The rapid growth and availability of event sequence data across domains requires effective analysis and exploration methods to facilitate decision-making. Visual analytics combines computational techniques with interactive visualizations, enabling the identification of patterns, anomalies, and attribute interactions. However, existing approaches frequently overlook the interplay between temporal and multivariate attributes. We introduce EventBox, a novel data representation and visual encoding approach for analyzing groups of events and their multivariate attributes. We have integrated EventBox into Sequen-C, a visual analytics system for the analysis of event sequences. To enable the agile creation of EventBoxes in Sequen-C, we have added user-driven transformations, including alignment, sorting, substitution and aggregation. To enhance analytical depth, we incorporate automatically generated statistical analyses, providing additional insight into the significance of attribute interactions. We evaluated our approach involving 21 participants (3 domain experts, 18 novice data analysts). We used the ICE-T framework to assess visualization value, user performance metrics completing a series of tasks, and interactive sessions with domain experts. We also present three case studies with real-world healthcare data demonstrating how EventBox and its integration into Sequen-C reveal meaningful patterns, anomalies, and insights. These results demonstrate that our work advances visual analytics by providing a flexible solution for exploring temporal and multivariate attributes in event sequences.

The baroreflex is one of the most important control mechanisms in the human cardiovascular system. This work utilises a closed-loop in silico model of baroreflex regulation, coupled to pulsatile mechanical models with (i) one heart chamber and 36-parameters and (ii) four chambers and 51 parameters. We perform the first global sensitivity analysis of these closed-loop systems which considers both cardiovascular and baroreflex parameters, and compare the models with their respective unregulated equivalents. Results show the reduced influence of regulated parameters compared to unregulated equivalents and that, in the physiological resting state, model outputs (pressures, heart rate, cardiac output etc.) are most sensitive to parasympathetic arc parameters. This work provides insight into the effects of regulation and model input parameter influence on clinical metrics, and constitutes a first step to understanding the role of regulation in models for personalised healthcare.

Digital twins are virtual representations of physical objects or systems used for the purpose of analysis, most often via computer simulations, in many engineering and scientific disciplines. Recently, this approach has been introduced to computational medicine, within the concept of Digital Twin in Healthcare (DTH). Such research requires verification and validation of its models, as well as the corresponding sensitivity analysis and uncertainty quantification (VVUQ). From the computing perspective, VVUQ is a computationally intensive process, as it requires numerous runs with variations of input parameters. Researchers often use high-performance computing (HPC) solutions to run VVUQ studies where the number of parameter combinations can easily reach tens of thousands. However, there is a viable alternative to HPC for a substantial subset of computational models - serverless computing. In this paper we hypothesize that using the serverless computing model can be a practical and efficient approach to selected cases of running VVUQ calculations. We show this on the example of the EasyVVUQ library, which we extend by providing support for many serverless services. The resulting library - CloudVVUQ - is evaluated using two real-world applications from the computational medicine domain adapted for serverless execution. Our experiments demonstrate the scalability of the proposed approach.