BACKGROUND: Accumulating evidence demonstrates that microRNA (miRNA) dysregulation drives the pathogenesis of diverse human diseases via intricate, context-dependent molecular mechanisms. Hence, prediction of miRNA-disease association types is a critical prerequisite for dissecting functional roles of miRNAs in disease initiation and progression. Although computational methods offer cost-effective, time-efficient alternatives to wet-lab experiments for miRNA-disease association type prediction, most of them are hampered by three key limitations: excessive reliance on association-derived similarity metrics gives rise to quantification bias, traditional pairwise graph architectures inadequately capture high-order biological interactions, and existing representation learning strategies fail to generate consistent embeddings across heterogeneous views and modalities. RESULTS: To address these issues, this study presents DHGCMDA, a dual-view heterogeneous graph contrastive learning framework for miRNA-disease association type prediction. Specifically, dual-view hypergraphs are first constructed based on heterogeneous similarity data to avoid excessive reliance on association-derived similarity metrics. A hypergraph convolutional network is then employed to capture high-order topological relationships between miRNAs and diseases, with its convolution cooperatively integrated with contrastive learning, intra-modality for cross-view consistency and cross-modality for embedding space alignment, to enhance feature representation quality. Finally, an attention-guided adaptive view fusion strategy dynamically weights and integrates distinct view representations, and type-aware message passing via heterogeneous graph Transformer simultaneously enables prediction of association presence and functional types. 5-fold cross-validation on HMDD v2.0 and v3.2 datasets demonstrates that DHGCMDA outperforms several state-of-the-art methods. Furthermore, case studies on breast neoplasms and hepatocellular carcinoma reveal that most predicted association types are corroborated by published literature, thereby validating the efficacy of DHGCMDA in miRNA-disease association type prediction. CONCLUSIONS: DHGCMDA exhibits robust discriminative power and generalization capability, providing a reliable computational alternative for miRNA-disease association type prediction. The source code is publicly available at https://github.com/CDMBlab/DHGCMDA .

Simultaneous Localization and Mapping (SLAM) has become a critical technology for intelligent transportation systems and autonomous robots and is widely used in autonomous driving. However, traditional manual feature-based methods in challenging lighting environments make it difficult to ensure robustness and accuracy. Some deep learning-based methods show potential but still have significant drawbacks. To address this problem, we propose a feature-based visual SLAM system based on the LightGlue deep learning network. It uses deep local feature descriptors to replace traditional hand-crafted features and a more efficient and accurate deep network to achieve fast and precise feature matching. Thus, we use the robustness of deep learning to improve the whole system. We have combined traditional geometry-based approaches to introduce a complete visual SLAM system for monocular, binocular, and RGB-D sensors. We thoroughly tested the proposed system on four public datasets: KITTI, EuRoC, TUM, and 4Season, as well as on actual campus scenes. The experimental results show that the proposed method exhibits better accuracy and robustness in adapting to low-light and strongly light-varying environments than traditional manual features and deep learning-based methods. It can also run on GPU in real time.

Community detection has attracted growing interest, with multi-objective evolutionary algorithms proving to be highly competitive in this area. In this paper, a community detection method based on a multi-objective neighborhood coevolution genetic algorithm, NCMOGA, is proposed. To improve the computational efficiency in large-scale networks, NCMOGA introduces a network processing strategy to simplify the network before and during evolution. A neighborhood coevolution strategy is proposed, in which the corresponding subpopulation is formed according to the neighborhood of each individual. A series of operations such as crossover, mutation and update are performed in the subpopulation, emphasizing the synergy between individuals and their neighbors. Mating selection and crossover operations are performed based on the center selection idea of density peak clustering, and the most important nodes are selected to generate offspring. The effectiveness of NCMOGA is verified on synthetic networks and real-world networks. In addition, the results in guiding the classification of disease and healthy samples demonstrate the high quality of the modules detected by NCMOGA.

