Ultrasound (US) image despeckling is a problem of high clinical importance. Machine learning solutions to the problem are considered impractical due to the unavailability of speckle-free US image dataset. On the other hand, the classical approaches, which are able to provide the desired outputs, have limitations like input dependent parameter tuning. In this work, a convolutional neural network (CNN) is developed which learns to remove speckle from US images using the outputs of these classical approaches. It is observed that the existing approaches can be combined in a complementary manner to generate an output better than their individual outputs. Thus, the CNN is trained using the individual outputs as well as the output ensembles. It eliminates the cumbersome process of parameter tuning required by the existing approaches for every new input. Further, the proposed CNN is able to outperform the state-of-the-art despeckling approaches and produces the outputs even better than the ensembles for certain images.

Vascular region segmentation in ultrasound images is necessary for applications like automatic registration, and surgical navigation. In this paper, a pipelined network comprising of a convolutional neural network (CNN) followed by unsupervised clustering is proposed to perform vessel segmentation in liver ultrasound images. The work is motivated by the tremendous success of CNNs in object detection and localization. CNN here is trained to localize vascular regions, which are subsequently segmented by the clustering. The proposed network results in 99.14% pixel accuracy and 69.62% mean region intersection over union on 132 images. These values are better than some existing methods.

In this letter, we aim to develop a deep adversarial despeckling approach to enhance the quality of ultrasound images. Most of the existing approaches target a complete removal of speckle, which produces oversmooth outputs and results in loss of structural details. In contrast, the proposed approach reduces the speckle extent without altering the structural and qualitative attributes of the ultrasound images. A despeckling residual neural network (DRNN) is trained with an adversarial loss imposed by a discriminator. The discriminator tries to differentiate between the despeckled images generated by the DRNN and the set of high-quality images. Further to prevent the developed network from oversmoothing, a structural loss term is used along with the adversarial loss. Experimental evaluations show that the proposed DRNN outperforms the state-of-the-art despeckling approaches in terms of the structural similarity index measure, peak signal to noise ratio, edge preservation index, and speckle region's signal to noise ratio.

Anisotropic diffusion filters are one of the best choices for speckle reduction in the ultrasound images. These filters control the diffusion flux flow using local image statistics and provide the desired speckle suppression. However, inefficient use of edge characteristics results in either oversmooth image or an image containing misinterpreted spurious edges. As a result, the diagnostic quality of the images becomes a concern. To alleviate such problems, a novel anisotropic diffusion-based speckle reducing filter is proposed in this paper. A probability density function of the edges along with pixel relativity information is used to control the diffusion flux flow. The probability density function helps in removing the spurious edges and the pixel relativity reduces the oversmoothing effects. Furthermore, the filtering is performed in superpixel domain to reduce the execution time, wherein a minimum of 15% of the total number of image pixels can be used. For performance evaluation, 31 frames of three synthetic images and 40 real ultrasound images are used. In most of the experiments, the proposed filter shows a better performance as compared to the state-of-the-art filters in terms of the speckle region's signal-to-noise ratio and mean square error. It also shows a comparative performance for figure of merit and structural similarity measure index. Furthermore, in the subjective evaluation, performed by the expert radiologists, the proposed filter's outputs are preferred for the improved contrast and sharpness of the object boundaries. Hence, the proposed filtering framework is suitable to reduce the unwanted speckle and improve the quality of the ultrasound images.