Computer-aided diagnosis (CAD) has become one of the hot research directions in the combination of medicine and machine learning (ML). While the characteristic of high feature number and low sample size in disease datasets makes it difficult for ML to make effective predictions. Currently, one of the most commonly used methods to address this issue is the use of heuristic algorithms for feature selection (FS). However, traditional heuristic algorithms still have certain limitations. On one hand, single-objective algorithms only focus on model's accu-racy, which always leads to a large number of redundant features remaining after FS. On the other hand, while multi-objective algorithms may result in fewer features, they often significantly reduce accuracy compared to single-objective algorithms. To solve these shortcoming, we proposes a novel FS algorithm based on harris hawk optimization (HHO) algorithm, attempting to achieve a better balance between the number of features and model's accuracy. Specifically, since the original HHO algorithm was only used for continuous numerical problems, we defines a new set of discrete operations for HHO to make it suitable for feature selection. Additionally, we introduce an aggregation function that allows the model to consider both model's accuracy and the number of features with a single objective. To mitigate the accuracy degradation caused by the aggregation function, a scale-free network was employed to improve the model's optimization capability. To comprehensively evaluate the proposed algorithm, we compare it with commonly used single-objective algorithms and multi-objective algorithms. Experimental results show that the proposed algorithm offers a better balance compared to commonly used heuristic algorithms.

Binocular vision serves as the foundation for stereo vision, providing humans with the ability to perceive the three-dimensional information of their surroundings. However, although some cortical neurons are reported with 3D information selectivity, the interconnections between binocular input and cortical neuron firing have yet to be fully established, impeding progress in our understanding of stereo information perception. In this work, we aim to address this issue by examining the causality between retinal input and selective neuron firing. We propose a general mechanism of stereo orientation and motion direction detection based solely on binocular disparity input, which is the difference in visual information between the two eyes. Our results suggest that this disparity-based mechanism is robust and can effectively complete stereo orientation and motion direction detection. Our proposed general perceiving mechanism has the potential to contribute to the resolution of the complex problem of binocular information processing and computation. Further research into this area may help to deepen our understanding of stereo vision and provide insights into the underlying neural mechanisms.

In recent years, convolutional neural networks (CNNs) have dominated the field of computer vision . Compared to traditional methods, these neural network algorithms exhibit strong biomimetic performance advantages in complex visual tasks due to their brain-like structure. However, because some necessary neural characteristics are ignored, these neural network algorithms differ greatly from the computational mechanisms of the brain. This paper starts with extracting basic visual features such as motion direction information from the brain and abstracts, generalizes and models a novel artificial visual system (AVS) for detecting object motion direction in color images based on existing relevant neurophysiological knowledge. We propose a mathematical model and quantification mechanism for each component neuron that generates motion direction selectivity in the visual system using dendritic neuron models, spiking neural network concepts and neurophysiological knowledge of retinal direction-selective ganglion cell pathways. The experiment is based on one million instances of object motion under different environments of noise-free, static and dynamic random noise, dynamic salt-and-pepper noise, dynamic Gaussion noise, and dynamic light changing. In comparison with 4 famous CNNs, LeNet-5, EfficientNetB0, ResNet18, and RegNetX-200MF, we test and verify AVS’s effectiveness, efficiency and strong generalization ability as well as other biomimetic performance advantages including high biological rationality, learning-free capability, interpretability and ease-of-use etc. AVS demonstrates that neuroscience still has important implications for guiding and promoting the development of artificial intelligence technology. Furthermore, AVS firstly provides a successful quantitative reference case study for further understanding motion direction selectivity and other primary cortical encoding characteristics in the brain.

A novel coronavirus discovered in late 2019 (COVID-19) quickly spread into a global epidemic and, thankfully, was brought under control by 2022. Because of the virus's unknown mutations and the vaccine's waning potency, forecasting is still essential for resurgence prevention and medical resource management. Computational efficiency and long-term accuracy are two bottlenecks for national-level forecasting. This study develops a novel multivariate time series forecasting model, the densely connected highly flexible dendritic neuron model (DFDNM) to predict daily and weekly positive COVID-19 cases. DFDNM's high flexibility mechanism improves its capacity to deal with nonlinear challenges. The dense introduction of shortcut connections alleviates the vanishing and exploding gradient problems, encourages feature reuse, and improves feature extraction. To deal with the rapidly growing parameters, an improved variation of the adaptive moment estimation (AdamW) algorithm is employed as the learning algorithm for the DFDNM because of its strong optimization ability. The experimental results and statistical analysis conducted across three Japanese prefectures confirm the efficacy and feasibility of the DFDNM while outperforming various state-of-the-art machine learning models. To the best of our knowledge, the proposed DFDNM is the first to restructure the dendritic neuron model's neural architecture, demonstrating promising use in multivariate time series prediction. Because of its optimal performance, the DFDNM may serve as an important reference for national and regional government decision-makers aiming to optimize pandemic prevention and medical resource management. We also verify that DFDMN is efficiently applicable not only to COVID-19 transmission prediction, but also to more general multivariate prediction tasks. It leads us to believe that it might be applied as a promising prediction model in other fields.

