Accurate classification of sleep stages based on bio-signals is fundamental not only for automatic sleep stage annotation, but also for clinical health management and continuous sleep monitoring. Traditionally, this task relies on experienced clinicians to manually annotate data, a process that is both time-consuming and labor-intensive. In recent years, deep learning methods have shown promise in automating this task. However, three major challenges remain: (1) deep learning models typically require large-scale labeled datasets, making them less effective in real-world settings where annotated data is limited; (2) significant inter-individual variability in bio-signals often results in inconsistent model performance when applied to new subjects, limiting generalization; and (3) existing approaches often overlook the high-order relationships among bio-signals, failing to simultaneously capture signal heterogeneity and spatial-temporal dependencies. To address these issues, we propose MetaSTH-Sleep, a few-shot sleep stage classification framework based on spatial-temporal hypergraph enhanced meta-learning. Our approach enables rapid adaptation to new subjects using only a few labeled samples, while the hypergraph structure effectively models complex spatial interconnections and temporal dynamics simultaneously in EEG signals. Experimental results demonstrate that MetaSTH-Sleep achieves substantial performance improvements across diverse subjects, offering valuable insights to support clinicians in sleep stage annotation.

Metal artifacts in computed tomography (CT) images can significantly degrade image quality and impede accurate diagnosis. Supervised metal artifact reduction (MAR) methods, trained using simulated datasets, often struggle to perform well on real clinical CT images due to a substantial domain gap. Although state-of-the-art semi-supervised methods use pseudo ground-truths generated by a prior network to mitigate this issue, their reliance on a fixed prior limits both the quality and quantity of these pseudo ground-truths, introducing confirmation bias and reducing clinical applicability. To address these limitations, we propose a novel radiologist-in-the-loop self-training framework for MAR, termed RISE-MAR, which can integrate radiologists' feedback into the semi-supervised learning process, progressively improving the quality and quantity of pseudo ground-truths for enhanced generalization on real clinical CT images. For quality assurance, we introduce a clinical quality assessor model that emulates radiologist evaluations, effectively selecting high-quality pseudo ground-truths for semi-supervised training. For quantity assurance, our self-training framework iteratively generates additional high-quality pseudo ground-truths, expanding the clinical dataset and further improving model generalization. Extensive experimental results on multiple clinical datasets demonstrate the superior generalization performance of our RISE-MAR over state-of-the-art methods, advancing the development of MAR models for practical application. The source code is available at https://github.com/Masaaki-75/rise-mar.

Quick response (QR) codes are widely used in offline to online channels to transfer information from promotional materials to mobile devices. Self-service medical equipment can record the data of each test, so the use of QR codes can realize the data exchange between patients and doctors, medical institutions, and self-service medical equipment, and create a medical information platform for health files. However, since anyone can easily read the information in the QR code, it is not conducive to the protection of patient privacy. Therefore, we propose a QR code encryption and decryption model based on robust digital watermarking. We implement digital watermarking through the generative adversarial networks and increase the robustness of the watermark by adding noise to the model. At the same time, we encrypt and decrypt the QR code information through advanced encryption standards. Experimental results show that the proposed method can well protect the privacy of patients without affecting the data acquisition by patients and doctors.

When using magnetic resonance tomography (MRT) for imaging 2-D or 3-D water-bearing structures in a subsurface, the transmitting frequency must be the same as the Larmor frequency. Due to the inhomogeneity and noise interference in a geomagnetic field, it is difficult to determine the precise Larmor frequency using a magnetometer, resulting in unknown frequency offsets and inaccurate estimations of water content and relaxation time ($T_{2}^{*}$). To solve the 2-D MRT imaging problem in the case of an unknown frequency offset, a frequency cycling method is proposed in this article. This method takes the estimated Larmor frequency as the center, uses two frequencies with the same offset for transmitting, then combines the acquired MRT signals to obtain frequency-cycled data, and finally uses the off-resonance kernel function for inversion. Based on MRT forward modeling and QT inversion, we conduct synthetic data experiments on a complex model with three water-bearing structures and test the 2-D imaging results of the frequency-cycled data. The results show that the water content and$T_{2}^{*}$distribution obtained by the inversion of the frequency-cycled data can accurately reflect the water-bearing structure, which is better than the results of the assumed on-resonance case. In addition, the phase correction method presented in this article significantly improves the accuracy of 2-D MRT estimated aquifer properties under low resistivity conditions. Finally, the validity and accuracy of the frequency cycling method are verified by comparing the inversion results of the data with known drilling data collected in field measurements.

