Oscar Hernan Madrid Padilla

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19ranked-venue papers
7as first author
17since 2021 · last 2026
0000-0002-2750-7165ORCID · verified

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Artificial intelligence and machine learning · 18 · 6 first-author · 16 since 2021Theory of computation · 1 · 1 first-author · 1 since 2021
YearPublicationVenuePosition
2026 A causal fused lasso for interpretable heterogeneous treatment effects estimation
abstract
We propose a novel method for estimating heterogeneous treatment effects based on the fused lasso. By first ordering samples based on the propensity or prognostic score, we match units from the treatment and control groups. We then run the fused lasso to obtain piecewise constant treatment effects with respect to the ordering defined by the score. Similar to the existing methods based on discretizing the score, our methods yield interpretable subgroup effects. However, existing methods fixed the subgroup a priori, but our causal fused lasso forms data-adaptive subgroups. We show that the estimator consistently estimates the treatment effects conditional on the score under very general conditions on the covariates and treatment. We demonstrate the performance of our procedure using extensive experiments that show that it can be interpretable and competitive with state-of-the-art methods.
Oscar Hernan Madrid Padilla, Yanzhen Chen, Carlos Misael Madrid Padilla, Gabriel Ruiz
J. Mach. Learn. Res.1
2025 Statistical Guarantees for Lifelong Reinforcement Learning using PAC-Bayes Theory
abstract
Lifelong reinforcement learning (RL) has been developed as a paradigm for extending single-task RL to more realistic, dynamic settings. In lifelong RL, the "life" of an RL agent is modeled as a stream of tasks drawn from a task distribution. We propose EPIC (Empirical PAC-Bayes that Improves Continuously), a novel algorithm designed for lifelong RL using PAC-Bayes theory. EPIC learns a shared policy distribution, referred to as the world policy, which enables rapid adaptation to new tasks while retaining valuable knowledge from previous experiences. Our theoretical analysis establishes a relationship between the algorithm’s generalization performance and the number of prior tasks preserved in memory. We also derive the sample complexity of EPIC in terms of RL regret. Extensive experiments on a variety of environments demonstrate that EPIC significantly outperforms existing methods in lifelong RL, offering both theoretical guarantees and practical efficacy through the use of the world policy.
Zhi Zhang 0012, Chris Chow, Yasi Zhang, Yanchao Sun, Eric Hanchen Jiang, Han Liu 0001, Furong Huang, Yuchen Cui, Oscar Hernan Madrid Padilla
AISTATS10
2025 Quantile Additive Trend Filtering
abstract
This paper introduces and analyzes quantile additive trend filtering, a novel approach to model the conditional quantiles of the response variable given multivariate covariates. Under the assumption that the true model is additive, and that the components are functions whose $r$th order weak derivatives have bounded total variation, our estimator is a constrained version of quantile trend filtering within additive models. The primary theoretical contributions are the error rate of our estimator in both fixed and growing input dimensions. In the fixed dimension case, we show that our estimator attains a rate that mirrors the non-quantile minimax rate for additive trend filtering, featuring the main term $n^{-2r/(2r+1)}$. For growing input dimension ($d$), our rate has an additional polynomial factor $d^{(2r+2)/(2r+1)}$. We propose a practical algorithm for implementing quantile additive trend filtering using dimension-wise backfitting. Experiments in both real data and simulations confirm our theoretical findings. We provide a public implementation of the algorithm at \url{https://github.com/zzh237/QATF.}
Zhi Zhang 0012, Kyle Ritscher, Oscar Hernan Madrid Padilla
AISTATS3
2025 Network two-sample test for block models
abstract
We consider the two-sample testing problem for networks, where the goal is to determine whether two sets of networks originated from the same stochastic model. Assuming no vertex correspondence and allowing for different numbers of nodes, we address a fundamental network testing problem that goes beyond simple adjacency matrix comparisons. We adopt the stochastic block model (SBM) for network distributions, due to their interpretability and the potential to approximate more general models. The lack of meaningful node labels and vertex correspondence translate to a graph matching challenge when developing a test for SBMs. We introduce an efficient algorithm to match estimated network parameters, allowing us to properly combine and contrast information within and across samples, leading to a powerful test. We show that the matching algorithm, and the overall test are consistent, under mild conditions on the sparsity of the networks and the sample sizes, and derive a chi-squared asymptotic null distribution for the test. Through a mixture of theoretical insights and empirical validations, including experiments with both synthetic and real-world data, this study advances robust statistical inference for complex network data.