Remote sensing object detection has flourished at a rapid rate of development. In remote sensing images (RSI), most algorithms perform well in detecting medium and large objects but perform poorly on small objects. This is because small objects occupy fewer pixels in the entire image, and the detector is more likely to be biased towards detecting large objects. In addition, the huge background in the image also introduces noise, causing many detection failures. Most approaches solve the problem of small object detection by increasing the depth of the neural network, but the results are not satisfactory. To solve the above problems, we propose a new method, MF-YOLO, that utilizes fused infrared (IR) and red-green-blue (RGB) images for remote sensing object detection. Through multimodal fusion (MF), we can obtain more positive information, thereby improving detection accuracy. In addition, we introduced the Bi-Level Routing Attention (BRA) module to improve the YOLOv5s model structure, and proposed a new loss function to enhance the model’s learning discrimination ability. Experimental results show that the accuracy of MF-YOLO on the VEDAI and NWPU VHR-10 datasets is 76.62% and 91.63% respectively (in terms of [email protected]). Compared with the existing state-of-the-art, the detection accuracy is significantly improved. In addition, our model has fewer weight parameters than YOLOv5s, allowing it to achieve relatively high near-real-time detection speed.

Steel surface defect detection is very important in industrial quality inspection, and there have been many studies on Steel surface defect detection in recent years. Existing steel surface defect detection algorithms suffer from low detection accuracy and high model complexity. To improve the above problems, this paper proposes an optimized target detection algorithm based on YOLOv5. Firstly, the original spatial pyramid pooling (SPP) module is replaced by the SPPFCSPC module to better capture the target and scene information at different scales, and to improve the sensory field and feature expression ability of the model. Secondly, we propose the C2F-Faster module based on FasterNet and C2F module to replace the C3 module of the backbone network, which perfectly integrates the ideas of PConv and ELAN and ensures the detection accuracy while effectively reducing the model size. Finally, the Dynamic Head detection head is fused in the head of the model to improve the detection capability of the target detection head using the separated attention mechanism. We conducted experimental validation on the widely used NEU-DET dataset. The experimental results show that the improved model improves the original YOLOv5 model over the original YOLOv5 model by 3.6% in mAP@50, 9.9% and 2.8% in AP and AR, respectively, and the amount of model parameters is reduced by 13.2%. The improved model also outperforms SSD, FasterRCNN, YOLOv5, YOLOv6, YOLOv7, YOLOv8 and other mainstream target detection models, which better meets the requirements of actual industrial production on the accuracy and speed of steel surface defects detection model.

PCB defect detection is a typical small objects detection task, as with other objects, there is a small object size, the detection process is susceptible to the problem of background interference. In practical industrial production, it is difficult for existing object detection models to realize the balance between accuracy and real-time performance. Therefore, we propose a new and lightweight object detection model. And we named it Hsd-YOLO. Firstly, HGNetv2, the backbone of the new paradigm RT-DETR for object detection, is chosen as the backbone of our model, which makes the model more lightweight and reduces the number of parameters and computation while guaranteeing the accuracy of the model’s detection. Secondly, we use the more lightweight convolutional GSConv, which is introduced into the neck to make the model balance between accuracy and speed. Finally, a unified dynamic head framework, DyHead (Dynamic Head), is introduced to make the model improve the representation of the object detection head without increasing the computational overhead. We perform comparison experiments as well as ablation experiments on a publicly available PCB defect datasets to fully illustrate the effectiveness of ours model. We conduct ablation experiments on the current state-of-the-art single-stage model YOLOv8, and our model improves AP, AR, [email protected] and [email protected] by 3.8%, 0.2%, 0.6% and 2.2%, respectively, and reduces the number of parameters in 385312 while ensuring accuracy. Comparing with major object detection models, our model performs the best in accuracy.

