Chemosensitivity assays are commonly used for preclinical drug discovery and clinical trial optimization. However, data from independent assays are often discordant, largely attributed to uncharacterized variation in the experimental materials and protocols. We report here the launching of Minimal Information for Chemosensitivity Assays (MICHA), accessed via https://micha-protocol.org. Distinguished from existing efforts that are often lacking support from data integration tools, MICHA can automatically extract publicly available information to facilitate the assay annotation including: 1) compounds, 2) samples, 3) reagents and 4) data processing methods. For example, MICHA provides an integrative web server and database to obtain compound annotation including chemical structures, targets and disease indications. In addition, the annotation of cell line samples, assay protocols and literature references can be greatly eased by retrieving manually curated catalogues. Once the annotation is complete, MICHA can export a report that conforms to the FAIR principle (Findable, Accessible, Interoperable and Reusable) of drug screening studies. To consolidate the utility of MICHA, we provide FAIRified protocols from five major cancer drug screening studies as well as six recently conducted COVID-19 studies. With the MICHA web server and database, we envisage a wider adoption of a community-driven effort to improve the open access of drug sensitivity assays.

We study the problem of controlling a swarm of anonymous, mobile robots to cooperatively cover an unknown two-dimensional space. The novelty of our proposed solution is that it is applicable to extremely simple robots that lack run-time computation or storage. The solution requires only a single bit of information per robot-whether or not another robot is present in its line of sight. Computer simulations show that our deterministic controller, which was obtained through off-line optimization, achieves around 71-76% coverage in a test scenario with no robot redundancy, which corresponds to a 26-39% reduction of the area that is not covered, when compared to an optimized random walk. A moderately lower level of performance was observed in 20 experimental trials with 25 physical e-puck robots. Moreover, we demonstrate that the same controller can be used in environments of different dimensions and even to navigate a maze. The controller provides a baseline against which one can quantify the performance improvements that more advanced and expensive techniques may offer. Moreover, due to its simplicity, it could potentially be implemented on swarms of sub-millimeter-sized robots. This would pave the way for new applications in micro-medicine.

MOTIVATION: ADME SARfari is a freely available web resource that enables comparative analyses of drug-disposition genes. It does so by integrating a number of publicly available data sources, which have subsequently been used to build data mining services, predictive tools and visualizations for drug metabolism researchers. The data include the interactions of small molecules with ADME (absorption, distribution, metabolism and excretion) proteins responsible for the metabolism and transport of molecules; available pharmacokinetic (PK) data; protein sequences of ADME-related molecular targets for pre-clinical model species and human; alignments of the orthologues including information on known SNPs (Single Nucleotide Polymorphism) and information on the tissue distribution of these proteins. In addition, in silico models have been developed, which enable users to predict which ADME relevant protein targets a novel compound is likely to interact with.