Chung Kyong Nguen, Arash A. Amini, Oscar Hernan Madrid Padilla
NeurIPS3
2025 Risk Bounds For Distributional Regression
abstract
This work examines risk bounds for nonparametric distributional regression estimators. For convex-constrained distributional regression, general upper bounds are established for the continuous ranked probability score (CRPS) and the worst-case mean squared error (MSE) across the domain. These theoretical results are applied to isotonic and trend filtering distributional regression, yielding convergence rates consistent with those for mean estimation. Furthermore, a general upper bound is derived for distributional regression under non-convex constraints, with a specific application to neural network-based estimators. Comprehensive experiments on both simulated and real data validate the theoretical contributions, demonstrating their practical effectiveness.
Carlos Misael Madrid Padilla, Oscar Hernan Madrid Padilla, Sabyasachi Chatterjee
NeurIPS2
2025 Bayesian Variance Change Point Detection With Credible Sets
abstract
This paper introduces a novel Bayesian approach to detect changes in the variance of a Gaussian sequence model, focusing on quantifying the uncertainty in the change point locations and providing a scalable algorithm for inference. We do that by framing the problem as a product of multiple single changes in the scale parameter. We fit the model through an iterative procedure similar to what is done for additive models. The novelty is that each iteration returns a probability distribution on time instances, which captures the uncertainty in the change point location. Leveraging a recent result in the literature, we can show that our proposal is a variational approximation of the exact model posterior distribution. We study the convergence of the algorithm and the change point localization rate. Extensive experiments in simulation studies and applications to biological data illustrate the performance of our method.
Lorenzo Cappello, Oscar Hernan Madrid Padilla
IEEE Trans. Pattern Anal. Mach. Intell.2
2024 Learning Gaussian DAGs from Network Data
abstract
Structural learning of directed acyclic graphs (DAGs) or Bayesian networks has been studied extensively under the assumption that the data are independent. We propose a new Gaussian DAG model for dependent data which assumes the observations are correlated according to an undirected network. Under this model, we develop a method to estimate the DAG structure given a topological ordering of the nodes. The proposed method jointly estimates the Bayesian network and the correlations among observations by optimizing a scoring function based on penalized likelihood. We show that under some mild conditions, the proposed method produces consistent estimators after one iteration. Extensive numerical experiments also demonstrate that, by jointly estimating the DAG structure and the sample correlation, our method achieves much higher accuracy in structure learning. When the node ordering is unknown, through experiments on synthetic and real data, we show that our algorithm can be used to estimate the correlations between samples, with which we can de-correlate the dependent data to significantly improve the performance of classical DAG learning methods.
Hangjian Li, Oscar Hernan Madrid Padilla
J. Mach. Learn. Res.2
2024 Variance estimation in graphs with the fused lasso
abstract
We study the problem of variance estimation in general graph-structured problems. First, we develop a linear time estimator for the homoscedastic case that can consistently estimate the variance in general graphs. We show that our estimator attains minimax rates for the chain and 2D grid graphs when the mean signal has total variation with canonical scaling. Furthermore, we provide general upper bounds on the mean squared error performance of the fused lasso estimator in general graphs under a moment condition and a bound on the tail behavior of the errors. These upper bounds allow us to generalize for broader classes of distributions, such as sub-Exponential, many existing results on the fused lasso that are only known to hold with the assumption that errors are sub-Gaussian random variables. Exploiting our upper bounds, we then study a simple total variation regularization estimator for estimating the signal of variances in the heteroscedastic case. We also provide lower bounds showing that our heteroscedastic variance estimator attains minimax rates for estimating signals of bounded variation in grid graphs, and $K$-nearest neighbor graphs, and the estimator is consistent for estimating the variances in any connected graph.
Oscar Hernan Madrid Padilla
J. Mach. Learn. Res.1
2023 Change point detection and inference in multivariate non-parametric models under mixing conditions
abstract
This paper addresses the problem of localizing and inferring multiple change points, in non-parametric multivariate time series settings. Specifically, we consider a multivariate time series with potentially short-range dependence, whose underlying distributions have Hölder smooth densities and can change over time in a piecewise-constant manner. The change points, which correspond to the times when the distribution changes, are unknown. We present the limiting distributions of the change point estimators under the scenarios where the minimal jump size vanishes or remains constant. Such results have not been revealed in the literature in non-parametric change point settings. As byproducts, we develop a sharp estimator that can accurately localize the change points in multivariate non-parametric time series, and a consistent block-type long-run variance estimator. Numerical studies are provided to complement our theoretical findings.