X-ray image detection is essential for ensuring public safety, but traditional methods rely heavily on human analysis and are relatively inefficient. To address this issue, this paper proposes a new object detection model called RFSD-YOLO, which is based on the YOLOv8 model and is specifically designed for detecting prohibited items in X-ray images. The model adopts the RFCAConv structure instead of the conventional convolutional operation. This allows for independent parameterisation among the convolutional kernels, enhancing the model's ability to capture and express potential prohibited item features. The neck section of the model includes the GSConv and VoVgscspdesigns, which aim to balance complexity and parameter size while maintaining detection performance and reducing computational burden. Additionally, we have introduced a dynamic head structure, DyHead, which replaces the traditional detection head design and improves detection accuracy without adding computational cost. The experimental results demonstrate that our enhanced model surpasses the current state-of-the-art object detection models in detecting prohibited items. Additionally, we introduce a simplified version of the RFSD-YOLOnano model to cater to resource-constrained environments. This streamlined model improves AP, AR, and mAP by 4.4%, 14.6%, and 3.4%, respectively, compared to YOLOv8n. This series of innovations not only validates the superiority of our model, but also provides new solutions in the field of automated detection of prohibited items for X-ray security screening.

In recent years, object detection models DEtection TRansformer (DETR) series based on Transformer architecture have played a huge role in various fields. However, the DETR series models are not satisfactory in small object detection. Mainly due to the huge amount of calculation of DETR, a lot of feature information will be lost in the feature fusion stage and the low tolerance of small objects to Intersection over Union (IoU). In order to solve the above problems, we propose a near real-time detection model RTS-DETR. In this paper, we revisit Real-Time DEtection TRansformer (RT-DETR), which effectively handles multi-scale features by decoupling intra-scale interaction and cross-scale fusion, but this will lose a lot of positive local information. To this end, we have improved the efficient hybrid encoder. We propose a new positional encoding method that enables the hybrid encoder to more accurately convert the input feature sequence into a high-dimensional representation, and propose a new feature fusion module to enhance the model's ability to capture local features. Furthermore, in order to improve the tolerance of small objects to IoU, we combine Normalized Wasserstein Distance (NWD) with Shape-IoU for the optimization model. This method more accurately takes into account the shape and size of objects, thereby improving detection accuracy. Our model achieves an accuracy of 38.8% (in terms of [email protected]) on the widely used VisDrone dataset, which improves the accuracy by 2.5% compared to RT-DETR with ResNet-18 as the backbone network.

Steel is an indispensable raw material in the industrial field, steel surface defects seriously affect the quality of steel, in recent years a lot of research has been carried out on the detection of steel surface defects. Existing steel defect detection methods are unable to fully mine the underlying feature information of the target image and do not achieve a dynamic balance between accuracy and speed. To address the above problems, this paper proposes an optimised target detection algorithm based on YOLOv8. First, we proposed the DMCA module, which combines the ideas of deformable convolution and multi-channel self-attention mechanism. We developed a strengthen self-attention module to enhance the process of deformable convolutional generation of offsets, so that the model can better adapt to the complex shapes of different defective targets and extract features at a deeper level. Secondly, using the idea of LKA (Large Kernel Attention), we propose the LF-MSPP lightweight module with long-range dependence and adaptive capability to capture the tele-relationships with small computational cost and parameters, improved the problem of missing defective feature information. Finally, we replaced the head of the original YOLOv8 with a Dynamic Head and used the split attention mechanism to improve the head detection capabilities while ensuring lightweight. We conduct extensive experiments on the widely used Northeastern University steel defect dataset NEU-DET. Experimental results show that the improved model improves mAP@50, mAP@50-95, AP and AR indicators by 2.4%, 2.0%, 6.1%, and 3.4% respectively compared with the original YOLOv8 model, and the number of model parameters is reduced by 11.2%. The improved model is also better than mainstream defect target detection models such as SSD, Retinanet, FasterRCNN, YOLOv5, YOLOv6, YOLOv7, YOLOv8, etc, and can better meet the accuracy and speed requirements of actual industrial production for steel surface defect detection models.

