Registration is a fundamental task in medical image analysis which can be applied to several tasks including image segmentation, intra-operative tracking, multi-modal image alignment, and motion analysis. Popular registration tools such as ANTs and NiftyReg optimize an objective function for each pair of images from scratch which is time-consuming for large images with complicated deformation. Facilitated by the rapid progress of deep learning, learning-based approaches such as VoxelMorph have been emerging for image registration. These approaches can achieve competitive performance in a fraction of a second on advanced GPUs. In this work, we construct a neural registration framework, called NeurReg, with a hybrid loss of displacement fields and data similarity, which substantially improves the current state-of-the-art of registrations. Within the framework, we simulate various transformations by a registration simulator which generates fixed image and displacement field ground truth for training. Furthermore, we design three segmentation frameworks based on the proposed registration framework: 1) atlas-based segmentation, 2) joint learning of both segmentation and registration tasks, and 3) multi-task learning with atlas-based segmentation as an intermediate feature. Extensive experimental results validate the effectiveness of the proposed NeurReg framework based on various metrics: the endpoint error (EPE) of the predicted displacement field, mean square error (MSE), normalized local cross-correlation (NLCC), mutual information (MI), Dice coefficient, uncertainty estimation, and the interpretability of the segmentation. The proposed NeurReg improves registration accuracy with fast inference speed, which can greatly accelerate related medical image analysis tasks.

BACKGROUND: Deep learning has been recently applied to a multitude of computer vision and medical image analysis problems. Although recent research efforts have improved the state of the art, most of the methods cannot be easily accessed, compared or used by other researchers or clinicians. Even if developers publish their code and pre-trained models on the internet, integration in stand-alone applications and existing workflows is often not straightforward, especially for clinical research partners. In this paper, we propose an open-source framework to provide AI-enabled medical image analysis through the network. METHODS: TOMAAT provides a cloud environment for general medical image analysis, composed of three basic components: (i) an announcement service, maintaining a public registry of (ii) multiple distributed server nodes offering various medical image analysis solutions, and (iii) client software offering simple interfaces for users. Deployment is realized through HTTP-based communication, along with an API and wrappers for common image manipulations during pre- and post-processing. RESULTS: We demonstrate the utility and versatility of TOMAAT on several hallmark medical image analysis tasks: segmentation, diffeomorphic deformable atlas registration, landmark localization, and workflow integration. Through TOMAAT, the high hardware demands, setup and model complexity of demonstrated approaches are transparent to users, who are provided with simple client interfaces. We present example clients in three-dimensional Slicer, in the web browser, on iOS devices and in a commercially available, certified medical image analysis suite. CONCLUSION: TOMAAT enables deployment of state-of-the-art image segmentation in the cloud, fostering interaction among deep learning researchers and medical collaborators in the clinic. Currently, a public announcement service is hosted by the authors, and several ready-to-use services are registered and enlisted at http://tomaat.cloud.

Convolutional Neural Networks (CNNs) have been recently employed to solve problems from both the computer vision and medical image analysis fields. Despite their popularity, most approaches are only able to process 2D images while most medical data used in clinical practice consists of 3D volumes. In this work we propose an approach to 3D image segmentation based on a volumetric, fully convolutional, neural network. Our CNN is trained end-to-end on MRI volumes depicting prostate, and learns to predict segmentation for the whole volume at once. We introduce a novel objective function, that we optimise during training, based on Dice coefficient. In this way we can deal with situations where there is a strong imbalance between the number of foreground and background voxels. To cope with the limited number of annotated volumes available for training, we augment the data applying random non-linear transformations and histogram matching. We show in our experimental evaluation that our approach achieves good performances on challenging test data while requiring only a fraction of the processing time needed by other previous methods.

Real-time 3D Echocardiography (RT3DE) has been proven to be an accurate tool for left ventricular (LV) volume assessment. However, identification of the LV endocardium remains a challenging task, mainly because of the low tissue/blood contrast of the images combined with typical artifacts. Several semi and fully automatic algorithms have been proposed for segmenting the endocardium in RT3DE data in order to extract relevant clinical indices, but a systematic and fair comparison between such methods has so far been impossible due to the lack of a publicly available common database. Here, we introduce a standardized evaluation framework to reliably evaluate and compare the performance of the algorithms developed to segment the LV border in RT3DE. A database consisting of 45 multivendor cardiac ultrasound recordings acquired at different centers with corresponding reference measurements from three experts are made available. The algorithms from nine research groups were quantitatively evaluated and compared using the proposed online platform. The results showed that the best methods produce promising results with respect to the experts' measurements for the extraction of clinical indices, and that they offer good segmentation precision in terms of mean distance error in the context of the experts' variability range. The platform remains open for new submissions.

We propose a novel approach to online visual tracking that combines the robustness of sparse coding with the flexibility of voting-based methods. Our algorithm relies on a dictionary that is learned once and for all from a large set of training patches extracted from images unrelated to the test sequences. In this way we obtain basis functions, also known as atoms, that can be sparsely combined to reconstruct local image content. In order to adapt the generic knowledge encoded in the dictionary to the specific object being tracked, we associate a set of votes and local object appearances to each atom: this is the only information being updated during online tracking. In each frame of the sequence the object's bounding box position is retrieved through a voting strategy. Our method exhibits robustness towards occlusions, sudden local and global illumination changes as well as shape changes. We test our method on 50 standard sequences obtaining results comparable or superior to the state of the art.