Scientific image manipulation in biomedical publications poses a growing threat to research integrity and reproducibility. Unlike natural image forensics, biomedical forgery detection is uniquely challenging due to domain-specific artifacts, complex textures, and unstructured figure layouts. We present the first vision-language guided framework for both generating and detecting biomedical image forgeries. By combining diffusion-based synthesis with vision-language prompting, our method enables realistic and semantically controlled manipulations—including duplication, splicing, and region removal—across diverse biomedical modalities. We introduce Rescind, a large-scale benchmark featuring fine-grained annotations and modality-specific splits, and propose Integscan, a structured state-space modeling framework that integrates attention-enhanced visual encoding with prompt-conditioned semantic alignment for precise forgery localization. To ensure semantic fidelity, we incorporate a VLM-based verification loop that filters generated forgeries based on consistency with intended prompts. Extensive experiments on Rescind and existing benchmarks demonstrate that Integscan achieves state-of-the-art performance in both detection and localization, establishing a strong foundation for automated scientific integrity analysis.

We introduce Forensim, an attention-based state-space framework for image forgery detection that jointly local-izes both manipulated (target) and source regions. Unlike traditional approaches that rely solely on artifact cues to detect spliced or forged areas, Forensim is designed to capture duplication patterns crucial for understanding context. In scenarios like protest imagery, detecting only the forged region—e.g., a duplicated act of violence inserted into a peaceful crowd—can mislead interpretation, highlighting the need for joint source-target localization. Forensim outputs three-class masks (pristine, source, target) and supports detection of both splicing and copy-move forgeries within a unified architecture. We propose a visual state-space model that leverages normalized attention maps to identify internal similarities, paired with a region-based block-attention module to distinguish manipulated regions. This design enables end-to-end training and precise localization. Forensim achieves state-of-the-art performance on standard benchmarks. We also release CMFD Anything, a new dataset addressing limitations of existing copy-move forgery datasets. Project page and code.

Manipulation of biomedical images to misrepresent experimental results has plagued the biomedical community for a while. Recent interest in the problem led to the curation of a dataset and associated tasks to promote the development of biomedical forensic methods. Of these, the largest manipulation detection task focuses on the detection of duplicated regions between images. Traditional computer-vision based forensic models trained on natural images are not designed to overcome the challenges presented by biomedical images. We propose a multi-scale overlap detection model to detect duplicated image regions. Our model is structured to find duplication hierarchically, so as to reduce the number of patch operations. It achieves state-of-the-art performance overall and on multiple biomedical image categories.

Unlike conventional zero-shot classification, zero-shot semantic segmentation predicts a class label at the pixel level instead of the image level. When solving zero-shot semantic segmentation problems, the need for pixel-level prediction with surrounding context motivates us to incorporate spatial information using positional encoding. We improve standard positional encoding by introducing the concept of Relative Positional Encoding, which integrates spatial information at the feature level and can handle arbitrary image sizes. Furthermore, while self-training is widely used in zero-shot semantic segmentation to generate pseudo-labels, we propose a new knowledge-distillation-inspired self-training strategy, namely Annealed Self-Training, which can automatically assign different importance to pseudo-labels to improve performance. We systematically study the proposed Relative Positional Encoding and Annealed Self-Training in a comprehensive experimental evaluation, and our empirical results confirm the effectiveness of our method on three benchmark datasets.

Research in media forensics has gained traction to combat the spread of misinformation. However, most of this research has been directed towards content generated on social media. Biomedical image forensics is a related problem, where manipulation or misuse of images reported in biomedical research documents is of serious concern. The problem has failed to gain momentum beyond an academic discussion due to an absence of benchmark datasets and standardized tasks. In this paper we present BioFors1– the first dataset for benchmarking common biomedical image manipulations. BioFors comprises 47,805 images extracted from 1,031 open-source research papers. Images in BioFors are divided into four categories – Microscopy, Blot/Gel, FACS and Macroscopy. We also propose three tasks for forensic analysis – external duplication detection, internal duplication detection and cut/sharp-transition detection. We benchmark BioFors on all tasks with suitable state-of-the-art algorithms. Our results and analysis show that existing algorithms developed on common computer vision datasets are not robust when applied to biomedical images, validating that more research is required to address the unique challenges of biomedical image forensics.

Object detection and tracking is an important research topic in computer vision with numerous practical applications. Although great progress has been made both in object detection and tracking, it is still a big challenge in automatic real-time applications. In this paper, a fast and robust approach is proposed by integrating an adaptive object detection technique within a kernelized correlation filter (KCF) framework. The KCF tracker is automatically initialized via salient object detection and localization. An adaptive object detection strategy is proposed to refine the location and boundary of the object when the tracking confidence value is below a certain threshold. In addition, a reliable post-processing technique is designed to accurately localize the object from a saliency map. Extensive quantitative and qualitative experiments on the challenging datasets have been performed to verify the proposed approach, which also demonstrates that our approach greatly outperforms the state-of-the-art methods in terms of tracking speed and accuracy.