In the past five years, deep learning methods have become state-of-the-art in solving various inverse problems. Before such approaches can find application in safety-critical fields, a verification of their reliability appears mandatory. Recent works have pointed out instabilities of deep neural networks for several image reconstruction tasks. In analogy to adversarial attacks in classification, it was shown that slight distortions in the input domain may cause severe artifacts. The present article sheds new light on this concern, by conducting an extensive study of the robustness of deep-learning-based algorithms for solving underdetermined inverse problems. This covers compressed sensing with Gaussian measurements as well as image recovery from Fourier and Radon measurements, including a real-world scenario for magnetic resonance imaging (using the NYU-fastMRI dataset). Our main focus is on computing adversarial perturbations of the measurements that maximize the reconstruction error. A distinctive feature of our approach is the quantitative and qualitative comparison with total-variation minimization, which serves as a provably robust reference method. In contrast to previous findings, our results reveal that standard end-to-end network architectures are not only resilient against statistical noise, but also against adversarial perturbations. All considered networks are trained by common deep learning techniques, without sophisticated defense strategies.

This work is concerned with the following fundamental question in scientific machine learning: Can deep-learning-based methods solve noise-free inverse problems to near-perfect accuracy? Positive evidence is provided for the first time, focusing on a prototypical computed tomography (CT) setup. We demonstrate that an iterative end-to-end network scheme enables reconstructions close to numerical precision, comparable to classical compressed sensing strategies. Our results build on our winning submission to the recent AAPM DL-Sparse-View CT Challenge. Its goal was to identify the state-of-the-art in solving the sparse-view CT inverse problem with data-driven techniques. A specific difficulty of the challenge setup was that the precise forward model remained unknown to the participants. Therefore, a key feature of our approach was to initially estimate the unknown fanbeam geometry in a data-driven calibration step. Apart from an in-depth analysis of our methodology, we also demonstrate its state-of-the-art performance on the open-access real-world dataset LoDoPaB CT.