Identifying informative predictors in a high-dimensional regression model is a critical step for association analysis and predictive modeling. Signal detection in the high dimensional setting often fails due to the limited sample size. One approach to improving power is through meta-analyzing multiple studies which address the same scientific question. However, integrative analysis of high dimensional data from multiple studies is challenging in the presence of between-study heterogeneity. The challenge is even more pronounced with additional data sharing constraints under which only summary data can be shared across different sites. In this paper, we propose a novel data shielding integrative large--scale testing (DSILT) approach to signal detection allowing between-study heterogeneity and not requiring the sharing of individual-level data. Assuming the underlying high dimensional regression models of the data differ across studies yet share similar support, the proposed method incorporates proper integrative estimation and debiasing procedures to construct test statistics for the overall effects of specific covariates. We also develop a multiple testing procedure to identify significant effects while controlling the false discovery rate (FDR) and false discovery proportion (FDP). Theoretical comparisons of the new testing procedure with the ideal individual-level meta-analysis (ILMA) approach and other distributed inference methods are investigated. Simulation studies demonstrate that the proposed testing procedure performs well in both controlling false discovery and attaining power. The new method is applied to a real example detecting interaction effects of the genetic variants for statins and obesity on the risk for type II diabetes.

Existing methods on video-based action recognition are generally view-dependent, i.e., performing recognition from the same views seen in the training data. We present a novel multiview spatio-temporal and-or graph (MST-AOG) representation for cross-view action recognition, i.e., the recognition is performed on the video from an unknown and unseen view. As a compositional model, MST-AOG compactly represents the hierarchical combinatorial structures of cross-view actions by explicitly modeling the geometry, appearance and motion variations. This paper proposes effective methods to learn the structure and parameters of MST-AOG. The inference based on MST-AOG enables action recognition from novel views. The training of MST-AOG takes advantage of the 3D human skeleton data obtained from Kinect cameras to avoid annotating enormous multi-view video frames, which is error-prone and time-consuming, but the recognition does not need 3D information and is based on 2D video input. A new Multiview Action3D dataset has been created and will be released. Extensive experiments have demonstrated that this new action representation significantly improves the accuracy and robustness for cross-view action recognition on 2D videos.

This paper presents a novel approach to cross-view action recognition. Traditional cross-view action recognition methods typically rely on local appearance/motion features. In this paper, we take advantage of the recent developments of depth cameras to build a more discriminative cross-view action representation. In this representation, an action is characterized by the spatio-temporal configuration of 3D Poselets, which are discriminatively discovered with a novel Poselet mining algorithm and can be detected with view-invariant 3D Poselet detectors. The Kinect skeleton is employed to facilitate the 3D Poselet mining and 3D Poselet detectors learning, but the recognition is solely based on 2D video input. Extensive experiments have demonstrated that this new action representation significantly improves the accuracy and robustness for cross-view action recognition.