The multi-lead electrocardiogram (ECG) stands as a cornerstone of cardiac diagnosis. Recent strides in electrocardiogram self-supervised learning (eSSL) have brightened prospects for enhancing representation learning without relying on high-quality annotations. Yet earlier eSSL methods suffer a key limitation: they focus on consistent patterns across leads and beats, overlooking the inherent differences in heartbeats rooted in cardiac conduction processes, while subtle but significant variations carry unique physiological signatures. Moreover, representation learning for ECG analysis should align with ECG diagnostic guidelines, which progress from individual heartbeats to single leads and ultimately to lead combinations. This sequential logic, however, is often neglected when applying pre-trained models to downstream tasks. To address these gaps, we propose CLEAR-HUG, a two-stage framework designed to capture subtle variations in cardiac conduction across leads while adhering to ECG diagnostic guidelines. In the first stage, we introduce an eSSL model termed Conduction-LEAd Reconstructor (CLEAR), which captures both specific variations and general commonalities across heartbeats. Treating each heartbeat as a distinct entity, CLEAR employs a simple yet effective sparse attention mechanism to reconstruct signals without interference from other heartbeats. In the second stage, we implement a Hierarchical lead-Unified Group head (HUG) for disease diagnosis, mirroring clinical workflow. Experimental results across six tasks show a 6.84% improvement, validating the effectiveness of CLEAR-HUG. This highlights its ability to enhance representations of cardiac conduction and align patterns with expert diagnostic guidelines.

Positron Emission Tomography (PET) is a powerful molecular imaging tool that plays a crucial role in modern medical diagnostics by visualizing radio-tracer distribution to reveal physiological processes. Accurate organ segmentation from PET images is essential for comprehensive multi-systemic analysis of interactions between different organs and pathologies. Existing segmentation methods are limited by insufficient annotation data and varying levels of annotation, resulting in weak generalization ability and difficulty in clinical application. Recent developments in segmentation foundation models have shown superior versatility across diverse segmentation tasks. Despite the efforts of medical adaptations, these works primarily focus on structural medical images with detailed physiological structural information and exhibit limited generalization performance on molecular PET imaging. In this paper, we collect and construct PETS-5k, the largest PET segmentation dataset to date, comprising 5,731 three-dimensional whole-body PET images and encompassing over 1.3M 2D images. Based on the established dataset, we develop SegAnyPET, a modality-specific 3D foundation model for universal promptable segmentation from PET images. To issue the challenge of discrepant annotation quality, we adopt a cross prompting confident learning (CPCL) strategy with an uncertainty-guided self-rectification process to robustly learn segmentation from high-quality labeled data and low-quality noisy labeled data for promptable segmentation. Experimental results demonstrate that SegAnyPET can segment seen and unseen target organs using only one or a few prompt points, outperforming state-of-the-art foundation models and task-specific fully supervised models with higher accuracy and strong generalization ability for universal segmentation.

The advent of single-cell Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq) offers an innovative perspective for deciphering regulatory mechanisms by assembling a vast repository of single-cell chromatin accessibility data. While foundation models have achieved significant success in single-cell transcriptomics, there is currently no foundation model for scATAC-seq that supports zero-shot high-quality cell identification and comprehensive multi-omics analysis simultaneously. Key challenges lie in the high dimensionality and sparsity of scATAC-seq data, as well as the lack of a standardized schema for representing open chromatin regions (OCRs). Here, we present ChromFound, a foundation model tailored for scATAC-seq. ChromFound utilizes a hybrid architecture and genome-aware tokenization to effectively capture genome-wide long contexts and regulatory signals from dynamic chromatin landscapes. Pretrained on 1.97 million cells from 30 tissues and 6 disease conditions, ChromFound demonstrates broad applicability across 6 diverse tasks. Notably, it achieves robust zero-shot performance in generating universal cell representations and exhibits excellent transferability in cell type annotation and cross-omics prediction. By uncovering enhancer-gene links undetected by existing computational methods, ChromFound offers a promising framework for understanding disease risk variants in the noncoding genome. The implementation of ChromFound is available via https://github.com/JohnsonKlose/ChromFound.

