Sleep staging is important for monitoring sleep quality and diagnosing sleep-related disorders. Recently, numerous deep learning-based models have been proposed for automatic sleep staging using polysomnography recordings. Most of them are trained and tested on the same labeled datasets which results in poor generalization to unseen target domains. However, they regard the subjects in the target domains as a whole and overlook the individual discrepancies, which limits the model's generalization ability to new patients (i.e., unseen subjects) and plug-and-play applicability in clinics. To address this, we propose a novel Source-Free Unsupervised Individual Domain Adaptation (SF-UIDA) framework for sleep staging, leveraging sequential cross-view contrasting and pseudo-label based fine-tuning. It is actually a two-step subject-specific adaptation scheme, which enables the source model to effectively adapt to newly appeared unlabeled individual without access to the source data. It meets the practical needs in real-world scenarios, where the personalized customization can be plug-and-play applied to new ones. Our framework is applied to three classic sleep staging models and evaluated on three public sleep datasets, achieving the state-of-the-art performance.

Electroencephalography (EEG) is a non-invasive technique to measure and record brain electrical activity, widely used in various BCI and healthcare applications. Early EEG decoding methods rely on supervised learning, limited by specific tasks and datasets, hindering model performance and generalizability. With the success of large language models, there is a growing body of studies focusing on EEG foundation models. However, these studies still leave challenges: Firstly, most of existing EEG foundation models employ full EEG modeling strategy. It models the spatial and temporal dependencies between all EEG patches together, but ignores that the spatial and temporal dependencies are heterogeneous due to the unique structural characteristics of EEG signals. Secondly, existing EEG foundation models have limited generalizability on a wide range of downstream BCI tasks due to varying formats of EEG data, making it challenging to adapt to. To address these challenges, we propose a novel foundation model called CBraMod. Specifically, we devise a criss-cross transformer as the backbone to thoroughly leverage the structural characteristics of EEG signals, which can model spatial and temporal dependencies separately through two parallel attention mechanisms. And we utilize an asymmetric conditional positional encoding scheme which can encode positional information of EEG patches and be easily adapted to the EEG with diverse formats. CBraMod is pre-trained on a very large corpus of EEG through patch-based masked EEG reconstruction. We evaluate CBraMod on up to 10 downstream BCI tasks (12 public datasets). CBraMod achieves the state-of-the-art performance across the wide range of tasks, proving its strong capability and generalizability. The source code is publicly available at https://github.com/wjq-learning/CBraMod.

Electroencephalography (EEG) is a non-invasive brain-computer interface technology used for recording brain electrical activity. It plays an important role in human life and has been widely uesd in real life, including sleep staging, emotion recognition, and motor imagery. However, existing EEG-related models cannot be well applied in practice, especially in clinical settings, where new patients with individual discrepancies appear every day. Such EEG-based model trained on fixed datasets cannot generalize well to the continual flow of numerous unseen subjects in real-world scenarios. This limitation can be addressed through continual learning (CL), wherein the CL model can continuously learn and advance over time. Inspired by CL, we introduce a novel Unsupervised Individual Continual Learning paradigm for handling this issue in practice. We propose the BrainUICL framework, which enables the EEG-based model to continuously adapt to the incoming new subjects. Simultaneously, BrainUICL helps the model absorb new knowledge during each adaptation, thereby advancing its generalization ability for all unseen subjects. The effectiveness of the proposed BrainUICL has been evaluated on three different mainstream EEG tasks. The BrainUICL can effectively balance both the plasticity and stability during CL, achieving better plasticity on new individuals and better stability across all the unseen individuals, which holds significance in a practical setting.

Human brain achieves dynamic stability-plasticity balance through synaptic homeostasis, a self-regulatory mechanism that stabilizes critical memory traces while preserving optimal learning capacities. Inspired by this biological principle, we propose SPICED: a neuromorphic framework that integrates the synaptic homeostasis mechanism for unsupervised continual EEG decoding, particularly addressing practical scenarios where new individuals with inter-individual variability emerge continually. SPICED comprises a novel synaptic network that enables dynamic expansion during continual adaptation through three bio-inspired neural mechanisms: (1) critical memory reactivation, which mimics brain functional specificity, selectively activates task-relevant memories to facilitate adaptation; (2) synaptic consolidation, which strengthens these reactivated critical memory traces and enhances their replay prioritizations for further adaptations and (3) synaptic renormalization, which are periodically triggered to weaken global memory traces to preserve learning capacities. The interplay within synaptic homeostasis dynamically strengthens task-discriminative memory traces and weakens detrimental memories. By integrating these mechanisms with continual learning system, SPICED preferentially replays task-discriminative memory traces that exhibit strong associations with newly emerging individuals, thereby achieving robust adaptations. Meanwhile, SPICED effectively mitigates catastrophic forgetting by suppressing the replay prioritization of detrimental memories during long-term continual learning. Validated on three EEG datasets, SPICED show its effectiveness. More importantly, SPICED bridges biological neural mechanisms and artificial intelligence through synaptic homeostasis, providing insights into the broader applicability of bio-inspired principles.

