAM is an ontology of bioinformatics operations (tool or workflow functions), types of data and identifiers, application domains and data formats. EDAM supports semantic annotation of diverse entities such as Web services, databases, programmatic libraries, standalone tools, interactive applications, data schemas, datasets and publications within bioinformatics. EDAM applies to organizing and finding suitable tools and data and to automating their integration into complex applications or workflows. It includes over 2200 defined concepts and has successfully been used for annotations and implementations. AVAILABILITY: The latest stable version of EDAM is available in OWL format from http://edamontology.org/EDAM.owl and in OBO format from http://edamontology.org/EDAM.obo. It can be viewed online at the NCBO BioPortal and the EBI Ontology Lookup Service. For documentation and license please refer to http://edamontology.org. This article describes version 1.2 available at http://edamontology.org/EDAM_1.2.owl. CONTACT: [email protected].

MOTIVATION: Describing biological sample variables with ontologies is complex due to the cross-domain nature of experiments. Ontologies provide annotation solutions; however, for cross-domain investigations, multiple ontologies are needed to represent the data. These are subject to rapid change, are often not interoperable and present complexities that are a barrier to biological resource users. RESULTS: We present the Experimental Factor Ontology, designed to meet cross-domain, application focused use cases for gene expression data. We describe our methodology and open source tools used to create the ontology. These include tools for creating ontology mappings, ontology views, detecting ontology changes and using ontologies in interfaces to enhance querying. The application of reference ontologies to data is a key problem, and this work presents guidelines on how community ontologies can be presented in an application ontology in a data-driven way. AVAILABILITY: http://www.ebi.ac.uk/efo.

Abstract Summary: The MAGE-TAB format for microarray data representation and exchange has been proposed by the microarray community to replace the more complex MAGE-ML format. We present a suite of tools to support MAGE-TAB generation and validation, conversion between existing formats for data exchange, visualization of the experiment designs encoded by MAGE-TAB documents and the mining of such documents for semantic content. Availability: Software is available from http://tab2mage.sourceforge.net/ Contact: [email protected]

When facing the emerging circumstance that the Internet and business globalization have replaced the separation that was typical of the traditional business paradigm, especially the workflow and grid environment, challenges have been made to the traditional static access control model. To solve these challenges, we present a dynamic access control prediction mechanism for service workflow base on Markov chain. We abstract the service workflow in workflow and/or grid to an ordered service sequence and through calculating the executable probability of service in OSS, we create an authorization policy based on the probability value dynamically. A simulation method of the mechanism is presented and practiced in ChinaGrid project

There has been little research into the use of hybrid neural data mining to improve robot performance or enhance their capability. This paper presents a novel neural data mining technique that analyses robot sensor data for imitation learning. Learning by imitation allows a robot to learn from observing either another robot or a human to gain skills, understand the behavior of others and create solutions to problems. We demonstrate a hybrid approach of differential ratio data mining to perform analysis on spatio-temporal robot behavioral data. The technique offers classification performance gains for recognition of robot actions by highlighting points of covariance and hence interest within the data.