Web page tampering detection is crucial in web threat perception. Current methods rely on monitoring historical changes of web pages to identify anomalies. These approaches often struggle to effectively distinguish between tampering and benign changes, especially in the presence of numerous dynamic pages. Furthermore, the increasing complexity of website structures places more resource demands on tampering monitoring and makes some malicious alterations more covert and challenging to detect. We propose a web page tampering detection based on pretraining with dynamic temporal graphs. The core of the method involves constructing a website temporal graph model based on evolutionary information, and enhances the graph feature perturbations to expose concealed tampering behaviors. Specifically, the framework's autoencoder is composed of enhanced DySAT, enabling it to handle dynamic data. We introduce DySAT, bolstered with GATv2, to capture dynamic attention. Additionally, we design a temporal masking mechanism and prediction error to improve the effectiveness of generative self-supervised learning in temporal graph pretraining. Experimental results on Webpage Tampering Dataset (WPT-Dataset) demonstrate that our method outperforms other comparative approaches in terms of both detection efficacy and stability. Furthermore, the research findings on the anomaly detector and model performance provide direction for the practical application of our method.

Innate resistance to anti-PD-1 immunotherapy remains a major clinical challenge in metastatic melanoma, with the underlying molecular networks being poorly understood. To address this, we constructed a dynamic Probabilistic Boolean Network model using transcriptomic data from patient tumor biopsies to elucidate the regulatory logic governing therapy response. We then employed a reinforcement learning agent to systematically discover optimal, multi-step therapeutic interventions and used explainable artificial intelligence to mechanistically interpret the agent's control policy. The analysis revealed that a precisely timed, 4-step temporary inhibition of the lysyl oxidase like 2 protein (LOXL2) was the most effective strategy. Our explainable analysis showed that this “hit-and-run” intervention is sufficient to erase the molecular signature driving resistance, allowing the network to self-correct without requiring sustained intervention. This study presents a novel, time-dependent therapeutic hypothesis for overcoming immunotherapy resistance and provides a powerful computational framework for identifying non-obvious intervention protocols in complex biological systems.

Abstract Achieving high‐performance in multi‐object tracking algorithms heavily relies on modelling spatial‐temporal relationships during the data association stage. Mainstream approaches encompass rule‐based and deep learning‐based methods for spatial‐temporal relationship modelling. While the former relies on physical motion laws, offering wider applicability but yielding suboptimal results for complex object movements, the latter, though achieving high‐performance, lacks interpretability and involves complex module designs. This work aims to simplify deep learning‐based spatial‐temporal relationship models and introduce interpretability into features for data association. Specifically, a lightweight single‐layer transformer encoder is utilised to model spatial‐temporal relationships. To make features more interpretative, two contrastive regularisation losses based on representation alignment are proposed, derived from spatial‐temporal consistency rules. By applying weighted summation to affinity matrices, the aligned features can seamlessly integrate into the data association stage of the original tracking workflow. Experimental results showcase that our model enhances the majority of existing tracking networks' performance without excessive complexity, with minimal increase in training overhead and nearly negligible computational and storage costs.

Graph neural networks have been shown to have characteristics that make them susceptible to backdoor attacks, and many recent works have proposed feasible graph backdoor attack methods. However, existing graph backdoor attack methods only target one-to-one attack types and lack graph backdoor attack methods that can address one-to-many attack requirements. This paper is the first research work on one-to-many type graph backdoor attacks and proposes the backdoor attack method MLGB, which can achieve multi-target label attacks for GNN node classification tasks. We designed encoding mechanisms to allow MLGB to customize triggers for different target labels and ensure differentiation between triggers for different target labels through loss functions. Additionally, we designed an innovative poisoned node selection method to improve the efficiency of MLGB’s attacks further. Extensive experiments were conducted to validate MLGB’s effectiveness across multiple datasets and model architectures, demonstrating its robustness against graph backdoor attack defense mechanisms. Furthermore, ablation experiments and explainability analyses were conducted to provide deeper insights into MLGB. Our work reveals that graph neural networks are also vulnerable to one-to-many type backdoor attacks, which is important for practitioners to understand model risks comprehensively.

This paper targets unsupervised skeleton-based action representation learning and proposes a new Hierarchical Contrast (HiCo) framework. Different from the existing contrastive-based solutions that typically represent an input skeleton sequence into instance-level features and perform contrast holistically, our proposed HiCo represents the input into multiple-level features and performs contrast in a hierarchical manner. Specifically, given a human skeleton sequence, we represent it into multiple feature vectors of different granularities from both temporal and spatial domains via sequence-to-sequence (S2S) encoders and unified downsampling modules. Besides, the hierarchical contrast is conducted in terms of four levels: instance level, domain level, clip level, and part level. Moreover, HiCo is orthogonal to the S2S encoder, which allows us to flexibly embrace state-of-the-art S2S encoders. Extensive experiments on four datasets, i.e., NTU-60, NTU-120, PKU-I and PKU-II, show that HiCo achieves a new state-of-the-art for unsupervised skeleton-based action representation learning in two downstream tasks including action recognition and retrieval, and its learned action representation is of good transferability. Besides, we also show that our framework is effective for semi-supervised skeleton-based action recognition. Our code is available at https://github.com/HuiGuanLab/HiCo.

Web attack payload identification is a significant part of the Web defense system. The current Web attack payload identification usually combines natural language processing and deep learning to automatically build a detection model to intercept malicious payloads. However, these detection methods ignore the bidirectional association between fields and is prone to the payload dilution problem for long strings. In addition, the weak interpretability of deep learning models makes it difficult for researchers to solve the problem of model pollution and adjust the model according to the prediction logic. Therefore, this paper proposes a new Web attack payload identification method based on Graph Convolutional Network (GCN), which can effectively extract Web payload features and help model interpretability analysis. The core of this method is to transform the text feature problem into a graph feature extraction problem and to understand the structure and content of the Web payload from the graph perspective. The method performs node embedding on the Web payload graph through GCN, then converts the embedding vector into a graph feature vector through a feature fusion method. The node ablation method is used to analyze malicious payloads' interpretability and calculate the predicted impact rate of nodes inside the graph structure. The experiments on the CSIC 2010 v2 HTTP dataset show that the method proposed in this paper has high accuracy for identifying Web attack payloads, and the node embedding of the Relational Graph Convolutional Network (RGCN) method is more suitable for identifying Web attack payloads than other GCN methods. The research results of the paper show that the model interpretability analysis based on the Web payload graph is reasonable and can effectively assist researchers in adjusting the model and preventing the problem of model pollution.