Image registration of liver dynamic contrast-enhanced computed tomography (DCE-CT) is crucial for diagnosis and image-guided surgical planning of liver cancer. However, intensity variations due to the flow of contrast agents combined with complex spatial motion induced by respiration brings great challenge to existing intensity-based registration methods. To address these problems, we propose a novel structure-aware registration method by incorporating structural information of related organs with segmentation-guided deep registration network. Existing segmentation-guided registration methods only focus on volumetric registration inside the paired organ segmentations, ignoring the inherent attributes of their anatomical structures. In addition, such paired organ segmentations are not always available in DCE-CT images due to the flow of contrast agents. Different from existing segmentation-guided registration methods, our proposed method extracts structural information in hierarchical geometric perspectives of line and surface. Then, according to the extracted structural information, structure-aware constraints are constructed and imposed on the forward and backward deformation field simultaneously. In this way, all available organ segmentations, including unpaired ones, can be fully utilized to avoid the side effect of contrast agent and preserve the topology of organs during registration. Extensive experiments on an in-house liver DCE-CT dataset and a public LiTS dataset show that our proposed method can achieve higher registration accuracy and preserve anatomical structure more effectively than state-of-the-art methods.

Anatomical labeling of head and neck vessels is a vital step for cerebrovascular disease diagnosis. However, it remains challenging to automatically and accurately label vessels in computed tomography angiography (CTA) since head and neck vessels are tortuous, branched, and often spatially close to nearby vasculature. To address these challenges, we propose a novel topology-aware graph network (TaG-Net) for vessel labeling. It combines the advantages of volumetric image segmentation in the voxel space and centerline labeling in the line space, wherein the voxel space provides detailed local appearance information, and line space offers high-level anatomical and topological information of vessels through the vascular graph constructed from centerlines. First, we extract centerlines from the initial vessel segmentation and construct a vascular graph from them. Then, we conduct vascular graph labeling using TaG-Net, in which techniques of topology-preserving sampling, topology-aware feature grouping, and multi-scale vascular graph are designed. After that, the labeled vascular graph is utilized to improve volumetric segmentation via vessel completion. Finally, the head and neck vessels of 18 segments are labeled by assigning centerline labels to the refined segmentation. We have conducted experiments on CTA images of 401 subjects, and experimental results show superior vessel segmentation and labeling of our method compared to other state-of-the-art methods.

Entity Set Expansion (ESE) is the problem that expands a small set of seed entities into a more complete set, entities of which have common traits. As a popular data mining task, ESE has been widely used in many applications, such as dictionary construction, query suggestion and new brand identification. Existing ESE methods mainly utilize text and Web information. That is, the intrinsic relation among entities is inferred from their occurrences in text or Web. With the surge of knowledge graph in recent years, it is possible to extend entities according to their occurrences in knowledge graph. In this paper, we consider the knowledge graph as a heterogeneous information network (HIN) that contains different types of objects and links, and propose a novel method, called MP_ESE, to extend entities in the HIN. The MP_ESE employs meta paths, a relation sequence connecting entities, in HIN to capture the implicit common traits of seed entities. In addition, an automatic meta path generation method, called SMPG, has been designed to exploit the potential relations among entities. Heuristic learning and PU learning methods are employed to learn the weights of extracted meta paths. With these generated and weighted meta paths, the MP_ESE can effectively extend entities. Comprehensive experiments on real datasets show the effectiveness and efficiency of MP_ESE.

Machine Reading Comprehension (MRC), which requires a machine to answer questions given the relevant documents, is an important way to test machines' ability to understand human language.Multiple-choice MRC is one of the most studied tasks in MRC due to the convenience of evaluation and the flexibility of answer format.Post-hoc interpretation aims to explain a trained model and reveal how the model arrives at the prediction.One of the most important interpretation forms is to attribute model decisions to input features.Based on post-hoc interpretation methods, we assess attributions of paragraphs in multiplechoice MRC and improve the model by punishing the illogical attributions.Our method can improve model performance without any external information and model structure change.Furthermore, we also analyze how and why such a self-training method works.

Accurate segmentation of the prostate is a key step in external beam radiation therapy treatments. In this paper, we tackle the challenging task of prostate segmentation in CT images by a two-stage network with 1) the first stage to fast localize, and 2) the second stage to accurately segment the prostate. To precisely segment the prostate in the second stage, we formulate prostate segmentation into a multi-task learning framework, which includes a main task to segment the prostate, and an auxiliary task to delineate the prostate boundary. Here, the second task is applied to provide additional guidance of unclear prostate boundary in CT images. Besides, the conventional multi-task deep networks typically share most of the parameters (i.e., feature representations) across all tasks, which may limit their data fitting ability, as the specificity of different tasks are inevitably ignored. By contrast, we solve them by a hierarchically-fused U-Net structure, namely HF-UNet. The HF-UNet has two complementary branches for two tasks, with the novel proposed attention-based task consistency learning block to communicate at each level between the two decoding branches. Therefore, HF-UNet endows the ability to learn hierarchically the shared representations for different tasks, and preserve the specificity of learned representations for different tasks simultaneously. We did extensive evaluations of the proposed method on a large planning CT image dataset and a benchmark prostate zonal dataset. The experimental results show HF-UNet outperforms the conventional multi-task network architectures and the state-of-the-art methods.