Visual Simultaneous Localization and Mapping (VSLAM) has undergone gradual development and found widespread application. However, existing VSLAM systems predominantly rely on static environment assumptions, leading to diminished robustness and localization accuracy in the presence of dynamic elements. Previous research has primarily employed geometric and semantic constraints to address dynamic regions of the scene. Nevertheless, their efficacy is limited in complex dynamic scenarios involving non-rigid objects, non-predefined motion targets, and low dynamic motion targets. Furthermore, the majority of dynamic SLAM methods are predominantly designed for indoor RGBD environments, resulting in a lack of generalizability. In this paper, a dynamic SLAM method that combines instance segmentation and optical flow called RSO-SLAM is proposed. RSO-SLAM is designed to operate effectively in diverse complex motion scenarios, both indoors and outdoors, and supports various visual sensor modes, including monocular, stereo, and RGBD setups. The proposed approach amalgamates semantic information and optical flow data by employing a “KMC:k-means$+$connectivity” based algorithm for motion region detection within the scene. Furthermore, it integrates an optical flow attenuation propagation strategy to facilitate meticulous motion probability computations and inter-frame propagation within each identified region. Our methodology’s superiority over existing dynamic SLAM approaches is firmly established through comprehensive evaluations across a diverse range of intricate dynamic scenarios. These evaluations encompass various conditions of high and low dynamism in both indoor and outdoor environments, accompanied by rigorous ablation experiments and real-world assessments. RSO-SLAM exhibits enhanced robustness and higher localization accuracy, rendering it well-suited for nearly all dynamic environments.

The PCB defect object size is small and the detection process is susceptible to background interference, usually have the problem of missed and false detection. In order to solve the above problems, an improved method based on YOLOv7 is proposed in this paper. Firstly, the bi-level routing attention (BRA) has been added to the header of the original YOLOv7 model to capture global dependencies and ensure the accuracy of small object detection and localization. Secondly, the explicit visual center (EVC) block is introduced before the fusion of mid-level features and high-level features to capture the global remote dependencies of top-level features, extract the features in local corner regions, achieve a comprehensive feature representation. Finally, the loss function is improved by changing the loss function of the original model to Wise-IoU, which allows our model to focus more on ordinary-quality anchor boxes and improve the performance of the detector while decreasing the competitiveness of anchor boxes for high-quality samples and reducing the influence of low-quality samples on the detection results. The experimental results show that the improved model improves 5% in AP and 1.9% in both AR and mAP over the original YOLOv7 model. Meanwhile, comparison experiments are conducted on the data-enhanced PCB dataset, which proves the superiority of our model over other state-of-the-art models.

The nervous system is one of the most complex biological systems, and nervous system disease (NSD) is a major cause of disability and mortality. Extensive evidence indicates that numerous dysregulated microRNAs (miRNAs) are involved in a broad spectrum of NSDs. A comprehensive review of miRNA-mediated regulatory will facilitate our understanding of miRNA dysregulation mechanisms in NSDs. In this work, we summarized currently available databases on miRNAs and NSDs, star NSD miRNAs, NSD spectrum width, miRNA spectrum width and the distribution of miRNAs in NSD sub-categories by reviewing approximately 1000 studies. In addition, we characterized miRNA-miRNA and NSD-NSD interactions from a network perspective based on miRNA-NSD benchmarking data sets. Furthermore, we summarized the regulatory principles of miRNAs in NSDs, including miRNA synergistic regulation in NSDs, miRNA modules and NSD modules. We also discussed computational challenges for identifying novel miRNAs in NSDs. Elucidating the roles of miRNAs in NSDs from a network perspective would not only improve our understanding of the precise mechanism underlying these complex diseases, but also provide novel insight into the development, diagnosis and treatment of NSDs.