We study the discovery of cliques (or "complete" subgraphs) in heterogeneous information networks (HINs). Existing clique-finding solutions often ignore the rich semantics of HINs. We propose motif clique, or m-clique, which redefines subgraph completeness with respect to a given motif. A motif, essentially a small subgraph pattern, is a fundamental building block of an HIN. The m-clique concept is general and allows us to analyse "complete" subgraphs in an HIN with respect to desired high-order connection patterns. We further investigate the maximal m-clique enumeration problem (MMCE), which finds all maximal m-cliques not contained in any other m-cliques. Because MMCE is NP-hard, developing an accurate and efficient solution for MMCE is not straightforward. We thus present the META algorithm, which employs advanced pruning strategies to effectively reduce the search space. We also design fast techniques to avoid generating duplicated maximal m-clique instances. Our extensive experiments on large real and synthetic HINs show that META is highly effective and efficient.

We genetically improve BarraCUDA using a BNF grammar incorporating C scoping rules with GP. Barracuda maps next generation DNA sequences to the human genome using the Burrows-Wheeler algorithm (BWA) on nVidia Tesla parallel graphics hardware (GPUs). GI using phenotypic tabu search with manually grown code can graft new features giving more than 100 fold speed up on a performance critical kernel without loss of accuracy.