This paper presents a framework to explore multi-field data of aneurysms occurring at intracranial and cardiac arteries by using statistical graphics. The rupture of an aneurysm is often a fatal scenario, whereas during treatment serious complications for the patient can occur. Whether an aneurysm ruptures or whether a treatment is successful depends on the interaction of different morphological such as wall deformation and thickness, and hemodynamic attributes like wall shear stress and pressure. Therefore, medical researchers are very interested in better understanding these relationships. However, the required analysis is a time-consuming process, where suspicious wall regions are difficult to detect due to the time-dependent behavior of the data. Our proposed visualization framework enables medical researchers to efficiently assess aneurysm risk and treatment options. This comprises a powerful set of views including 2D and 3D depictions of the aneurysm morphology as well as statistical plots of different scalar fields. Brushing and linking aids the user to identify interesting wall regions and to understand the influence of different attributes on the aneurysm's state. Moreover, a visual comparison of pre- and post-treatment as well as different treatment options is provided. Our analysis techniques are designed in collaboration with domain experts, e.g., physicians, and we provide details about the evaluation.

Intracranial aneurysms are pathologic dilations of the vessel wall, which bear the risk of rupture and of fatal consequences for the patient. Since treatment may be accompanied by severe complications as well, rupture risk assessment and thus rupture risk prediction plays an important role in clinical research. In this work, we investigate the potential of morphological features for rupture risk status classification in 100 intracranial aneurysms. We propose a pipeline for morphological feature extraction and rupture status classification with subsequent feature ranking and inspection. Our classification setup involves training separate models for each aneurysm type (sidewall or bifurcation) with multiple learning algorithms. We report on the classification performance of our pipeline and examine the predictive power of each morphological parameter towards rupture status classification. Further, we identify the most important features for the best models and study their marginal prediction.

Abstract Rupture risk assessment is a key to devise patient‐specific treatment plans of cerebral aneurysms. To understand and predict the development of aneurysms and other vascular diseases over time, both hemodynamic flow patterns and their effect on the vessel surface need to be analyzed. Flow structures close to the vessel wall often correlate directly with local changes in surface parameters, such as pressure or wall shear stress. Yet, in many existing applications, the analyses of flow and surface features are either somewhat detached from one another or only globally available. Especially for the identification of specific blood flow characteristics that cause local startling parameters on the vessel surface, like elevated pressure values, an interactive analysis tool is missing. The explorative visualization of flow data is challenging due to the complexity of the underlying data. In order to find meaningful structures in the entirety of the flow, the data has to be filtered based on the respective explorative aim. In this paper, we present a combination of visualization, filtering and interaction techniques for explorative analysis of blood flow with a focus on the relation of local surface parameters and underlying flow structures. Coherent bundles of pathlines can be interactively selected based on their relation to features of the vessel wall and further refined based on their own hemodynamic features. This allows the user to interactively select and explore flow structures locally affecting a certain region on the vessel wall and therefore to understand the cause and effect relationship between these entities. Additionally, multiple selected flow structures can be compared with respect to their quantitative parameters, such as flow speed. We confirmed the usefulness of our approach by conducting an informal interview with two expert neuroradiologists and an expert in flow simulation. In addition, we recorded several insights the neuroradiologists were able to gain with the help of our tool.

Abstract Medical visualizations are highly adapted to a specific medical application scenario. Therefore, many researchers conduct qualitative evaluations with a low number of physicians or medical experts to assess the benefits of their visualization technique. Although this type of research has advantages, it is difficult to reproduce and can be subjectively biased. This makes it problematic to quantify the benefits of a new visualization technique. Quantitative evaluation can objectify research and help bringing new visualization techniques into clinical practice. To support researchers, we present guidelines to quantitatively evaluate medical visualizations, considering specific characteristics and difficulties. We demonstrate the adaptation of these guidelines on the example of comparative aneurysm surface visualizations. We developed three visualization techniques to compare aneurysm volumes. The visualization techniques depict two similar, but not identical aneurysm surface meshes. In a user study with 34 participants and five aneurysm data sets, we assessed objective measures (accuracy and required time) and subjective ratings (suitability and likeability). The provided guidelines and presentation of different stages of the evaluation allow for an easy adaptation to other application areas of medical visualization.

Abstract The qualitative exploration of near‐wall hemodynamics in cerebral aneurysms provides important insights for risk assessment. For instance, a direct relation between complex flow patterns and aneurysm formation could be observed. Due to the high complexity of the underlying time‐dependent flow data, the exploration is challenging, in particular for medical researchers not familiar with such data. We present the AmniVis‐Explorer, a system that is designed for the preparation of a qualitative medical study. The provided features were developed in close collaboration with medical researchers involved in the study. This comprises methods for a purposeful selection of surface regions of interest and a novel approach to provide a 2D overview of flow patterns that are represented by streamlines at these regions. Furthermore, we present a specialized interface that supports binary classification of patterns and temporal exploration as well as methods for selection, highlighting and automatic 3D navigation to particular patterns. Based on eight representative datasets, we conducted informal interviews with two bord‐certified radiologists and a flow expert to evaluate the system. It was confirmed that the AmniVis‐Explorer allows for an easy selection, qualitative exploration and classification of near‐wall flow patterns that are represented by streamlines.