Glaucoma is the leading cause of irreversible blindness worldwide. The clinical standard for glaucoma diagnosis and progression tracking remains visual field (VF) testing via standard automated perimetry. One outstanding challenge of many ophthalmic prediction tasks is the issue of class imbalance, where the majority class outnumbers the minority class(es). Although this issue has been reported in several prior studies on the prediction of VF progression or glaucoma, it has not been addressed in the context of longitudinal VF data. In this work, we proposed, VF-Transformer, a transformer-based framework for VF progression prediction based on longitudinal VF examination results. In particular, we addressed the class imbalance issue by incorporating our proposed inverted class-dependent temperature (ICDT) loss and weight normalization. The proposed framework was developed and evaluated on a public VF dataset and further validated on an external hospital dataset, using accuracy, sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) as evaluation metrics. Extensive experiments and comparisons with existing state-of-the-art methods and class imbalance handling strategies confirmed the effectiveness of the proposed framework in predicting VF progression in the presence of class imbalance.

Personalized medication recommendations aim to suggest a set of medications based on the clinical conditions of a patient. Not only should the patient’s diagnosis, procedure, and medication history be considered, but drug-drug interactions (DDIs) must also be taken into account to prevent adverse drug reactions. Although recent studies on medication recommendation have considered DDIs and patient history, personalized disease progression and prescription have not been explicitly modeled. In this work, we proposed FastRx, a Fastformer-based medication recommendation model to capture longitudinality in patient history, in combination with Graph Convolutional Networks (GCNs) to handle DDIs and co-prescribed medications in Electronic Health Records (EHRs). Our extensive experiments on the MIMIC-III dataset demonstrated superior performance of the proposed FastRx over existing state-of-the-art models for medication recommendation. The source code and data used in the experiments are available at https://github.com/pnmthaoct/FastRx.

General health examination is an integral part of healthcare in many countries. Identifying the participants at risk is important for early warning and preventive intervention. The fundamental challenge of learning a classification model for risk prediction lies in the unlabeled data that constitutes the majority of the collected dataset. Particularly, the unlabeled data describes the participants in health examinations whose health conditions can vary greatly from healthy to very-ill. There is no ground truth for differentiating their states of health. In this paper, we propose a graph-based, semi-supervised learning algorithm called SHG-Health (Semi-supervised Heterogeneous Graph on Health) for risk predictions to classify a progressively developing situation with the majority of the data unlabeled. An efficient iterative algorithm is designed and the proof of convergence is given. Extensive experiments based on both real health examination datasets and synthetic datasets are performed to show the effectiveness and efficiency of our method.

People take regular medical examinations mostly not for discovering diseases but for having a peace of mind regarding their health status. Therefore, it is important to give them an overall feedback with respect to all the health indicators that have been ranked against the whole population. In this paper, we propose a framework of mining Personal Health Index (PHI) from a large and comprehensive geriatric medical examination (GME) dataset. We define PHI as an overall score of personal health status based on a complement probability of health risks. The health risks are calculated using the information from the cause of death (COD) dataset that is linked to the GME dataset. Especially, the highest health risk is revealed in the cases of people who had been taking GME for some years and then passed away for medical reasons. The proposed framework consists of methods in data pre-processing, feature extraction and selection, and model selection. The effectiveness of the proposed framework is validated by a set of comprehensive experiments based on the records of 102,258 participants. As the first of this kind, our work provides a baseline for further research.