A rare disease is any disease that affects a very small percentage (1 in 1,500) of population. It is estimated that there are nearly 7,000 rare disease affecting 30 million patients in the U. S. alone. Most of the patients suffering from rare diseases experience multiple misdiagnoses and may never be diagnosed correctly. This is largely driven by the low prevalence of the disease that results in a lack of awareness among healthcare providers. There have been efforts from machine learning researchers to develop predictive models to help diagnose patients using healthcare datasets such as electronic health records and administrative claims. Most recently, transformer models have been applied to predict diseases BEHRT, G-BERT and Med-BERT. However, these have been developed specifically for electronic health records (EHR) and have not been designed to address rare disease challenges such as class imbalance, partial longitudinal data capture, and noisy labels. As a result, they deliver poor performance in predicting rare diseases compared with baselines. Besides, EHR datasets are generally confined to the hospital systems using them and do not capture a wider sample of patients thus limiting the availability of sufficient rare dis-ease patients in the dataset. To address these challenges, we introduced an extension of the BERT model tailored for rare disease diagnosis called RareBERT which has been trained on administrative claims datasets. RareBERT extends Med-BERT by including context embedding and temporal reference embedding. Moreover, we introduced a novel adaptive loss function to handle the class imbal-ance. In this paper, we show our experiments on diagnosing X-Linked Hypophosphatemia (XLH), a genetic rare disease. While RareBERT performs significantly better than the baseline models (79.9% AUPRC versus 30% AUPRC for Med-BERT), owing to the transformer architecture, it also shows its robustness in partial longitudinal data capture caused by poor capture of claims with a drop in performance of only 1.35% AUPRC, compared with 12% for Med-BERT and 33.0% for LSTM and 67.4% for boosting trees based baseline.

This paper presents a demo of our Security Toolbox to detect novel malware in Android apps. This Toolbox is developed through our recent research project funded by the DARPA Automated Program Analysis for Cybersecurity (APAC) project. The adversarial challenge ("Red") teams in the DARPA APAC program are tasked with designing sophisticated malware to test the bounds of malware detection technology being developed by the research and development ("Blue") teams. Our research group, a Blue team in the DARPA APAC program, proposed a "human-in-the-loop program analysis" approach to detect malware given the source or Java bytecode for an Android app. Our malware detection apparatus consists of two components: a general-purpose program analysis platform called Atlas, and a Security Toolbox built on the Atlas platform. This paper describes the major design goals, the Toolbox components to achieve the goals, and the workflow for auditing Android apps. The accompanying video illustrates features of the Toolbox through a live audit.