Reconstructing dynamic objects from monocular RGB-D video is critical for advancing 3D vision applications and enhancing user experience. However, monocular RGB-D video provides limited 3D observations, making the reconstruction of unobserved regions highly under-constrained. Despite recent advances that combine neural implicit surfaces with diffusion models, the inherent limitations of implicit representations and the lack of effective guidance in diffusion priors lead to blurry appearance and inaccurate geometry in dynamic object reconstruction. To address the issue, we present MGD, which leverages scene-adaptive diffusion priors and Mesh-guided Gaussians for realistic rendering and geometrically accurate reconstruction of dynamic objects, including unobserved regions. The dynamic 3D objects reconstructed by MGD are represented using our proposed Mesh-guided Gaussians, which leverage global and local Gaussians to capture large-scale deformations and fine-grained appearance details, respectively. Additionally, in order to utilize depth information, we integrate a depth ControlNet into the diffusion model and conduct scene-adaptive fine-tuning. We design a self-generated image-pair strategy to produce image pairs used for fine-tuning. Extensive experiments demonstrate that MGD achieves state-of-the-art performance in both high-fidelity reconstruction and structural completeness, while maintaining real-time efficiency during training and rendering.

Target prediction and virtual screening are two powerful tools of computer-aided drug design. Target identification is of great significance for hit discovery, lead optimization, drug repurposing and elucidation of the mechanism. Virtual screening can improve the hit rate of drug screening to shorten the cycle of drug discovery and development. Therefore, target prediction and virtual screening are of great importance for developing highly effective drugs against COVID-19. Here we present D3AI-CoV, a platform for target prediction and virtual screening for the discovery of anti-COVID-19 drugs. The platform is composed of three newly developed deep learning-based models i.e., MultiDTI, MPNNs-CNN and MPNNs-CNN-R models. To compare the predictive performance of D3AI-CoV with other methods, an external test set, named Test-78, was prepared, which consists of 39 newly published independent active compounds and 39 inactive compounds from DrugBank. For target prediction, the areas under the receiver operating characteristic curves (AUCs) of MultiDTI and MPNNs-CNN models are 0.93 and 0.91, respectively, whereas the AUCs of the other reported approaches range from 0.51 to 0.74. For virtual screening, the hit rate of D3AI-CoV is also better than other methods. D3AI-CoV is available for free as a web application at http://www.d3pharma.com/D3Targets-2019-nCoV/D3AI-CoV/index.php, which can serve as a rapid online tool for predicting potential targets for active compounds and for identifying active molecules against a specific target protein for COVID-19 treatment.

Due to the rapid increase of mobile user population and the dynamical change of network topology in mobile social networks (MSNs), how to efficiently deliver content among mobile social users becomes a new challenge. In this paper, an incentive content delivery mechanism based on the weighted directed graph is proposed to encourage users to obtain and provide content in the MSNs. Specifically, firstly we introduce a weighted directed graph to study the features of obtaining and providing content among mobile social users. Secondly, based on the social features including the average closeness and vertex betweenness, we present the sealed-bid auction based incentive mechanism to overcome selfish behavior and efficiently deliver content in the MSNs. Finally, with a real dataset numerical experiments are carried out to prove that the proposal can accurately show the properties of the MSNs and can be efficient for content delivery.