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Katherine Z. Liu

dblp:185/8274 · DBLP profile ↗
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1ranked-venue papers
0as first author
0since 2021 · last 2016
—ORCID · none

Domains — the database's venue-derived domains; a paper can count in several

Applied, interdisciplinary, general and emerging computing · 1

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
1 paper
Bioinformatics and computational biology · 100%
Databases, data mining, and information retrieval
1 paper
Data mining · 100%

Topics — the 3 heaviest of 3, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Bioinformatics and computational biology › population genetics
ancestry inference
0.212016
pong: fast analysis and visualization of latent clusters in population genetic data · Bioinform. 2016
Bioinformatics and computational biology
population genetics
0.212016
pong: fast analysis and visualization of latent clusters in population genetic data · Bioinform. 2016
Data mining
clustering
0.112016
pong: fast analysis and visualization of latent clusters in population genetic data · Bioinform. 2016

Methods — techniques the papers use, named apart from their topics

network-graphical visualization · 0.5assignment problem algorithms · 0.5
YearPublicationVenuePosition
2016 pong: fast analysis and visualization of latent clusters in population genetic data
abstract
MOTIVATION: A series of methods in population genetics use multilocus genotype data to assign individuals membership in latent clusters. These methods belong to a broad class of mixed-membership models, such as latent Dirichlet allocation used to analyze text corpora. Inference from mixed-membership models can produce different output matrices when repeatedly applied to the same inputs, and the number of latent clusters is a parameter that is often varied in the analysis pipeline. For these reasons, quantifying, visualizing, and annotating the output from mixed-membership models are bottlenecks for investigators across multiple disciplines from ecology to text data mining. RESULTS: We introduce pong, a network-graphical approach for analyzing and visualizing membership in latent clusters with a native interactive D3.js visualization. pong leverages efficient algorithms for solving the Assignment Problem to dramatically reduce runtime while increasing accuracy compared with other methods that process output from mixed-membership models. We apply pong to 225 705 unlinked genome-wide single-nucleotide variants from 2426 unrelated individuals in the 1000 Genomes Project, and identify previously overlooked aspects of global human population structure. We show that pong outpaces current solutions by more than an order of magnitude in runtime while providing a customizable and interactive visualization of population structure that is more accurate than those produced by current tools. AVAILABILITY AND IMPLEMENTATION: pong is freely available and can be installed using the Python package management system pip. pong's source code is available at https://github.com/abehr/pong CONTACT: [email protected] or [email protected] SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Aaron A. Behr, Katherine Z. Liu, Gracie Liu-Fang, Priyanka Nakka, Sohini Ramachandran
Bioinform.2