Carlos Misael Madrid Padilla, Daren Wang, Oscar Hernan Madrid Padilla, Yi Yu 0016
NeurIPS4
2022 Denoising and change point localisation in piecewise-constant high-dimensional regression coefficients
abstract
We study the theoretical properties of the fused lasso procedure originally proposed by Tibshirani et al. (2005) in the context of a linear regression model in which the regression coefficient are totally ordered and assumed to be sparse and piecewise constant. Despite its popularity, to the best of our knowledge, estimation error bounds in high-dimensional settings have only been obtained for the simple case in which the design matrix is the identity matrix. We formulate a novel restricted isometry condition on the design matrix that is tailored to the fused lasso estimator and derive estimation bounds for both the constrained version of the fused lasso assuming dense coefficients and for its penalised version. We observe that the estimation error can be dominated by either the lasso or the fused lasso rate, depending on whether the number of non-zero coefficient is larger than the number of piece-wise constant segments. Finally, we devise a post-processing procedure to recover the piecewise-constant pattern of the coefficients. Extensive numerical experiments support our theoretical findings.
Oscar Hernan Madrid Padilla, Yi Yu 0016, Alessandro Rinaldo
AISTATS2
2022 Optimal partition recovery in general graphs
abstract
We consider a graph-structured change point problem in which we observe a random vector with piece-wise constant but otherwise unknown mean and whose independent, sub-Gaussian coordinates correspond to the $n$ nodes of a fixed graph. We are interested in the localisation task of recovering the partition of the nodes associated to the constancy regions of the mean vector or, equivalently, of estimating the cut separating the sub-graphs over which the mean remains constant. Although graph-valued signals of this type have been previously studied in the literature for the different tasks of testing for the presence of an anomalous cluster and of estimating the mean vector, no localisation results are known outside the classical case of chain graphs. When the partition $\mathcal{S}$ consists of only two elements, we characterise the difficulty of the localisation problem in terms of four key parameters: the maximal noise variance $\sigma^2$, the size $\Delta$ of the smaller element of the partition, the magnitude $\kappa$ of the difference in the signal values across contiguous elements of the partition and the sum of the effective resistance edge weights $|\partial_r(\mathcal{S})|$ of the corresponding cut – a graph theoretic quantity quantifying the size of the partition boundary. In particular, we demonstrate an information theoretical lower bound implying that, in the low signal-to-noise ratio regime $\kappa^2 \Delta \sigma^{-2} |\partial_r(\mathcal{S})|^{-1} \lesssim 1$, no consistent estimator of the true partition exists. On the other hand, when $\kappa^2 \Delta \sigma^{-2} |\partial_r(\mathcal{S})|^{-1} \gtrsim \zeta_n \log\{r(|E|)\}$, with $r(|E|)$ being the sum of effective resistance weighted edges and $\zeta_n$ being any diverging sequence in $n$, we show that a polynomial-time, approximate $\ell_0$-penalised least squared estimator delivers a localisation error – measured by the symmetric difference between the true and estimated partition – of order $ \kappa^{-2} \sigma^2 |\partial_r(\mathcal{S})| \log\{r(|E|)\}$. Aside from the $\log\{r(|E|)\}$ term, this rate is minimax optimal. Finally, we provide discussions on the localisation error for more general partitions of unknown sizes.