A single dendritic neuron model (DNM) that owns the nonlinear information processing ability of dendrites has been widely used for classification and prediction. Complex-valued neural networks that consist of a number of multiple/deep-layer McCulloch-Pitts neurons have achieved great successes so far since neural computing was utilized for signal processing. Yet no complex value representations appear in single neuron architectures. In this article, we first extend DNM from a real-value domain to a complex-valued one. Performance of complex-valued DNM (CDNM) is evaluated through a complex XOR problem, a non-minimum phase equalization problem, and a real-world wind prediction task. Also, a comparative analysis on a set of elementary transcendental functions as an activation function is implemented and preparatory experiments are carried out for determining hyperparameters. The experimental results indicate that the proposed CDNM significantly outperforms real-valued DNM, complex-valued multi-layer perceptron, and other complex-valued neuron models.

An approximate logic neural model (ALNM) is a novel single-neuron model with plastic dendritic morphology. During the training process, the model can eliminate unnecessary synapses and useless branches of dendrites. It will produce a specific dendritic structure for a particular task. The simplified structure of ALNM can be substituted by a logic circuit classifier (LCC) without losing any essential information. The LCC merely consists of the comparator and logic NOT, AND, and OR gates. Thus, it can be easily implemented in hardware. However, the architecture of ALNM affects the learning capacity, generalization capability, computing time and approximation of LCC. Thus, a Pareto-based multiobjective differential evolution (MODE) algorithm is proposed to simultaneously optimize ALNM's topology and weights. MODE can generate a concise and accurate LCC for every specific task from ALNM. To verify the effectiveness of MODE, extensive experiments are performed on eight benchmark classification problems. The statistical results demonstrate that MODE is superior to conventional learning methods, such as the backpropagation algorithm and single-objective evolutionary algorithms. In addition, compared against several commonly used classifiers, both ALNM and LCC are capable of obtaining promising and competitive classification performances on the benchmark problems. Besides, the experimental results also verify that the LCC obtains the faster classification speed than the other classifiers.

Neurons are the fundamental units of the brain and nervous system. Developing a good modeling of human neurons is very important not only to neurobiology but also to computer science and many other fields. The McCulloch and Pitts neuron model is the most widely used neuron model, but has long been criticized as being oversimplified in view of properties of real neuron and the computations they perform. On the other hand, it has become widely accepted that dendrites play a key role in the overall computation performed by a neuron. However, the modeling of the dendritic computations and the assignment of the right synapses to the right dendrite remain open problems in the field. Here, we propose a novel dendritic neural model (DNM) that mimics the essence of known nonlinear interaction among inputs to the dendrites. In the model, each input is connected to branches through a distance-dependent nonlinear synapse, and each branch performs a simple multiplication on the inputs. The soma then sums the weighted products from all branches and produces the neuron's output signal. We show that the rich nonlinear dendritic response and the powerful nonlinear neural computational capability, as well as many known neurobiological phenomena of neurons and dendrites, may be understood and explained by the DNM. Furthermore, we show that the model is capable of learning and developing an internal structure, such as the location of synapses in the dendritic branch and the type of synapses, that is appropriate for a particular task - for example, the linearly nonseparable problem, a real-world benchmark problem - Glass classification and the directional selectivity problem.

The problem of predicting the three-dimensional (3-D) structure of a protein from its one-dimensional sequence has been called the "holy grail of molecular biology", and it has become an important part of structural genomics projects. Despite the rapid developments in computer technology and computational intelligence, it remains challenging and fascinating. In this paper, to solve it we propose a multi-objective evolutionary algorithm. We decompose the protein energy function Chemistry at HARvard Macromolecular Mechanics force fields into bond and non-bond energies as the first and second objectives. Considering the effect of solvent, we innovatively adopt a solvent-accessible surface area as the third objective. We use 66 benchmark proteins to verify the proposed method and obtain better or competitive results in comparison with the existing methods. The results suggest the necessity to incorporate the effect of solvent into a multi-objective evolutionary algorithm to improve protein structure prediction in terms of accuracy and efficiency.

Almost all current spoken dialog systems treat dialog as that where a single user talks to an agent. We, on the other hand, set out to investigate a multiparty dialog system that deals with two agents and a single user. We developed a three person (one user and two agents) and a two person (one user and one agent) dialog system to consider the same dialog task, that is, “Which do you prefer, udon or ramen (Japanese noodle or Chinese noodle)?” and compared them with respect to user behavior and satisfaction. According to the results of the experiments, the three person dialog system performed better in terms of lively conversation, and user can talk with the agents more like chatting.