Addressing both natural and societal challenges requires collective cooperation. Studies on collective-risk social dilemmas have shown that individual decisions are influenced by the perceived risk of collective failure. However, existing feedback-evolving game models often focus on a single feedback mechanism, such as the coupling between cooperation and risk or between cooperation and cost. In many real-world scenarios, however, the level of cooperation, the cost of cooperating, and the collective risk are dynamically interlinked. Here, we present an evolutionary game model that considers the interplay of these three variables. Our analysis shows that the worst-case scenario, characterized by full defection, maximum risk, and the highest cost of cooperation, remains a stable evolutionary attractor. Nevertheless, cooperation can emerge and persist because the system also supports stable equilibria with non-zero cooperation. The system exhibits multistability, meaning that different initial conditions lead to either sustained cooperation or a tragedy of the commons. These findings highlight that initial levels of cooperation, cost, and risk collectively determine whether a population can avert a tragic outcome.

We introduce Agentic Reasoning, a framework that enhances large language model (LLM) reasoning by integrating external tool-using agents.Agentic Reasoning dynamically leverages web search, code execution, and structured memory to address complex problems requiring deep research.A key innovation in our framework is the Mind-Map agent, which constructs a structured knowledge graph to store reasoning context and track logical relationships, ensuring coherence in long reasoning chains with extensive tool usage.Additionally, we conduct a comprehensive exploration of the Web-Search agent, leading to a highly effective search mechanism that surpasses all prior approaches.When deployed on DeepSeek-R1, our method achieves a new state-of-the-art (SOTA) among public models and delivers performance comparable to OpenAI Deep Research, the leading proprietary model in this domain.Extensive ablation studies validate the optimal selection of agentic tools and confirm the effectiveness of our Mind-Map and Web-Search agents in enhancing LLM reasoning.Our code and data are publicly available.

The severe shortage of medical doctors limits access to timely and reliable healthcare, leaving millions underserved. Large language models (LLMs) offer a potential solution but struggle in real-world clinical interactions. Many LLMs are not grounded in authoritative medical guidelines and fail to transparently manage diagnostic uncertainty. Their language is often rigid and mechanical, lacking the human-like qualities essential for patient trust. To address these challenges, we propose Ask Patients with Patience (APP), a multi-turn LLM-based medical assistant designed for grounded reasoning, transparent diagnoses, and human-centric interaction. APP enhances communication by eliciting user symptoms through empathetic dialogue, significantly improving accessibility and user engagement. It also incorporates Bayesian active learning to support transparent and adaptive diagnoses. The framework is built on verified medical guidelines, ensuring clinically grounded and evidence-based reasoning. To evaluate its performance, we develop a new benchmark that simulates realistic medical conversations using patient agents driven by profiles extracted from real-world consultation cases. We compare APP against SOTA one-shot and multi-turn LLM baselines. The results show that APP improves diagnostic accuracy, reduces uncertainty, and enhances user experience. By integrating medical expertise with transparent, human-like interaction, APP bridges the gap between AI-driven medical assistance and real-world clinical practice.

Prototypical-part methods, e.g., ProtoPNet, enhance interpretability in image recognition by linking predictions to training prototypes, thereby offering intuitive insights into their decision-making. Existing methods, which rely on a point-based learning of prototypes, typically face two critical issues: 1) the learned prototypes have limited representation power and are not suitable to detect Out-of-Distribution (OoD) inputs, reducing their decision trustworthiness; and 2) the necessary projection of the learned prototypes back into the space of training images causes a drastic degradation in the predictive performance. Furthermore, current prototype learning adopts an aggressive approach that considers only the most active object parts during training, while overlooking sub-salient object regions which still hold crucial classification information. In this paper, we present a new generative paradigm to learn prototype distributions, termed as Mixture of Gaussian-distributed Prototypes (MGProto). The distribution of prototypes from MGProto enables both interpretable image classification and trustworthy recognition of OoD inputs. The optimisation of MGProto naturally projects the learned prototype distributions back into the training image space, thereby addressing the performance degradation caused by prototype projection. Additionally, we develop a novel and effective prototype mining strategy that considers not only the most active but also sub-salient object parts. To promote model compactness, we further propose to prune MGProto by removing prototypes with low importance priors. Experiments on CUB-200-2011, Stanford Cars, Stanford Dogs, and Oxford-IIIT Pets datasets show that MGProto achieves state-of-the-art image recognition and OoD detection performances, while providing encouraging interpretability results.