Yi Yu 0016, Oscar Hernan Madrid Padilla, Alessandro Rinaldo
AISTATS2
2022 Extensions to the Proximal Distance Method of Constrained Optimization
abstract
The current paper studies the problem of minimizing a loss $f(\boldsymbol{x})$ subject to constraints of the form $\boldsymbol{D}\boldsymbol{x} \in S$, where $S$ is a closed set, convex or not, and $\boldsymbol{D}$ is a matrix that fuses parameters. Fusion constraints can capture smoothness, sparsity, or more general constraint patterns. To tackle this generic class of problems, we combine the Beltrami-Courant penalty method of optimization with the proximal distance principle. The latter is driven by minimization of penalized objectives $f(\boldsymbol{x})+\frac{\rho}{2}\text{dist}(\boldsymbol{D}\boldsymbol{x},S)^2$ involving large tuning constants $\rho$ and the squared Euclidean distance of $\boldsymbol{D}\boldsymbol{x}$ from $S$. The next iterate $\boldsymbol{x}_{n+1}$ of the corresponding proximal distance algorithm is constructed from the current iterate $\boldsymbol{x}_n$ by minimizing the majorizing surrogate function $f(\boldsymbol{x})+\frac{\rho}{2}\|\boldsymbol{D}\boldsymbol{x}-\mathcal{P}_{S}(\boldsymbol{D}\boldsymbol{x}_n)\|^2$. For fixed $\rho$ and a subanalytic loss $f(\boldsymbol{x})$ and a subanalytic constraint set $S$, we prove convergence to a stationary point. Under stronger assumptions, we provide convergence rates and demonstrate linear local convergence. We also construct a steepest descent variant to avoid costly linear system solves. To benchmark our algorithms, we compare their results to those delivered by the alternating direction method of multipliers. Our extensive numerical tests include problems on metric projection, convex regression, convex clustering, total variation image denoising, and projection of a matrix to a good condition number. These experiments demonstrate the superior speed and acceptable accuracy of our steepest variant on high-dimensional problems.
Alfonso Landeros, Oscar Hernan Madrid Padilla, Hua Zhou 0001, Kenneth Lange
J. Mach. Learn. Res.2
2022 Quantile regression with ReLU Networks: Estimators and minimax rates
abstract
Quantile regression is the task of estimating a specified percentile response, such as the median (50th percentile), from a collection of known covariates. We study quantile regression with rectified linear unit (ReLU) neural networks as the chosen model class. We derive an upper bound on the expected mean squared error of a ReLU network used to estimate any quantile conditioning on a set of covariates. This upper bound only depends on the best possible approximation error, the number of layers in the network, and the number of nodes per layer. We further show upper bounds that are tight for two large classes of functions: compositions of Hölder functions and members of a Besov space. These tight bounds imply ReLU networks with quantile regression achieve minimax rates for broad collections of function types. Unlike existing work, the theoretical results hold under minimal assumptions and apply to general error distributions, including heavy-tailed distributions. Empirical simulations on a suite of synthetic response functions demonstrate the theoretical results translate to practical implementations of ReLU networks. Overall, the theoretical and empirical results provide insight into the strong performance of ReLU neural networks for quantile regression across a broad range of function classes and error distributions. All code for this paper is publicly available at https://github.com/tansey/quantile-regression.
Oscar Hernan Madrid Padilla, Wesley Tansey, Yanzhen Chen
J. Mach. Learn. Res.1
2022 Change point localization in dependent dynamic nonparametric random dot product graphs
abstract
In this paper, we study the offline change point localization problem in a sequence of dependent nonparametric random dot product graphs. To be specific, assume that at every time point, a network is generated from a nonparametric random dot product graph model (see e.g. Athreya et al., 2018), where the latent positions are generated from unknown underlying distributions. The underlying distributions are piecewise constant in time and change at unknown locations, called change points. Most importantly, we allow for dependence among networks generated between two consecutive change points. This setting incorporates edge-dependence within networks and temporal dependence between networks, which is the most flexible setting in the published literature. To accomplish the task of consistently localizing change points, we propose a novel change point detection algorithm, consisting of two steps. First, we estimate the latent positions of the random dot product model, our theoretical result being a refined version of the state-of-the-art results, allowing the dimension of the latent positions to diverge. Subsequently, we construct a nonparametric version of the CUSUM statistic (e.g. Page, 1954; Padilla et al., 2019a) that allows for temporal dependence. Consistent localization is proved theoretically and supported by extensive numerical experiments, which illustrate state-of-the-art performance. We also provide in depth discussion of possible extensions to give more understanding and insights.
Oscar Hernan Madrid Padilla, Yi Yu 0016, Carey E. Priebe
J. Mach. Learn. Res.1
2022 Optimal Nonparametric Multivariate Change Point Detection and Localization
abstract
We study the multivariate nonparametric change point detection problem, where the data are a sequence of independent$p$-dimensional random vectors whose distributions are piecewise-constant with Lipschitz densities changing at unknown times, called change points. We quantify the size of the distributional change at any change point with the supremum norm of the difference between the corresponding densities. We are concerned with the localization task of estimating the positions of the change points. In our analysis, we allow for the model parameters to vary with the total number of time points, including the minimal spacing between consecutive change points and the magnitude of the smallest distributional change. We provide information-theoretic lower bounds on both the localization rate and the minimal signal-to-noise ratio required to guarantee consistent localization. We formulate a novel algorithm based on kernel density estimation that nearly achieves the minimax lower bound, save possibly for logarithm factors. We have provided extensive numerical evidence to support our theoretical findings.
