Robotic assistance for experimental manipulation in the life sciences is expected to enable favorable outcomes, regardless of the skill of the scientist. Experimental specimens in the life sciences are subject to individual variability and hence require intricate algorithms for successful autonomous robotic control. As a use case, we are studying the cranial window creation in mice. This operation requires the removal of an 8-mm circular patch of the skull, which is approximately 300 μm thick, but the shape and thickness of the mouse skull significantly varies depending on the strain of the mouse, sex, and age. In this work, we develop an autonomous robotic drilling system with no offline planning, consisting of a trajectory planner with execution-time feedback with drilling completion level recognition based on image and force information. In the experiments, we first evaluate the image-and-force-based drilling completion level recognition by comparing it with other state-of-the-art deep learning image processing methods and conduct an ablation study in eggshell drilling to evaluate the impact of each module on system performance. Finally, the system performance is further evaluated in postmortem mice, achieving a success rate of 70% (14/20 trials) with an average drilling time of 9.3 min.

Robotic systems for manipulation in millimeter scale often use a camera with high magnification for visual feedback of the target region. However, the limited field-of-view (FoV) of the microscopic camera necessitates camera motion to capture a broader workspace environment. In this work, we propose an autonomous robotic control method to constrain a robot-held camera within a designated FoV. Furthermore, we model the camera extrinsics as part of the kinematic model and use camera measurements coupled with a U-Net based tool tracking to adapt the complete robotic model during task execution. As a proof-of-concept demonstration, the proposed framework was evaluated in a bi-manual setup, where the microscopic camera was controlled to view a tool moving in a pre-defined trajectory. The proposed method allowed the camera to stay 94.1% of the time within the real FoV, compared to 54.4% without the proposed adaptive control.

Vitreoretinal surgery pertains to the treatment of delicate tissues on the fundus of the eye using thin instruments. Surgeons frequently rotate the eye during surgery, which is called orbital manipulation, to observe regions around the fundus without moving the patient. In this paper, we propose the autonomous orbital manipulation of the eye in robot-assisted vitreoretinal surgery with our tele-operated surgical system. In a simulation study, we preliminarily investigated the increase in the manipulability of our system using orbital manipulation. Furthermore, we demonstrated the feasibility of our method in experiments with a physical robot and a realistic eye model, showing an increase in the view-able area of the fundus when compared to a conventional technique. Source code and minimal example available at https://github.com/mmmarinho/icra2023_orbitalmanipulation.

Robot teleoperation has been studied for the past 70 years and is relevant in many contexts, such as in the handling of hazardous materials and telesurgery. The COVID19 pandemic has rekindled interest in this topic, but the existing robotic education kits fall short of being suitable for teleoperated robotic manipulator learning. In addition, the global restrictions of motion motivated large investments in online/hybrid education. In this work, a newly developed robotics education kit and its ecosystem are presented which is used as the backbone of an online/hybrid course in teleoperated robots. The students are divided into teams. Each team designs, fabricates (3D printing and assembling), and implements a control strategy for a master device and gripper. Coupling those with the UMIRobot, provided as a kit, the students compete in a teleoperation challenge. The kit is low cost (<100USD), which allows higher-learning institutions to provide one kit per student and they can learn in a risk-free environment. As of now, 73 such kits have been assembled and sent to course participants in eight countries. As major success stories, we show an example of gripper and master designed for the proposed course. In addition, we show a teleoperated task between Japan and Bangladesh executed by course participants. Design files, videos, source code, and more information are available at https://mmmarinho.github.io/UMIRobot/

Robotic assistance for experimental manipulation in the life sciences is expected to enable precise manipulation of valuable samples, regardless of the skill of the scientist. Experimental specimens in the life sciences are subject to individual variability and deformation, and therefore require autonomous robotic control. As an example, we are studying the installation of a cranial window in a mouse. This operation requires the removal of the skull, which is approximately 300 um thick, to cut it into a circular shape 8 mm in diameter, but the shape of the mouse skull varies depending on the strain of mouse, sex and week of age. The thickness of the skull is not uniform, with some areas being thin and others thicker. It is also difficult to ensure that the skulls of the mice are kept in the same position for each operation. It is not realistically possible to measure all these features and pre-program a robotic trajectory for individual mice. The paper therefore proposes an autonomous robotic drilling method. The proposed method consists of drilling trajectory planning and image-based task completion level recognition. The trajectory planning adjusts the z-position of the drill according to the task completion level at each discrete point, and forms the 3D drilling path via constrained cubic spline interpolation while avoiding overshoot. The task completion level recognition uses a DSSD-inspired deep learning model to estimate the task completion level of each discrete point. Since an egg has similar characteristics to a mouse skull in terms of shape, thickness and mechanical properties, removing the egg shell without damaging the membrane underneath was chosen as the simulation task. The proposed method was evaluated using a 6-DOF robotic arm holding a drill and achieved a success rate of 80% out of 20 trials.

Recent advancements in constrained kinematic control make it an attractive strategy for controlling robots with arbitrary geometry in challenging tasks. Most of the current works assume that the robot kinematic model is precise enough for the task at hand. However, with increasing demands and safety requirements in robotic applications, there is a need for a controller that compensates online for kinematic inaccuracies. We propose an adaptive constrained kinematic control strategy based on quadratic programming, which uses partial or complete task-space measurements to compensate online for calibration errors. Our method is validated in experiments that show increased accuracy and safety compared to a state-of-the-art kinematic control strategy.

