Demo Data from EDBT 2026 / reviewers in the wild / expert
Johannes Engelken
dblp:141/5532
· DBLP profile ↗
1ranked-venue papers
0as first author
0since 2021 · last 2015
—ORCID · none
Domains — the database's venue-derived domains; a paper can count in several
Applied, interdisciplinary, general and emerging computing · 1
Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.
| Interdisciplinary, comprehensive, and emerging computing
1 paper |
Bioinformatics and computational biology · 100% |
Topics — the 2 heaviest of 2, each with the papers that count most for it
| Topic | Weight | Papers | Last | Evidence papers |
|---|---|---|---|---|
Bioinformatics and computational biology
population genetics |
0.2 | 1 | 2015 | Hierarchical boosting: a machine-learning framework to detect and classify hard selective sweeps in human populations · Bioinform. 2015 |
Bioinformatics and computational biology › population genetics › selection detection
selective sweep detection |
0.2 | 1 | 2015 | Hierarchical boosting: a machine-learning framework to detect and classify hard selective sweeps in human populations · Bioinform. 2015 |
Methods — techniques the papers use, named apart from their topics
machine learning classification · 0.2hierarchical boosting · 0.2
| Year | Publication | Venue | Position |
|---|---|---|---|
| 2015 | Hierarchical boosting: a machine-learning framework to detect and classify hard selective sweeps in human populationsabstractMOTIVATION: Detecting positive selection in genomic regions is a recurrent topic in natural population genetic studies. However, there is little consistency among the regions detected in several genome-wide scans using different tests and/or populations. Furthermore, few methods address the challenge of classifying selective events according to specific features such as age, intensity or state (completeness). RESULTS: We have developed a machine-learning classification framework that exploits the combined ability of some selection tests to uncover different polymorphism features expected under the hard sweep model, while controlling for population-specific demography. As a result, we achieve high sensitivity toward hard selective sweeps while adding insights about their completeness (whether a selected variant is fixed or not) and age of onset. Our method also determines the relevance of the individual methods implemented so far to detect positive selection under specific selective scenarios. We calibrated and applied the method to three reference human populations from The 1000 Genome Project to generate a genome-wide classification map of hard selective sweeps. This study improves detection of selective sweep by overcoming the classical selection versus no-selection classification strategy, and offers an explanation to the lack of consistency observed among selection tests when applied to real data. Very few signals were observed in the African population studied, while our method presents higher sensitivity in this population demography. AVAILABILITY AND IMPLEMENTATION: The genome-wide results for three human populations from The 1000 Genomes Project and an R-package implementing the 'Hierarchical Boosting' framework are available at http://hsb.upf.edu/. Marc Pybus, Pierre Luisi, Giovanni Marco Dall'Olio, Manu Uzkudun, Hafid Laayouni, Jaume Bertranpetit, Johannes Engelken |
Bioinform. | 7 |