This article documents thermophysiological patterns associated with migraine episodes, where the inner canthi and supraorbital temperatures drop significantly compared to normal conditions. These temperature drops are likely due to vasoconstriction of the ophthalmic arteries under the inner canthi and sympathetic activation of the eccrine glands in the supraorbital region, respectively. The thermal patterns were observed on eight migraine patients and meticulously quantified using advance computational methods, capable of delineating small anatomical structures in thermal imagery and tracking them automatically over time. These methods open the way for monitoring migraine episodes in nonclinical environments, where the patient maintains directional attention, such as his/her computer at home or at work. This development has the potential to significantly expand the operational envelope of migraine studies.

Electrodermal activity (EDA) is an important affective indicator, measured conventionally on the fingers with desktop sensing instruments. Recently, a new generation of wearable, battery-powered EDA devices came into being, encouraging the migration of EDA sensing to other body locations. To investigate the implications of such sensor/location shifts in psychophysiological studies we performed a validation experiment. In this experiment we used startle stimuli to instantaneously arouse the sympathetic system of n=23 subjects while sitting. Startle stimuli are standard but minimal stressors, and thus ideal for determining the sensor and location resolution limit. The experiment revealed that precise measurement of small EDA responses on the fingers and palm is feasible either with conventional or mobile EDA sensors. By contrast, precise measurement of small EDA responses on the sole is challenging, while on the wrist even detection of such responses is problematic for both EDA modalities. Given that affective wristbands have emerged as the dominant form of EDA sensing, researchers should beware of these limitations.

This study explored various user interface designs to transition a two dimensional (2D) questionnaire from its paper-and-pencil testing format to the mobile platform. The current administration of the test limits its usage beyond the lab environment. Creating a mobile version would facilitate ubiquitous administration of the test. Yet, the mobile design must be at least as good as its paper-based counterpart in terms of input accuracy and user interaction efforts. We developed four user interface designs, each of which featured a specific interaction approach. These approaches included displaying the 2D space of the questionnaire in its original form (M1), inputting one variable at a time on the 2D space (M2), dissolving the 2D space into two one-dimensional ordinal scales (M3), and orienting the input selections to the diagonal axes (M4). The designs were tested by a total of 34 participants, aged 18 to 52 years. The study results find the first three interaction approaches (M1-M3) effective but the fourth approach inefficient. Furthermore, the results indicate that the two-tap designs (M2 and M3) are equally as good as the one-tap design (M1).