Secure healthcare information exchange (HIE) is critical to improving medical services, enabling data interoperability, and ensuring patient privacy. However, the increasing threat posed by quantum computing challenges the reliability of conventional cryptographic mechanisms. To address this, we propose a post-quantum secure healthcare data-sharing scheme that combines the Extended Merkle Signature Scheme (XMSS) and consortium blockchain technology to guarantee the integrity, authenticity, and traceability of electronic medical records (EMRs). Furthermore, the scheme incorporates autonomous artificial intelligence (AI) to assist healthcare professionals in generating accurate and intelligent diagnostic reports, enhancing clinical decision-making. We theoretically analyze the scheme's security in the random oracle model, demonstrating that it effectively resists various threats. Performance evaluation shows that the scheme is particularly suitable for HIE scenarios as it reduces about 49% in total computational overheads and 36% in blockchain storage compared to other schemes.

3D medical image segmentation methods have been successful, but their dependence on large amounts of voxel-level annotated data is a disadvantage that needs to be addressed given the high cost to obtain such annotation. Semi-supervised learning (SSL) solves this issue by training models with a large unlabelled and a small labelled dataset. The most successful SSL approaches are based on consistency learning that minimises the distance between model responses obtained from perturbed views of the unlabelled data. These perturbations usually keep the spatial input context between views fairly consistent, which may cause the model to learn segmentation patterns from the spatial input contexts instead of the foreground objects. In this paper, we introduce the Translation Consistent Co-training (TraCoCo) which is a consistency learning SSL method that perturbs the input data views by varying their spatial input context, allowing the model to learn segmentation patterns from foreground objects. Furthermore, we propose a new Confident Regional Cross entropy (CRC) loss, which improves training convergence and keeps the robustness to co-training pseudo-labelling mistakes. Our method yields state-of-the-art (SOTA) results for several 3D data benchmarks, such as the Left Atrium (LA), Pancreas-CT (Pancreas), and Brain Tumor Segmentation (BraTS19). Our method also attains best results on a 2D-slice benchmark, namely the Automated Cardiac Diagnosis Challenge (ACDC), further demonstrating its effectiveness. Our code, training logs and checkpoints are available at https://github.com/yyliu01/ TraCoCo.

Audio-visual segmentation (AVS) is a challenging task that involves accurately segmenting sounding objects based on audio-visual cues. The effectiveness of audio-visual learning critically depends on achieving accurate cross-modal alignment between sound and visual objects. Successful audio-visual learning requires two essential components: 1) a challenging dataset with high-quality pixel-level multiclass annotated images associated with audio files, and 2) a model that can establish strong links between audio information and its corresponding visual object. However, these requirements are only partially addressed by current methods, with training sets containing biased audio-visual data, and models that generalise poorly beyond this biased training set. In this work, we propose a new cost-effective strategy to build challenging and relatively unbiased high-quality audio-visual segmentation benchmarks. We also propose a new informative sample mining method for audio-visual supervised contrastive learning to leverage discriminative contrastive samples to enforce cross-modal understanding. We show empirical results that demonstrate the effectiveness of our benchmark. Furthermore, experiments conducted on existing AVS datasets and on our new benchmark show that our method achieves state-of-the-art (SOTA) segmentation accuracy11This work was supported by Australian Research Council through grant FT190100525.

Deep learning methods have shown outstanding classification accuracy in medical imaging problems, which is largely attributed to the availability of large-scale datasets manually annotated with clean labels. However, given the high cost of such manual annotation, new medical imaging classification problems may need to rely on machine-generated noisy labels extracted from radiology reports. Indeed, many Chest X-Ray (CXR) classifiers have been modelled from datasets with noisy labels, but their training procedure is in general not robust to noisy-label samples, leading to sub-optimal models. Furthermore, CXR datasets are mostly multi-label, so current multi-class noisy-label learning methods cannot be easily adapted. In this paper, we propose a new method designed for noisy multi-label CXR learning, which detects and smoothly re-labels noisy samples from the dataset to be used in the training of common multi-label classifiers. The proposed method optimises a bag of multi-label descriptors (BoMD) to promote their similarity with the semantic descriptors produced by language models from multi-label image annotations. Our experiments on noisy multi-label training sets and clean testing sets show that our model has state-of-the-art accuracy and robustness in many CXR multi-label classification benchmarks, including a new benchmark that we propose to systematically assess noisy multi-label methods. Code is available at https://github.com/cyh-0/BoMD.