Lung cancer has been the leading death cause in modern society. Early detection of pulmonary nodules can significantly improve the survival rate of lung cancer. In this paper, we propose a novel pulmonary nodule detection framework and a novel 3D dense attention module (DAM) which can efficiently exploit the abundant 3D spatial features. The attention module, which integrates the improved dense block and the conv attention block, focuses on three dimensions, plane attention, depth attention, and channel attention. And the whole framework consists of two phases: Nodule Candidate Generation (NCG) and False Positive Reduction (FPR). In NCG phase, we construct a detection network based on DAM. Due to the wide distribution of the nodule diameters, we propose a 3D Feature Pyramid Network (3DFPN) to better handle the scale-varying problem. In FPR phase, we design a 3D DCNN to erase the false positives. Sliding-window based data augment methods are adopted to deal with the unbalance problem of the data. Comprehensive experiments show that our scheme outperforms the existing methods.

Flow-based video frame interpolation approaches typically adopt forward or backward warping to approximate the intermediate frames. And a synthesis network is used to refine the interpolation results. Optical flows indicate motion between two input frames, but both forward and backward warping only utilize the first frame. In this work, we propose bilateral warping to make full use of optical flows. Specifically, the proposed bilateral warping yields intermediate candidates from not only the first frame but also the second frame. Our model first applies bilateral warping on the input frames and contextual features. Then, we add skip connections from the input frames and contextual features to the synthesis network. Finally, the synthesis network generates the interpolation results by integrating the original and warped representations. The experimental results on a wide variety of datasets demonstrate the superiority of the proposed approach over the state-of-the-art video frame interpolation methods.

SUMMARY: Cancer Gene and Pathway Explorer (CGPE) is developed to guide biological and clinical researchers, especially those with limited informatics and programming skills, performing preliminary cancer-related biomedical research using transcriptional data and publications. CGPE enables three user-friendly online analytical and visualization modules without requiring any local deployment. The GenePub HotIndex applies natural language processing, statistics and association discovery to provide analytical results on gene-specific PubMed publications, including gene-specific research trends, cancer types correlations, top-related genes and the WordCloud of publication profiles. The OnlineGSEA enables Gene Set Enrichment Analysis (GSEA) and results visualizations through an easy-to-follow interface for public or in-house transcriptional datasets, integrating the GSEA algorithm and preprocessed public TCGA and GEO datasets. The preprocessed datasets ensure gene sets analysis with appropriate pathway alternation and gene signatures. The CellLine Search presents evidence-based guidance for cell line selections with combined information on cell line dependency, gene expressions and pathway activity maps, which are valuable knowledge to have before conducting gene-related experiments. In a nutshell, the CGPE webserver provides a user-friendly, visual, intuitive and informative bioinformatics tool that allows biomedical researchers to perform efficient analyses and preliminary studies on in-house and publicly available bioinformatics data. AVAILABILITY AND IMPLEMENTATION: The webserver is freely available online at https://cgpe.soic.iupui.edu. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

With the rapid development of Internet, the issue of cyber security has increasingly gained more attention. An intrusion Detection System (IDS) is an effective technique to defend cyber-attacks and reduce security losses. However, the challenge of IDS lies in the diversity of cyber-attackers and the frequently-changing data requiring a flexible and efficient solution. To address this problem, machine learning approaches are being applied in the IDS field. In this paper, we propose an efficient scalable neural-network-based hybrid IDS framework with the combination of Host-level IDS (HIDS) and Network-level IDS (NIDS). We applied the autoencoders (AE) to NIDS and designed HIDS using word embedding and convolutional neural network. To evaluate the IDS, many experiments are performed on the public datasets NSL-KDD and ADFA. It can detect many attacks and reduce the security risk with high efficiency and excellent scalability.

In image detection, it is often necessary to detect the sizes of foreign bodies in binary images. A new method to detect particle sizes of objects is proposed in this paper based on binary image analysis. A difference sum template is first used to extract edge of an object, a half-8-connected domain algorithm is then employed to obtain the coordinates set that corresponds to each object, and finally evaluates the particle size of every object through rectangular segmentation. In comparison with the method of geometrical principal axis and the MER method, the algorithm can obtain particle sizes of objects in binary image more rapidly and more accurately.