Humans universally dislike the task of cleaning up a messy room. If machines were to help us with this task, they must understand human criteria for regular arrangements, such as several types of symmetry, co-linearity or co-circularity, spacing uniformity in linear or circular patterns, and further inter-object relationships that relate to style and functionality. Previous approaches for this task relied on human input to explicitly specify goal state, or synthesized scenes from scratch - but such methods do not address the rearrangement of existing messy scenes without providing a goal state. In this paper, we present LEGO-Net, a data-driven transformer-based iterative method for LEarning reGular rearrangement of Objects in messy rooms. LEGO-Net is partly inspired by diffusion models - it starts with an initial messy state and iteratively “de-noises” the position and orientation of objects to a regular state while reducing distance traveled. Given randomly perturbed object positions and orientations in an existing dataset of professionally-arranged scenes, our method is trained to recover a regular rearrangement. Results demonstrate that our method is able to reliably rearrange room scenes and outperform other methods. We additionally propose a metric for evaluating regularity in room arrangements using number-theoretic machinery.

Motivation: We introduce PRINCESS, a privacy-preserving international collaboration framework for analyzing rare disease genetic data that are distributed across different continents. PRINCESS leverages Software Guard Extensions (SGX) and hardware for trustworthy computation. Unlike a traditional international collaboration model, where individual-level patient DNA are physically centralized at a single site, PRINCESS performs a secure and distributed computation over encrypted data, fulfilling institutional policies and regulations for protected health information. Results: To demonstrate PRINCESS' performance and feasibility, we conducted a family-based allelic association study for Kawasaki Disease, with data hosted in three different continents. The experimental results show that PRINCESS provides secure and accurate analyses much faster than alternative solutions, such as homomorphic encryption and garbled circuits (over 40 000× faster). Availability and Implementation: https://github.com/achenfengb/PRINCESS_opensource. Contact: [email protected]. Supplementary information: Supplementary data are available at Bioinformatics online.