We describe a synopsis structure, the Difference Digest, that allows two nodes to compute the elements belonging to the set difference in a single round with communication overhead proportional to the size of the difference times the logarithm of the keyspace. While set reconciliation can be done efficiently using logs, logs require overhead for every update and scale poorly when multiple users are to be reconciled. By contrast, our abstraction assumes no prior context and is useful in networking and distributed systems applications such as trading blocks in a peer-to-peer network, and synchronizing link-state databases after a partition.