Unpaired image restoration (UIR) is a significant task due to the difficulty of acquiring paired degraded/clear images with identical backgrounds. In this paper, we propose a novel UIR method based on the assumption that an image contains both degradation-related features, which affect the level of degradation, and degradation-unrelated features, such as texture and semantic information. Our method aims to ensure that the degradation-related features of the restoration result closely resemble those of the clear image, while the degradation-unrelated features align with the input degraded image. Specifically, we introduce a Feature Orthogonalization Module optimized on Stiefel manifold to decouple image features, ensuring feature uncorrelation. A task-driven Depth-wise Feature Classifier is proposed to assign weights to uncorrelated features based on their relevance to degradation prediction. To avoid the dependence of the training process on the quality of the clear image in a single pair of input data, we propose to maintain several degradation-related proxies describing the degradation level of clear images to enhance the model's robustness. Finally, a weighted PatchNCE loss is introduced to pull degradation-related features in the output image toward those of clear images, while bringing degradation-unrelated features close to those of the degraded input.

Early smoke segmentation (ESS) enables the accurate identification of smoke sources, facilitating the prompt extinguishing of fires and preventing large-scale gas leaks. But ESS poses greater challenges than conventional object and regular smoke segmentation due to its small scale and transparent appearance, which can result in high miss detection rate and low precision. To address these issues, a Focus and Separation Network (FoSp) is proposed. We first introduce a Focus module employing bidirectional cascade which guides low-resolution and high-resolution features towards mid-resolution to locate and determine the scope of smoke, reducing the miss detection rate. Next, we propose a Separation module that separates smoke images into a pure smoke foreground and a smoke-free background, enhancing the contrast between smoke and background fundamentally, improving segmentation precision. Finally, a Domain Fusion module is developed to integrate the distinctive features of the two modules which can balance recall and precision to achieve high F_beta. Futhermore, to promote the development of ESS, we introduce a high-quality real-world dataset called SmokeSeg, which contains more small and transparent smoke than the existing datasets. Experimental results show that our model achieves the best performance on three available smoke segmentation datasets: SYN70K (mIoU: 83.00%), SMOKE5K (F_beta: 81.6%) and SmokeSeg (F_beta: 72.05%). The code can be found at https://github.com/LujianYao/FoSp.

Smoke segmentation is of great importance in precisely identifying the smoke location, enabling timely fire rescue and gas leak detection. However, due to the visual diversity and blurry edges of the non-grid smoke, noisy labels are almost inevitable in large-scale pixel-level smoke datasets. Noisy labels significantly impact the robustness of the model and may lead to serious accidents. Nevertheless, currently, there are no specific methods for addressing noisy labels in smoke segmentation. Smoke differs from regular objects as its transparency varies, causing inconsistent features in the noisy labels. In this paper, we propose a conditional sample weighting (CoSW). CoSW utilizes a multi-prototype framework, where prototypes serve as prior information to apply different weighting criteria to the different feature clusters. A novel regularized within-prototype entropy (RWE) is introduced to achieve CoSW and stable prototype update. The experiments show that our approach achieves SOTA performance on both real-world and synthetic noisy smoke segmentation datasets.

In the image dehazing task, the haze density is a key feature that affects the performance of dehazing methods. The haze density difference, which has rarely been utilized in previous methods, can guide networks to perceive different global densities and focus on local areas with high density or that are difficult to dehaze. In this paper, we propose a density-aware dehazing method named the Density Feature Refinement Network (DFR-Net), which extracts haze density features from density differences and leverages density differences to refine density features. In DFR-Net, we first generate a proposal image that has a lower overall density than the hazy input, resulting in global density differences. Additionally, the dehazing residual of the proposal image reflects the level of dehazing performance and provides local density differences that indicate localized hard dehazing or high-density areas. Subsequently, we introduce a Global Branch (GB) and a Local Branch (LB) to achieve density awareness. In GB, we use Siamese networks for feature extraction of hazy inputs and proposal images, and we propose a Global Density Feature Refinement (GDFR) module that can refine features by pushing features with different global densities further away. In LB, we explore local density features from the dehazing residuals between hazy inputs and proposal images and introduce an Intermediate Dehazing Residual Feedforward (IDRF) module to update local features and pull them close to clear image features. Sufficient experiments demonstrate that the proposed method outperforms state-of-the-art methods on various datasets.

Undoubtedly, the object is the primary factor in 3D single-object tracking (SOT) tasks. However, prior Siamese-based trackers overlook the adverse effects resulting from randomly dropped object points during backbone sampling, hindering the prediction of accurate bounding boxes (BBoxes). Therefore, developing an approach that maximizes the preservation of object points and their object-aware features is of the utmost significance. To address this, we propose an object-preserving Siamese network (OPSNet) that can effectively maintain object integrity and boost tracking performance. First, anobject highlighting moduleamplifies the object-aware features and extracts discriminative features from the template and search area. Next,object-preserving samplingselects object candidates, obtains object-preserving search area seeds, and discards background points that have less impact on tracking. Finally, anobject localization networkaccurately locates 3D BBoxes based on the object-preserving search area seeds. Extensive experiments demonstrate that the performance of OPSNet exceeds the state-of-the-art performance, achieving success gains of$\sim$9.4% and$\sim$2.5% on the KITTI and Waymo Open datasets, respectively.

Drug repositioning is an efficient and promising strategy to identify new indications for existing drugs, which can improve the productivity of traditional drug discovery and development. Rapid advances in high-throughput technologies have generated various types of biomedical data over the past decades, which lay the foundations for furthering the development of computational drug repositioning approaches. Although many researches have tried to improve the repositioning accuracy by integrating information from multiple sources and different levels, it is still appealing to further investigate how to efficiently exploit valuable data for drug repositioning. In this study, we propose an efficient approach, Random Walk on a Heterogeneous Network for Drug Repositioning (RWHNDR), to prioritize candidate drugs for diseases. First, an integrated heterogeneous network is constructed by combining multiple sources including drugs, drug targets, diseases and disease genes data. Then, a random walk model is developed to capture the global information of the heterogeneous network. RWHNDR takes advantage of drug targets and disease genes data more comprehensively for drug repositioning. The experiment results show that our approach can achieve better performance, compared with other state-of-the-art approaches which prioritized candidate drugs based on multi-source data.

Motivation: Increasing evidences have demonstrated that long noncoding RNAs (lncRNAs) play important roles in many human diseases. Therefore, predicting novel lncRNA-disease associations would contribute to dissect the complex mechanisms of disease pathogenesis. Some computational methods have been developed to infer lncRNA-disease associations. However, most of these methods infer lncRNA-disease associations only based on single data resource. Results: In this paper, we propose a new computational method to predict lncRNA-disease associations by integrating multiple biological data resources. Then, we implement this method as a web server for lncRNA-disease association prediction (LDAP). The input of the LDAP server is the lncRNA sequence. The LDAP predicts potential lncRNA-disease associations by using a bagging SVM classifier based on lncRNA similarity and disease similarity. Availability and Implementation: The web server is available at http://bioinformatics.csu.edu.cn/ldap Contact: [email protected]. Supplimentary Information: Supplementary data are available at Bioinformatics online.