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Linda Krause

dblp:138/5703 · DBLP profile ↗
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1ranked-venue papers
0as first author
0since 2021 · last 2013
0000-0002-8490-5717ORCID · reported

Domains — the database's venue-derived domains; a paper can count in several

Applied, interdisciplinary, general and emerging computing · 1

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
1 paper
Bioinformatics and computational biology · 100%

Topics — the 2 heaviest of 2, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Bioinformatics and computational biology
population genetics
0.212013
An alignment-free test for recombination · Bioinform. 2013
Bioinformatics and computational biology › molecular evolution
recombination detection
0.212013
An alignment-free test for recombination · Bioinform. 2013

Methods — techniques the papers use, named apart from their topics

match length distribution · 0.2enhanced suffix array · 0.2
YearPublicationVenuePosition
2013 An alignment-free test for recombination
abstract
MOTIVATION: Why recombination? is one of the central questions in biology. This has led to a host of methods for quantifying recombination from sequence data. These methods are usually based on aligned DNA sequences. Here, we propose an efficient alignment-free alternative. RESULTS: Our method is based on the distribution of match lengths, which we look up using enhanced suffix arrays. By eliminating the alignment step, the test becomes fast enough for application to whole bacterial genomes. Using simulations we show that our test has similar power as established tests when applied to long pairs of sequences. When applied to 58 genomes of Escherichia coli, we pick up the strongest recombination signal from a 125 kb horizontal gene transfer engineered 20 years ago. AVAILABILITY AND IMPLEMENTATION: We have implemented our method in the command-line program rush. Its C sources and documentation are available under the GNU General Public License from http://guanine.evolbio.mpg.de/rush/.
Bernhard Haubold, Linda Krause, Thomas Horn, Peter Pfaffelhuber
Bioinform.2