The coronavirus disease (COVID-19) is rapidly spreading all over the world, and has infected more than 1,436,000 people in more than 200 countries and territories as of April 9, 2020. Detecting COVID-19 at early stage is essential to deliver proper healthcare to the patients and also to protect the uninfected population. To this end, we develop a dual-sampling attention network to automatically diagnose COVID-19 from the community acquired pneumonia (CAP) in chest computed tomography (CT). In particular, we propose a novel online attention module with a 3D convolutional network (CNN) to focus on the infection regions in lungs when making decisions of diagnoses. Note that there exists imbalanced distribution of the sizes of the infection regions between COVID-19 and CAP, partially due to fast progress of COVID-19 after symptom onset. Therefore, we develop a dual-sampling strategy to mitigate the imbalanced learning. Our method is evaluated (to our best knowledge) upon the largest multi-center CT data for COVID-19 from 8 hospitals. In the training-validation stage, we collect 2186 CT scans from 1588 patients for a 5-fold cross-validation. In the testing stage, we employ another independent large-scale testing dataset including 2796 CT scans from 2057 patients. Results show that our algorithm can identify the COVID-19 images with the area under the receiver operating characteristic curve (AUC) value of 0.944, accuracy of 87.5%, sensitivity of 86.9%, specificity of 90.1%, and F1-score of 82.0%. With this performance, the proposed algorithm could potentially aid radiologists with COVID-19 diagnosis from CAP, especially in the early stage of the COVID-19 outbreak.

Accurate segmentation of pelvic organs (i.e., prostate, bladder, and rectum) from CT image is crucial for effective prostate cancer radiotherapy. However, it is a challenging task due to: 1) low soft tissue contrast in CT images and 2) large shape and appearance variations of pelvic organs. In this paper, we employ a two-stage deep learning-based method, with a novel distinctive curve-guided fully convolutional network (FCN), to solve the aforementioned challenges. Specifically, the first stage is for fast and robust organ detection in the raw CT images. It is designed as a coarse segmentation network to provide region proposals for three pelvic organs. The second stage is for fine segmentation of each organ, based on the region proposal results. To better identify those indistinguishable pelvic organ boundaries, a novel morphological representation, namely, distinctive curve, is also introduced to help better conduct the precise segmentation. To implement this, in this second stage, a multi-task FCN is initially utilized to learn the distinctive curve and the segmentation map separately and then combine these two tasks to produce accurate segmentation map. The final segmentation results of all three pelvic organs are generated by a weighted max-voting strategy. We have conducted exhaustive experiments on a large and diverse pelvic CT data set for evaluating our proposed method. The experimental results demonstrate that our proposed method is accurate and robust for this challenging segmentation task, by also outperforming the state-of-the-art segmentation methods.

Registration of pelvic CT and MRI is highly desired as it can facilitate effective fusion of two modalities for prostate cancer radiation therapy, i.e., using CT for dose planning and MRI for accurate organ delineation. However, due to the large inter-modality appearance gaps and the high shape/appearance variations of pelvic organs, the pelvic CT/MRI registration is highly challenging. In this paper, we propose a region-adaptive deformable registration method for multi-modal pelvic image registration. Specifically, to handle the large appearance gaps, we first perform both CT-to-MRI and MRI-to-CT image synthesis by multi-target regression forest (MT-RF). Then, to use the complementary anatomical information in the two modalities for steering the registration, we select key points automatically from both modalities and use them together for guiding correspondence detection in the region-adaptive fashion. That is, we mainly use CT to establish correspondences for bone regions, and use MRI to establish correspondences for soft tissue regions. The number of key points is increased gradually during the registration, to hierarchically guide the symmetric estimation of the deformation fields. Experiments for both intra-subject and inter-subject deformable registration show improved performances compared with state-of-the-art multi-modal registration methods, which demonstrate the potentials of our method to be applied for the routine prostate cancer radiation therapy.

Computed tomography (CT) is widely used for dose planning in the radiotherapy of prostate cancer. However, CT has low tissue contrast, thus making manual contouring difficult. In contrast, magnetic resonance (MR) image provides high tissue contrast and is thus ideal for manual contouring. If MR image can be registered to CT image of the same patient, the contouring accuracy of CT could be substantially improved, which could eventually lead to high treatment efficacy. In this paper, we propose a learning-based approach for multimodal image registration. First, to fill the appearance gap between modalities, a structured random forest with auto-context model is learnt to synthesize MRI from CT and vice versa. Then, MRI-to-CT registration is steered in a dual manner of registering images with same appearances, i.e., (1) registering the synthesized CT with CT, and (2) also registering MRI with the synthesized MRI. Next, a dual-core deformation fusion framework is developed to iteratively and effectively combine these two registration results. Experiments on pelvic CT and MR images have shown the improved registration performance by our proposed method, compared with the existing non-learning based registration methods.