The generalization ability of deep learning has been extensively studied in supervised settings, yet it remains less explored in unsupervised scenarios. Recently, the Unsupervised Domain Generalization (UDG) task has been proposed to enhance the generalization of models trained with prevalent unsupervised learning techniques, such as Self-Supervised Learning (SSL). UDG confronts the challenge of distinguishing semantics from variations without category labels. Although some recent methods have employed domain labels to tackle this issue, such domain labels are often unavailable in real-world contexts. In this paper, we address these limitations by formalizing UDG as the task of learning a Minimal Sufficient Semantic Representation: a representation that (i) preserves all semantic information shared across augmented views (sufficiency), and (ii) maximally removes information irrelevant to semantics (minimality). We theoretically ground these objectives from the perspective of information theory, demonstrating that optimizing representations to achieve sufficiency and minimality directly reduces out-of-distribution risk. Practically, we implement this optimization through Minimal-Sufficient UDG (MS-UDG), a learnable model by integrating (a) an InfoNCE-based objective to achieve sufficiency; (b) two complementary components to promote minimality: a novel semantic-variation disentanglement loss and a reconstruction-based mechanism for capturing adequate variation. Empirically, MS-UDG sets a new state-of-the-art on popular unsupervised domain-generalization benchmarks, consistently outperforming existing SSL and UDG methods, without category or domain labels during representation learning.

The user base of short video apps has experienced unprecedented growth in recent years, resulting in a significant demand for video content analysis. In particular, text-video retrieval, which aims to find the top matching videos given text descriptions from a vast video corpus, is an essential function, the primary challenge of which is to bridge the modality gap. Nevertheless, most existing approaches treat texts merely as discrete tokens and neglect their syntax structures. Moreover, the abundant spatial and temporal clues in videos are often underutilized due to the lack of interaction with text. To address these issues, we argue that using texts as guidance to focus on relevant temporal frames and spatial regions within videos is beneficial. In this paper, we propose a novel Syntax-Hierarchy-Enhanced text-video retrieval method (SHE-Net) that exploits the inherent semantic and syntax hierarchy of texts to bridge the modality gap from two perspectives. First, to facilitate a more fine-grained integration of visual content, we employ the text syntax hierarchy, which reveals the grammatical structure of text descriptions, to guide the visual representations. Second, to further enhance the multi-modal interaction and alignment, we also utilize the syntax hierarchy to guide the similarity calculation. We evaluated our method on four public text-video retrieval datasets of MSR-VTT, MSVD, DiDeMo, and ActivityNet. The experimental results and ablation studies confirm the advantages of our proposed method.

Video copy localization aims to precisely localize all the copied segments within a pair of untrimmed videos in video retrieval applications. Previous methods typically start from frame-to-frame similarity matrix generated by cosine similarity between frame-level features of the input video pair, and then detect and refine the boundaries of copied segments on similarity matrix under temporal constraints. In this paper, we propose TransVCL: an attention-enhanced video copy localization network, which is optimized directly from initial frame-level features and trained end-to-end with three main components: a customized Transformer for feature enhancement, a correlation and softmax layer for similarity matrix generation, and a temporal alignment module for copied segments localization. In contrast to previous methods demanding the handcrafted similarity matrix, TransVCL incorporates long-range temporal information between feature sequence pair using self- and cross- attention layers. With the joint design and optimization of three components, the similarity matrix can be learned to present more discriminative copied patterns, leading to significant improvements over previous methods on segment-level labeled datasets (VCSL and VCDB). Besides the state-of-the-art performance in fully supervised setting, the attention architecture facilitates TransVCL to further exploit unlabeled or simply video-level labeled data. Additional experiments of supplementing video-level labeled datasets including SVD and FIVR reveal the high flexibility of TransVCL from full supervision to semi-supervision (with or without video-level annotation). Code is publicly available at https://github.com/transvcl/TransVCL.

Image retrieval plays an important role in the Internet world. Usually, the core parts of mainstream visual retrieval systems include an online service of the embedding model and a large-scale vector database. For traditional model upgrades, the old model will not be replaced by the new one until the embeddings of all the images in the database are re-computed by the new model, which takes days or weeks for a large amount of data. Recently, backward-compatible training (BCT) enables the new model to be immediately deployed online by making the new embeddings directly comparable to the old ones. For BCT, improving the compatibility of two models with less negative impact on retrieval performance is the key challenge. In this paper, we introduce AdvBCT, an Adversarial Backward-Compatible Training method with an elastic boundary constraint that takes both compatibility and discrimination into consideration. We first employ adversarial learning to minimize the distribution disparity between embeddings of the new model and the old model. Meanwhile, we add an elastic boundary constraint during training to improve compatibility and discrimination efficiently. Extensive experiments on GLDv2, Revisited Oxford (ROxford), and Revisited Paris (RParis) demonstrate that our method outperforms other BCT methods on both compatibility and discrimination. The implementation of AdvBCT will be publicly available at https://github.com/Ashespt/AdvBCT.

