Smartphones can capture diverse spatio-temporal data about an individual; including both intermittent self-report, and continuous passive data collection from onboard sensors and applications. The resulting personal data streams can support powerful inference about the user's state, behavior, well-being and environment. However making sense and acting on these multi-dimensional, heterogeneous data streams requires iterative and intensive exploration of the datasets, and development of customized analysis techniques that are appropriate for a particular health domain.