Semantic segmentation models classify pixels into a set of known ("in-distribution") visual classes. When deployed in an open world, the reliability of these models depends on their ability to not only classify in-distribution pixels but also to detect out-of-distribution (OoD) pixels. Historically, the poor OoD detection performance of these models has motivated the design of methods based on model re-training using synthetic training images that include OoD visual objects. Although successful, these re-trained methods have two issues: 1) their in-distribution segmentation accuracy may drop during re-training, and 2) their OoD detection accuracy does not generalise well to new contexts outside the training set (e.g., from city to country context). In this paper, we mitigate these issues with: (i) a new residual pattern learning (RPL) module that assists the segmentation model to detect OoD pixels with minimal deterioration to inlier segmentation accuracy; and (ii) a novel context-robust contrastive learning (CoroCL) that enforces RPL to robustly detect OoD pixels in various contexts. Our approach improves by around 10% FPR and 7% AuPRC previous state-of-the-art in Fishyscapes, Segment-Me-If-You-Can, and RoadAnomaly datasets.

Prototypical part network (ProtoPNet) methods have been designed to achieve interpretable classification by associating predictions with a set of training prototypes, which we refer to as trivial prototypes because they are trained to lie far from the classification boundary in the feature space. Note that it is possible to make an analogy between ProtoPNet and support vector machine (SVM) given that the classification from both methods relies on computing similarity with a set of training points (i.e., trivial prototypes in ProtoPNet, and support vectors in SVM). However, while trivial prototypes are located far from the classification boundary, support vectors are located close to this boundary, and we argue that this discrepancy with the well-established SVM theory can result in ProtoPNet models with inferior classification accuracy. In this paper, we aim to improve the classification of ProtoPNet with a new method to learn support prototypes that lie near the classification boundary in the feature space, as suggested by the SVM theory. In addition, we target the improvement of classification results with a new model, named ST-ProtoPNet, which exploits our support prototypes and the trivial prototypes to provide more effective classification. Experimental results on CUB-200-2011, Stanford Cars, and Stan-ford Dogs datasets demonstrate that ST-ProtoPNet achieves state-of-the-art classification accuracy and interpretability results. We also show that the proposed support prototypes tend to be better localised in the object of interest rather than in the background region.

Consistency learning using input image, feature, or network perturbations has shown remarkable results in semi-supervised semantic segmentation, but this approach can be seriously affected by inaccurate predictions of unlabelled training images. There are two consequences of these inaccurate predictions: 1) the training based on the “strict” cross-entropy (CE) loss can easily overfit prediction mistakes, leading to confirmation bias; and 2) the perturbations applied to these inaccurate predictions will use potentially erroneous predictions as training signals, degrading consistency learning. In this paper, we address the prediction accuracy problem of consistency learning methods with novel extensions of the mean-teacher (MT) model, which include a new auxiliary teacher, and the replacement of MT's mean square error (MSE) by a stricter confidence-weighted cross-entropy (Conf-CE) loss. The accurate prediction by this model allows us to use a challenging combination of network, input data and feature perturbations to improve the consistency learning generalisation, where the feature perturbations consist of a new adversarial perturbation. Results on public benchmarks show that our approach achieves remarkable improvements over the previous SOTA methods in the field.11Supported by Australian Research Council through grants DP180103232 and FT190100525. Our code is available at https://github.com/yyliu01/PS-MT.

Effective semi-supervised learning (SSL) in medical image analysis (MIA) must address two challenges: 1) work effectively on both multi-class (e.g., lesion classification) and multi-label (e.g., multiple-disease diagnosis) problems, and 2) handle imbalanced learning (because of the high variance in disease prevalence). One strategy to explore in SSL MIA is based on the pseudo labelling strategy, but it has a few shortcomings. Pseudo-labelling has in general lower accuracy than consistency learning, it is not specifically design for both multi-class and multi-label problems, and it can be challenged by imbalanced learning. In this paper, unlike traditional methods that select confident pseudo label by threshold, we propose a new SSL algorithm, called anti-curriculum pseudo-labelling (ACPL), which introduces novel techniques to select informative unlabelled samples, improving training balance and allowing the model to work for both multi-label and multi-class problems, and to estimate pseudo labels by an accurate ensemble of classifiers (improving pseudo label accuracy). We run extensive experiments to evaluate ACPL on two public medical image classification benchmarks: Chest X-Ray 14 for thorax disease multi-label classification and ISIC2018 for skin lesion multi-class classification. Our method outperforms previous SOTA SSL methods on both datasets11Supported by Australian Research Council through grants DP180103232 and FT190100525.22Code is available at https://github.com/FBLADL/ACPL.