Large Language Models (LLMs) have gained significant attention for their exceptional performance across various domains. Despite their advancements, concerns persist regarding their implicit bias, which often leads to negative social impacts. Therefore, it is essential to identify the implicit bias in LLMs and investigate the potential threat posed by it. Our study focused on a specific type of implicit bias, termed the ''Yes-No'' implicit bias, which refers to LLMs' inherent tendency to favor ''Yes'' or ''No'' responses to a single instruction. By comparing the probability of LLMs generating a series of ''Yes'' versus ''No'' responses, we observed different inherent response tendencies exhibited by LLMs when faced with different instructions. To further investigate the impact of such bias, we developed an attack method called Implicit Bias In-Context Manipulation, attempting to manipulate LLMs' behavior. Specifically, we explored whether the ''Yes'' implicit bias could manipulate ''No'' responses into ''Yes'' in LLMs' responses to malicious instructions, leading to harmful outputs. Our findings revealed that the ''Yes'' implicit bias brings a significant security threat, comparable to that of carefully designed attack methods. Moreover, we offered a comprehensive analysis from multiple perspectives to deepen the understanding of this security threat, emphasizing the need for ongoing improvement in LLMs' security.

Molecule discovery serves as a cornerstone in numerous scientific domains, fueling the development of new materials and innovative drug designs. Recent developments of in-silico molecule discovery have highlighted the promising results of cross-modal techniques, which bridge molecular structures with their descriptive annotations. However, these cross-modal methods frequently encounter the issue of data scarcity, hampering their performance and application. In this paper, we address the low-resource challenge by utilizing artificially-real data generated by Large Language Models (LLMs). We first introduce a retrieval-based prompting strategy to construct high-quality pseudo data, then explore the optimal method to effectively leverage this pseudo data. Experiments show that using pseudo data for domain adaptation outperforms all existing methods, while also requiring a smaller model scale, reduced data size and lower training cost, highlighting its efficiency. Furthermore, our method shows a sustained improvement as the volume of pseudo data increases, revealing the great potential of pseudo data in advancing low-resource cross-modal molecule discovery.

Large Language Models (LLMs) are increasingly deployed in various applications. As their usage grows, concerns regarding their safety are rising, especially in maintaining harmless responses when faced with malicious instructions. Many defense strategies have been developed to enhance the safety of LLMs. However, our research finds that existing defense strategies lead LLMs to predominantly adopt a rejection-oriented stance, thereby diminishing the usability of their responses to benign instructions. To solve this problem, we introduce the MoGU framework, designed to enhance LLMs' safety while preserving their usability. Our MoGU framework transforms the base LLM into two variants: the usable LLM and the safe LLM, and further employs dynamic routing to balance their contribution. When encountering malicious instructions, the router will assign a higher weight to the safe LLM to ensure that responses are harmless. Conversely, for benign instructions, the router prioritizes the usable LLM, facilitating usable and helpful responses. On various open-sourced LLMs, we compare multiple defense strategies to verify the superiority of our MoGU framework. Besides, our analysis provides key insights into the effectiveness of MoGU and verifies that our designed routing mechanism can effectively balance the contribution of each variant by assigning weights. Our work released the safer Llama2, Vicuna, Falcon, Dolphin, and Baichuan2.