Surgical robots are usually controlled using a priori models based on the robots’ geometric parameters, which are calibrated before the surgical procedure. One of the challenges in using robots in real surgical settings is that those parameters can change over time, consequently deteriorating control accuracy. In this context, our group has been investigating online calibration strategies without added sensors. In one step toward that goal, we have developed an algorithm to estimate the pose of the instruments’ shafts in endoscopic images. In this study, we build upon that earlier work and propose a new framework to more precisely estimate the pose of a rigid surgical instrument. Our strategy is based on a novel pose estimation model called MBAPose and the use of synthetic training data. Our experiments demonstrated an improvement of 21 % for translation error and 26 % for orientation error on synthetic test data with respect to our previous work. Results with real test data provide a baseline for further research.

Surgical robots are used to perform minimally invasive surgery and alleviate much of the burden imposed on surgeons. Our group has developed a surgical robot to aid in the removal of tumors at the base of the skull via access through the nostrils. To avoid injuring the patients, a collision-avoidance algorithm that depends on having an accurate model for the poses of the instruments' shafts is used. Given that the model's parameters can change over time owing to interactions between instruments and other disturbances, the online estimation of the poses of the instrument's shaft is essential. In this work, we propose a new method to estimate the pose of the surgical instruments' shafts using a monocular endoscope. Our method is based on the use of an automatically annotated training dataset and an improved pose-estimation deep-learning architecture. In preliminary experiments, we show that our method can surpass state of the art vision-based marker-less pose estimation techniques (providing an error decrease of 55% in position estimation, 64% in pitch, and 69% in yaw) by using artificial images.

In adult laparoscopy, robot-aided surgery is a reality in thousands of operating rooms worldwide, owing to the increased dexterity provided by the robotic tools. Many robots and robot control techniques have been developed to aid in more challenging scenarios, such as pediatric surgery and microsurgery. However, the prevalence of case-specific solutions, particularly those focused on non-redundant robots, reduces the reproducibility of the initial results in more challenging scenarios. In this paper, we propose a general framework for the control of surgical robotics in constrained workspaces under teleoperation, regardless of the robot geometry. Our technique is divided into a slave-side constrained optimization algorithm, which provides virtual fixtures, and with Cartesian impedance on the master side to provide force feedback. Experiments with two robotic systems, one redundant and one non-redundant, show that smooth teleoperation can be achieved in adult laparoscopy and infant surgery.

Robotic assistance allows surgeons to perform dexterous and tremor-free procedures, but robotic aid is still under-represented in procedures with constrained workspaces, such as deep brain neurosurgery and endonasal surgery. In these procedures, surgeons have restricted vision to areas near the surgical tooltips, which increases the risk of unexpected collisions between the shafts of the instruments and their surroundings. In this paper, our vector-field-inequalities method is extended to provide dynamic active-constraints to any number of robots and moving objects sharing the same workspace. The method is evaluated with experiments and simulations in which robot tools have to avoid collisions autonomously and in real-time, in a constrained endonasal surgical environment. Simulations show that with our method the combined trajectory error of two robotic systems is optimal. Experiments using a real robotic system show that the method can autonomously prevent collisions between the moving robots themselves and between the robots and the environment. Moreover, the framework is also successfully verified under teleoperation with tool-tissue interactions.

Robotic assistance allows surgeons to perform dexterous and tremor-free procedures, but is still underrepresented in deep brain neurosurgery and endonasal surgery where the workspace is constrained. In these conditions, the vision of surgeons is restricted to areas near the surgical tool tips, which increases the risk of unexpected collisions between the shafts of the instruments and their surroundings, in particular in areas outside the surgical field-of-view. Active constraints can be used to prevent the tools from entering restricted zones and thus avoid collisions. In this paper, a vector field inequality is proposed that guarantees that tools do not enter restricted zones. Moreover, in contrast with early techniques, the proposed method limits the tool approach velocity in the direction of the forbidden zone boundary, guaranteeing a smooth behavior and that tangential velocities will not be disturbed. The proposed method is evaluated in simulations featuring two eight degrees-of-freedom manipulators that were custom-designed for deep neurosurgery. The results show that both manipulator-manipulator and manipulator-boundary collisions can be avoided using the vector field inequalities.

This work addresses the task-space design problem of a linear-quadratic optimal tracking controller for robotic manipulators using the unit dual quaternion formalism. The efficiency, compactness, and lack of singularity of the representation render the unit dual quaternion a suitable framework for simultaneously describing the attitude and the position of the end-effector. Motivated by the advantages of this kinematic description, we propose a new task-space linear-quadratic optimal tracking controller in order to find an optimal trajectory for the end-effector, providing a tool to balance more conveniently the end-effector error and its task-space velocity. This is possible because the kinematic control problem using the dual quaternion transformation invariant error can be reduced to an affine time-varying system. The proposed optimal tracking controller allows the compensation of trajectory induced disturbances, as well as other modeled additive disturbances and known bias. Simulation results with different design parameters provide a performance overview, in comparison with standard kinematic controllers with and without a feed-forward term, for tracking a desired reference.