In recent years, the explosion of web videos makes text-video retrieval increasingly essential and popular for video filtering, recommendation, and search. Text-video retrieval aims to rank relevant text/video higher than irrelevant ones. The core of this task is to precisely measure the cross-modal similarity between texts and videos. Recently, contrastive learning methods have shown promising results for text-video retrieval, most of which focus on the construction of positive and negative pairs to learn text and video representations. Nevertheless, they do not pay enough attention to hard negative pairs and lack the ability to model different levels of semantic similarity. To address these two issues, this paper improves contrastive learning using two novel techniques. First, to exploit hard examples for robust discriminative power, we propose a novel Dual-Modal Attention-Enhanced Module (DMAE) to mine hard negative pairs from textual and visual clues. By further introducing a Negative-aware InfoNCE (NegNCE) loss, we are able to adaptively identify all these hard negatives and explicitly highlight their impacts in the training loss. Second, our work argues that triplet samples can better model fine-grained semantic similarity compared to pairwise samples. We thereby present a new Triplet Partial Margin Contrastive Learning (TPM-CL) module to construct partial order triplet samples by automatically generating fine-grained hard negatives for matched text-video pairs. The proposed TPM-CL designs an adaptive token masking strategy with cross-modal interaction to model subtle semantic differences. Extensive experiments demonstrate that the proposed approach outperforms existing methods on four widely-used text-video retrieval datasets, including MSR-VTT, MSVD, DiDeMo and ActivityNet.

In this paper, we introduce VCSL (Video Copy Segment Localization), a new comprehensive segment-level annotated video copy dataset. Compared with existing copy detection datasets restricted by either video-level annotation or small-scale, VCSL not only has two orders of magnitude more segment-level labelled data, with 160k realistic video copy pairs containing more than 280k localized copied segment pairs, but also covers a variety of video categories and a wide range of video duration. All the copied segments inside each collected video pair are manually extracted and accompanied by precisely annotated starting and ending timestamps. Alongside the dataset, we also propose a novel evaluation protocol that better measures the prediction accuracy of copy overlapping segments between a video pair and shows improved adaptability in different scenarios. By benchmarking several baseline and state-of-the-art segment-level video copy detection methods with the proposed dataset and evaluation metric, we provide a comprehensive analysis that uncovers the strengths and weaknesses of current approaches, hoping to open up promising directions for future works. The VCSL dataset, metric and benchmark codes are all publicly available at https://github.com/alipay/vCSL.

With the explosive growth of web videos in recent years, large-scale Content-Based Video Retrieval (CBVR) becomes increasingly essential in video filtering, recommendation, and copyright protection. Segment-level CBVR (S-CBVR) locates the start and end time of similar segments in finer granularity, which is beneficial for user browsing efficiency and infringement detection especially in long video scenarios. The challenge of S-CBVR task is how to achieve high temporal alignment accuracy with efficient computation and low storage consumption. In this paper, we propose a Segment Similarity and Alignment Network (SSAN) in dealing with the challenge which is firstly trained end-to-end in S-CBVR. SSAN is based on two newly proposed modules in video retrieval: (1) An efficient Self-supervised Keyframe Extraction (SKE) module to reduce redundant frame features, (2) A robust Similarity Pattern Detection (SPD) module for temporal alignment. In comparison with uniform frame extraction, SKE not only saves feature storage and search time, but also introduces comparable accuracy and limited extra computation time. In terms of temporal alignment, SPD localizes similar segments with higher accuracy and efficiency than existing deep learning methods. Furthermore, we jointly train SSAN with SKE and SPD and achieve an end-to-end improvement. Meanwhile, the two key modules SKE and SPD can also be effectively inserted into other video retrieval pipelines and gain considerable performance improvements. Experimental results on public datasets show that SSAN can obtain higher alignment accuracy while saving storage and online query computational cost compared to existing methods.

We demonstrate a car damage assessment system in car insurance field based on artificial intelligence techniques, which can exempt insurance inspectors from checking cars on site and help people without professional knowledge to evaluate car damages when accidents happen. Unlike existing approaches, we utilize videos instead of photos to interact with users to make the whole procedure as simple as possible. We adopt object and video detection and segmentation techniques in computer vision, and take advantage of multiple frames extracted from videos to achieve high damage recognition accuracy. The system uploads video streams captured by mobile devices, recognizes car damage on the cloud asynchronously and then returns damaged components and repair costs to users. The system evaluates car damages and returns results automatically and effectively in seconds, which reduces laboratory costs and decreases insurance claim time significantly.