Oscar Hernan Madrid Padilla, Yi Yu 0016, Daren Wang, Alessandro Rinaldo
IEEE Trans. Inf. Theory1
2021 Lattice partition recovery with dyadic CART
abstract
We study piece-wise constant signals corrupted by additive Gaussian noise over a $d$-dimensional lattice. Data of this form naturally arise in a host of applications, and the tasks of signal detection or testing, de-noising and estimation have been studied extensively in the statistical and signal processing literature. In this paper we consider instead the problem of partition recovery, i.e.~of estimating the partition of the lattice induced by the constancy regions of the unknown signal, using the computationally-efficient dyadic classification and regression tree (DCART) methodology proposed by \citep{donoho1997cart}. We prove that, under appropriate regularity conditions on the shape of the partition elements, a DCART-based procedure consistently estimates the underlying partition at a rate of order $\sigma^2 k^* \log (N)/\kappa^2$, where $k^*$ is the minimal number of rectangular sub-graphs obtained using recursive dyadic partitions supporting the signal partition, $\sigma^2$ is the noise variance, $\kappa$ is the minimal magnitude of the signal difference among contiguous elements of the partition and $N$ is the size of the lattice. Furthermore, under stronger assumptions, our method attains a sharper estimation error of order $\sigma^2\log(N)/\kappa^2$, independent of $k^*$, which we show to be minimax rate optimal. Our theoretical guarantees further extend to the partition estimator based on the optimal regression tree estimator (ORT) of \cite{chatterjee2019adaptive} and to the one obtained through an NP-hard exhaustive search method. We corroborate our theoretical findings and the effectiveness of DCART for partition recovery in simulations.
Oscar Hernan Madrid Padilla, Yi Yu 0016, Alessandro Rinaldo
NeurIPS1
2021 Non-parametric Quantile Regression via the K-NN Fused Lasso
abstract
Quantile regression is a statistical method for estimating conditional quantiles of a response variable. In addition, for mean estimation, it is well known that quantile regression is more robust to outliers than $l_2$-based methods. By using the fused lasso penalty over a $K$-nearest neighbors graph, we propose an adaptive quantile estimator in a non-parametric setup. We show that the estimator attains optimal rate of $n^{-1/d}$ up to a logarithmic factor, under mild assumptions on the data generation mechanism of the $d$-dimensional data. We develop algorithms to compute the estimator and discuss methodology for model selection. Numerical experiments on simulated and real data demonstrate clear advantages of the proposed estimator over state of the art methods.
Steven Siwei Ye, Oscar Hernan Madrid Padilla
J. Mach. Learn. Res.2
2017 The DFS Fused Lasso: Linear-Time Denoising over General Graphs
Oscar Hernan Madrid Padilla, James Sharpnack, James G. Scott, Ryan J. Tibshirani
J. Mach. Learn. Res.1
2015 Vector-Space Markov Random Fields via Exponential Families
abstract
We present Vector-Space Markov Random Fields (VS-MRFs), a novel class of undirected graphical models where each variable can belong to an arbitrary vector space. VS-MRFs generalize a recent line of work on scalar-valued, uni-parameter exponential family and mixed graphical models, thereby greatly broadening the class of exponential families available (e.g., allowing multinomial and Dirichlet distributions). Specifically, VS-MRFs are the joint graphical model distributions where the node-conditional distributions belong to generic exponential families with general vector space domains. We also present a sparsistent M-estimator for learning our class of MRFs that recovers the correct set of edges with high probability. We validate our approach via a set of synthetic data experiments as well as a real-world case study of over four million foods from the popular diet tracking app MyFitnessPal. Our results demonstrate that our algorithm performs well empirically and that VS-MRFs are capable of capturing and highlighting interesting structure in complex, real-world data. All code for our algorithm is open source and publicly available.
Wesley Tansey, Oscar Hernan Madrid Padilla, Arun Suggala, Pradeep Ravikumar
ICML2