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Sayan Ghosal

dblp:158/6658 · DBLP profile ↗
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4ranked-venue papers
4as first author
2since 2021 · last 2024
0000-0002-7525-713XORCID · corroborated

Domains — the database's venue-derived domains; a paper can count in several

Artificial intelligence and machine learning · 2 · 2 first-author · 1 since 2021Applied, interdisciplinary, general and emerging computing · 2 · 2 first-author · 1 since 2021Graphics, computer vision, multimedia, augmented reality and games · 1 · 1 first-author

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
2 papers
Bioinformatics and computational biology · 93% Medical and health informatics · 7%
Artificial intelligence
1 paper
Graph learning · 100%

Topics — the 4 heaviest of 5, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Bioinformatics and computational biology › statistical genetics › fine-mapping
causal variant identification
0.812024
BEATRICE: Bayesian fine-mapping from summary data using deep variational inference · Bioinform. 2024
Bioinformatics and computational biology › statistical genetics
fine-mapping
0.812024
BEATRICE: Bayesian fine-mapping from summary data using deep variational inference · Bioinform. 2024
Bioinformatics and computational biology
statistical genetics
0.812024
BEATRICE: Bayesian fine-mapping from summary data using deep variational inference · Bioinform. 2024
Machine learning › Graph learning › graph neural network
graph convolutional network
0.612022
A Biologically Interpretable Graph Convolutional Network to Link Genetic Risk Pathways and Imaging Phenotypes of Disease · ICLR 2022

Methods — techniques the papers use, named apart from their topics

interpretability · 1.1graph convolutional network · 1.1variational inference · 0.8hierarchical bayesian model · 0.8deep neural network · 0.8
YearPublicationVenuePosition
2024 BEATRICE: Bayesian fine-mapping from summary data using deep variational inference
abstract
MOTIVATION: We introduce a novel framework BEATRICE to identify putative causal variants from GWAS statistics. Identifying causal variants is challenging due to their sparsity and high correlation in the nearby regions. To account for these challenges, we rely on a hierarchical Bayesian model that imposes a binary concrete prior on the set of causal variants. We derive a variational algorithm for this fine-mapping problem by minimizing the KL divergence between an approximate density and the posterior probability distribution of the causal configurations. Correspondingly, we use a deep neural network as an inference machine to estimate the parameters of our proposal distribution. Our stochastic optimization procedure allows us to sample from the space of causal configurations, which we use to compute the posterior inclusion probabilities and determine credible sets for each causal variant. We conduct a detailed simulation study to quantify the performance of our framework against two state-of-the-art baseline methods across different numbers of causal variants and noise paradigms, as defined by the relative genetic contributions of causal and noncausal variants. RESULTS: We demonstrate that BEATRICE achieves uniformly better coverage with comparable power and set sizes, and that the performance gain increases with the number of causal variants. We also show the efficacy BEATRICE in finding causal variants from the GWAS study of Alzheimer's disease. In comparison to the baselines, only BEATRICE can successfully find the APOE ϵ2 allele, a commonly associated variant of Alzheimer's. AVAILABILITY AND IMPLEMENTATION: BEATRICE is available for download at https://github.com/sayangsep/Beatrice-Finemapping.
Sayan Ghosal, Michael C. Schatz, Archana Venkataraman
Bioinform.1
2022 A Biologically Interpretable Graph Convolutional Network to Link Genetic Risk Pathways and Imaging Phenotypes of Disease
Sayan Ghosal, Giulio Pergola, Aaron L. Goldman, William Ulrich, Daniel R. Weinberger, Archana Venkataraman
ICLR1
2019 Bridging Imaging, Genetics, and Diagnosis in a Coupled Low-Dimensional Framework
Sayan Ghosal, Aaron L. Goldman, William Ulrich, Karen Faith Berman, Daniel R. Weinberger, Venkata S. Mattay, Archana Venkataraman
MICCAI (4)1
2017 Deep deformable registration: Enhancing accuracy by fully convolutional neural net
Sayan Ghosal, Nilanjan Ray
Pattern Recognit. Lett.1