Conversational search addresses users’ information needs through multi-turn and context-aware interactions. Given that user queries are often ambiguous, the use of clarifying questions can effectively reduce uncertainty and enable a mixed-initiative conversational system. However, current datasets for clarifying questions remain limited in the following three aspects: (1) underrepresented multi-turn conversational data, (2) limited diversity, and (3) heavily reliance on crowdsourcing, thereby suffering from limitations such as high annotation cost. To address these issues, we propose a large language model (LLM)-based three-stage framework that relies on an existing community question answering dataset. It encompasses: (1) extracting essential information from the initial user query with the relevant contextual information, (2) generating clarifying questions paired with corresponding answers, and (3) refining conversations to ensure coherence and a natural conversational flow. We assess our multi-stage method against a baseline that directly prompts LLMs to generate conversations in a single-step process, evaluating on an answer retrieval task using recall, precision, normalized discounted cumulative gain and mean average precision. Results show that our three-stage generation approach consistently outperforms the baseline particularly in recall, while also achieving competitive results across other metrics. Human and automatic evaluations further indicate the high quality of generated conversations and fine-tuning on them improves retrieval performance, highlighting the pipeline’s potential.

The permission mechanism in Android imposes additional requirements on app developers, since developers have to learn not only the APIs to be used, but also the permissions to be declared. Recommending permissions for apps becomes necessary and meaningful to help developers determine suitable permissions to be declared in apps. Previous studies suffer from the cold-start problem and do not consider the fact that categories of APIs invoked by apps may influence permissions required by apps, since APIs with similar usage may request same permissions. To address these issues, this paper proposes a Category aware Non-negative Matrix Factorization (CNMF) framework to recommend app permissions. The framework firstly calculates semantic similarities among APIs based on word embeddings and clusters similar APIs into the same category, and then computes the probabilities of apps using APIs in each category and integrates the app-category information into the non-negative matrix factorization. Experimental results on a real-world dataset show that our framework can achieve better performance than the state-of-the-art approaches.

Stream join is one of the key operations for real-time stream data query and calculation. In light of changeable velocity of stream data, traditional static stream join methods are not so adaptive that stream data computing performance will be affected. Based on the large quantity and constantly changing velocity of stream data, by considering traditional stream join algorithm, this paper proposes an optimized algorithm for variable update cycle stream based on time window (VC-TWJoin, Variable Cycle Time Window Join). For unsteady stream calculated in stream join, the optimal update cycle will be calculated to reduce the response time of stream join and improve join efficiency and real-time capability. Both theoretical analysis and experiments demonstrate that the algorithm is better than traditional join algorithms in terms of real-time capability, join response time and throughput.

BACKGROUND: Diabetes mellitus of type 2 (T2D), also known as noninsulin-dependent diabetes mellitus (NIDDM) or adult-onset diabetes, is a common disease. It is estimated that more than 300 million people worldwide suffer from T2D. In this study, we investigated the T2D, pre-diabetic and healthy human (no diabetes) bloodstream samples using genomic, genealogical, and phonemic information. We identified differentially expressed genes and pathways. The study has provided deeper insights into the development of T2D, and provided useful information for further effective prevention and treatment of the disease. RESULTS: A total of 142 bloodstream samples were collected, including 47 healthy humans, 22 pre-diabetic and 73 T2D patients. Whole genome scale gene expression profiles were obtained using the Agilent Oligo chips that contain over 20,000 human genes. We identified 79 significantly differentially expressed genes that have fold change ≥ 2. We mapped those genes and pinpointed locations of those genes on human chromosomes. Amongst them, 3 genes were not mapped well on the human genome, but the rest of 76 differentially expressed genes were well mapped on the human genome. We found that most abundant differentially expressed genes are on chromosome one, which contains 9 of those genes, followed by chromosome two that contains 7 of the 76 differentially expressed genes. We performed gene ontology (GO) functional analysis of those 79 differentially expressed genes and found that genes involve in the regulation of cell proliferation were among most common pathways related to T2D. The expression of the 79 genes was combined with clinical information that includes age, sex, and race to construct an optimal discriminant model. The overall performance of the model reached 95.1% accuracy, with 91.5% accuracy on identifying healthy humans, 100% accuracy on pre-diabetic patients and 95.9% accuract on T2D patients. The higher performance on identifying pre-diabetic patients was resulted from more significant changes of gene expressions among this particular group of humans, which implicated that patients were having profound genetic changes towards disease development. CONCLUSION: Differentially expressed genes were distributed across chromosomes, and are more abundant on chromosomes 1 and 2 than the rest of the human genome. We found that regulation of cell proliferation actually plays an important role in the T2D disease development. The predictive model developed in this study has utilized the 79 significant genes in combination with age, sex, and racial information to distinguish pre-diabetic, T2D, and healthy humans. The study not only has provided deeper understanding of the disease molecular mechanisms but also useful information for pathway analysis and effective drug target identification.