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Willem van den Boom

dblp:174/9608 · DBLP profile ↗
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1ranked-venue papers
1as first author
0since 2021 · last 2018
0000-0002-1777-3857ORCID · reported

Domains — the database's venue-derived domains; a paper can count in several

Applied, interdisciplinary, general and emerging computing · 1 · 1 first-author

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
1 paper
Computational science and engineering · 77% Bioinformatics and computational biology · 23%

Topics — the 1 heaviest of 2, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Computational science and engineering
functional data analysis
0.312018
Extrema-weighted feature extraction for functional data · Bioinform. 2018

Methods — techniques the papers use, named apart from their topics

functional regression · 0.3functional classification · 0.3
YearPublicationVenuePosition
2018 Extrema-weighted feature extraction for functional data
abstract
Motivation: Although there is a rich literature on methods for assessing the impact of functional predictors, the focus has been on approaches for dimension reduction that do not suit certain applications. Examples of standard approaches include functional linear models, functional principal components regression and cluster-based approaches, such as latent trajectory analysis. This article is motivated by applications in which the dynamics in a predictor, across times when the value is relatively extreme, are particularly informative about the response. For example, physicians are interested in relating the dynamics of blood pressure changes during surgery to post-surgery adverse outcomes, and it is thought that the dynamics are more important when blood pressure is significantly elevated or lowered. Results: We propose a novel class of extrema-weighted feature (XWF) extraction models. Key components in defining XWFs include the marginal density of the predictor, a function up-weighting values at extreme quantiles of this marginal, and functionals characterizing local dynamics. Algorithms are proposed for fitting of XWF-based regression and classification models, and are compared with current methods for functional predictors in simulations and a blood pressure during surgery application. XWFs find features of intraoperative blood pressure trajectories that are predictive of postoperative mortality. By their nature, most of these features cannot be found by previous methods. Availability and implementation: The R package 'xwf' is available at the CRAN repository: https://cran.r-project.org/package=xwf. Supplementary information: Supplementary data are available at Bioinformatics online.
Willem van den Boom, Callie Mao, Rebecca A. Schroeder, David B. Dunson
Bioinform.1