Automatic sleep staging is essential for sleep assessment and disorder diagnosis. Most existing methods depend on one specific dataset and are limited to be generalized to other unseen datasets, for which the training data and testing data are from the same dataset. In this paper, we introduce domain generalization into automatic sleep staging and propose the task of generalizable sleep staging which aims to improve the model generalization ability to unseen datasets. Inspired by existing domain generalization methods, we adopt the feature alignment idea and propose a framework called SleepDG to solve it. Considering both of local salient features and sequential features are important for sleep staging, we propose a Multi-level Feature Alignment combining epoch-level and sequence-level feature alignment to learn domain-invariant feature representations. Specifically, we design an Epoch-level Feature Alignment to align the feature distribution of each single sleep epoch among different domains, and a Sequence-level Feature Alignment to minimize the discrepancy of sequential features among different domains. SleepDG is validated on five public datasets, achieving the state-of-the-art performance.

Sleep staging is essential for sleep assessment and plays an important role in disease diagnosis, which refers to the classification of sleep epochs into different sleep stages. Polysomnography (PSG), consisting of many different physiological signals, e.g. electroencephalogram (EEG) and electrooculogram (EOG), is a gold standard for sleep staging. Although existing studies have achieved high performance on automatic sleep staging from PSG, there are still some limitations: 1) they focus on local features but ignore global features within each sleep epoch, and 2) they ignore cross-modality context relationship between EEG and EOG. In this paper, we propose CareSleepNet, a novel hybrid deep learning network for automatic sleep staging from PSG recordings. Specifically, we first design a multi-scale Convolutional-Transformer Epoch Encoder to encode both local salient wave features and global features within each sleep epoch. Then, we devise a Cross-Modality Context Encoder based on co-attention mechanism to model cross-modality context relationship between different modalities. Next, we use a Transformer-based Sequence Encoder to capture the sequential relationship among sleep epochs. Finally, the learned feature representations are fed into an epoch-level classifier to determine the sleep stages. We collected a private sleep dataset, SSND, and use two public datasets, Sleep-EDF-153 and ISRUC to evaluate the performance of CareSleepNet. The experiment results show that our CareSleepNet achieves the state-of-the-art performance on the three datasets. Moreover, we conduct ablation studies and attention visualizations to prove the effectiveness of each module and to analyze the influence of each modality.

Sarcasm is important to sentiment analysis on social media.Sarcasm Target Identification (STI) deserves further study to understand sarcasm in depth.However, text lacking context or missing sarcasm target makes target identification very difficult.In this paper, we introduce multimodality to STI and present Multimodal Sarcasm Target Identification (MSTI) task.We propose a novel multi-scale crossmodality model that can simultaneously perform textual target labeling and visual target detection.In the model, we extract multi-scale visual features to enrich spatial information for different sized visual sarcasm targets.We design a set of convolution networks to unify multi-scale visual features with textual features for cross-modal attention learning, and correspondingly a set of transposed convolution networks to restore multi-scale visual information.The results show that visual clues can improve the performance of TSTI by a large margin, and VSTI achieves good accuracy.

Recently multimodal named entity recognition (MNER) has utilized images to improve the accuracy of NER in tweets. However, most of the multimodal methods use attention mechanisms to extract visual clues regardless of whether the text and image are relevant. Practically, the irrelevant text-image pairs account for a large proportion in tweets. The visual clues that are unrelated to the texts will exert uncertain or even negative effects on multimodal model learning. In this paper, we introduce a method of text-image relation propagation into the multimodal BERT model. We integrate soft or hard gates to select visual clues and propose a multitask algorithm to train and validate the effects of relation propagation on the MNER datasets. In the experiments, we deeply analyze the changes in visual attention before and after the use of relation propagation. Our model achieves state-of-the-art performance on the MNER datasets.

Multimodal named entity recognition (MNER) for tweets has received increasing attention recently.Most of the multimodal methods used attention mechanisms to capture the text-related visual information.However, unrelated or weakly related text-image pairs account for a large proportion in tweets.Visual clues unrelated to the text would incur uncertain or even negative effects for multimodal model learning.In this paper, we propose a novel pre-trained multimodal model based on Relationship Inference and Visual Attention (RIVA) for tweets.The RIVA model controls the attention-based visual clues with a gate regarding the role of image to the semantics of text.We use a teacher-student semi-supervised paradigm to leverage a large unlabeled multimodal tweet corpus with a labeled data set for text-image relation classification.In the multimodal NER task, the experimental results show the significance of text-related visual features for the visual-linguistic model and our approach achieves SOTA performance on the MNER datasets.

PURPOSE: We explored the mechanism of aspirin in SCLC by dissecting many publicly available databases. METHODS AND RESULTS: Firstly, 11 direct protein targets (DPTs) of aspirin were identified by DrugBank 5.0. Then protein-protein interaction (PPI) network and signaling pathways of aspirin DPTs were analyzed. We found that aspirin was linked with many kinds of cancer, and the most significant one is SCLC. Next, we classified the mutation of 4 aspirin DPTs in SCLC (IKBKB, NFKBIA, PTGS2 and TP53) using cBio Portal. Further, we identified top 50 overexpressed genes of SCLC by Oncomine, and the interconnected genes with the 4 aspirin DPTs in SCLC (IKBKB, NFKBIA, PTGS2 and TP53) by STRING. Lastly, we figured out 5 consistently genes as potential therapeutic targets of aspirin in SCLC. CONCLUSION: The integrated bioinformatical analysis could improve our understanding of the underlying molecular mechanism about how aspirin working in SCLC. Integrated bioinformatical analysis may be considered as a new paradigm for guiding future studies about interaction in drugs and diseases.