Inspired by nature, molecular communications (MC), i.e., the use of molecules to encode, transmit, and receive information, stands as the most promising communication paradigm to realize the nanonetworks. Even though there has been extensive theoretical research toward nanoscale MC, there are no examples of implemented nanoscale MC networks. The main reason for this lies in the peculiarities of nanoscale physics, challenges in nanoscale fabrication, and highly stochastic nature of the biochemical domain of envisioned nanonetwork applications. This mandates developing novel device architectures and communication methods compatible with MC constraints. To that end, various transmitter and receiver designs for MC have been proposed in the literature together with numerable modulation, coding, and detection techniques. However, these works fall into domains of a very wide spectrum of disciplines, including, but not limited to, information and communication theory, quantum physics, materials science, nanofabrication, physiology, and synthetic biology. Therefore, we believe it is imperative for the progress of the field that an organized exposition of cumulative knowledge on the subject matter can be compiled. Thus, to fill this gap, in this comprehensive survey, we review the existing literature on transmitter and receiver architectures toward realizing MC among nanomaterial-based nanomachines and/or biological entities and provide a complete overview of modulation, coding, and detection techniques employed for MC. Moreover, we identify the most significant shortcomings and challenges in all these research areas and propose potential solutions to overcome some of them.

Communication among neurons is the highly evolved and efficient nanoscale communication paradigm, hence the most promising technique for biocompatible nanonetworks. This necessitates the understanding of neuro-spike communication from information theoretical perspective to reach a reference model for nanonetworks. This would also contribute towards developing ICT-based diagnostics techniques for neuro-degenerative diseases. Thus, in this paper, we focus on the fundamental building block of neuro-spike communication, i.e., signal transmission over a synapse, to evaluate its information transfer rate. We aim to analyze a realistic synaptic communication model, which for the first time, encompasses the variation in vesicle release probability with time, synaptic geometry and the re-uptake of neurotransmitters by pre-synaptic terminal. To achieve this objective, we formulate the mutual information between input and output of the synapse. Then, since this communication paradigm has memory, we evaluate the average mutual information over multiple transmissions to find its overall capacity. We derive a closed-form expression for the capacity of the synaptic communication as well as calculate the capacity-achieving input probability distribution. Finally, we find the effects of variation in different synaptic parameters on the information capacity and prove that the diffusion process does not decrease the information a neural response carries about the stimulus in real scenario.

Molecular communication (MC) is the most promising communication paradigm for nanonetwork realization since it is a natural phenomenon observed among living entities with nanoscale components. Since MC significantly differs from classical communication systems, it mandates reinvestigation of information and communication theoretical fundamentals. The closest examples of MC architectures are present inside our own body. Therefore, in this paper, we investigate the existing literature on intrabody nanonetworks and different MC paradigms to establish and introduce the fundamentals of molecular information and communication science. We highlight future research directions and open issues that need to be addressed for revealing the fundamental limits of this science. Although the scope of this development encompasses wide range of applications, we particularly emphasize its significance for life sciences by introducing potential diagnosis and treatment techniques for diseases caused by dysfunction of intrabody nanonetworks.

We utilize the well known Additive Inverse Gaussian Noise (AIGN) communication channel to investigate the effect of diversity in diffusion-based molecular communication with drift, where the transmitter releases different types of molecules to the fluid medium by encoding the information onto the release time and type of molecules. The fluid channel imposes extra delay on the communication, and the receiver decodes the encoded information by solely utilizing the molecular arrival times. In this paper, simple receiver models based on maximum likelihood estimation (MLE) are investigated. Furthermore, upper and lower bounds on the capacity of AIGN communication channel with molecular diversity are derived.